Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis
Calcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in the literature. Differentiating between medullary th yroid carcinoma and an ectopic source of calcitonin secretion can represent a complex diagnostic conundrum for managing physicians, with cases of unnece...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2021-05-01
|
| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/10/4/EC-21-0071.xml |
| _version_ | 1818643512892063744 |
|---|---|
| author | David C Llewellyn Rajaventhan Srirajaskanthan Royce P Vincent Catherine Guy Eftychia E Drakou Simon J B Aylwin Ashley B Grossman John K Ramage Georgios K Dimitriadis |
| author_facet | David C Llewellyn Rajaventhan Srirajaskanthan Royce P Vincent Catherine Guy Eftychia E Drakou Simon J B Aylwin Ashley B Grossman John K Ramage Georgios K Dimitriadis |
| author_sort | David C Llewellyn |
| collection | DOAJ |
| description | Calcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in the literature. Differentiating between medullary th yroid carcinoma and an ectopic source of calcitonin secretion can represent a complex diagnostic conundrum for managing physicians, with cases of unnecessary thyroidectomy reported in the literature. This manuscript reports a case of ectopic hypercalcitonaemia from a metastatic neuroendocrine neoplasm of the lung with concurrent thyroid pathology and summarises the results of a systematic review of the literature. Medical Literature Analysis and Retrieval System Online, Excerpta Medica, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and SCOPUS databases were systematically and critically appraised for all peer reviewed manuscripts that suitably fulfilled the inclusion criteria established a priori. The protocol for this systematic review was developed according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, and followed methods outlined in The Cochrane Handbook for Systematic Reviews of Interventions. This systematic review is registered with PROSPERO. It is vital to consider diagnoses other than medullary thyroid carcinoma when presented with a patient with raised calcitonin, as it is not pathognomonic of medullary thyroid carcinoma. Lung neuroendocrine neoplasms can appear similar to medullary thyroid carcinoma histologically, they can secrete calcitonin and metastasize to the thyroid. Patients with medullary thyroid carcinoma may show stimulated calcitonin values over two or more times above the basal values, whereas calcitonin-secreting neuroendocrine neoplasms may or may not show response to stimulation tests. The present review summarises existing evidence from cases of ectopic hypercalcitonaemia to lung neuroendocrine neoplasms. |
| first_indexed | 2024-12-17T00:00:08Z |
| format | Article |
| id | doaj.art-da9e1c36fa9d493080d323a4289131d7 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-17T00:00:08Z |
| publishDate | 2021-05-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-da9e1c36fa9d493080d323a4289131d72022-12-21T22:11:06ZengBioscientificaEndocrine Connections2049-36142049-36142021-05-01104447461https://doi.org/10.1530/EC-21-0071Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesisDavid C Llewellyn0Rajaventhan Srirajaskanthan1Royce P Vincent2Catherine Guy3Eftychia E Drakou4Simon J B Aylwin5Ashley B Grossman6John K Ramage7Georgios K Dimitriadis8Department of Endocrinology ASO/EASO COM, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UKNeuroendocrine Tumour Unit, Kings Health Partners ENETS Centre of Excellence, Denmark Hill, London, UK; Faculty of Life Sciences and Medicine, Kings College London, London, UK Faculty of Life Sciences and Medicine, Kings College London, London, UK; Department of Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UKDepartment of Cellular Pathology, Royal Sussex County Hospital, Eastern Road, Brighton, UKDepartment of Clinical Oncology, Guy’s Cancer Centre – Guy’s and St Thomas’ NHS Foundation Trust, Great Maze Pond, London, UKDepartment of Endocrinology ASO/EASO COM, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK; Neuroendocrine Tumour Unit, Kings Health Partners ENETS Centre of Excellence, Denmark Hill, London, UKOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK; Barts and the London School of Medicine, Centre for Endocrinology, William Harvey Institute, London, UK; Neuroendocrine Tumour Unit, Royal Free Hospital, London, UKNeuroendocrine Tumour Unit, Kings Health Partners ENETS Centre of Excellence, Denmark Hill, London, UK; Faculty of Life Sciences and Medicine, Kings College London, London, UKDepartment of Endocrinology ASO/EASO COM, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK; Faculty of Life Sciences and Medicine, School of Life Course Sciences, Obesity Immunometabolism and Diabetes Group, King’s College London, London, UKCalcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in the literature. Differentiating between medullary th yroid carcinoma and an ectopic source of calcitonin secretion can represent a complex diagnostic conundrum for managing physicians, with cases of unnecessary thyroidectomy reported in the literature. This manuscript reports a case of ectopic hypercalcitonaemia from a metastatic neuroendocrine neoplasm of the lung with concurrent thyroid pathology and summarises the results of a systematic review of the literature. Medical Literature Analysis and Retrieval System Online, Excerpta Medica, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and SCOPUS databases were systematically and critically appraised for all peer reviewed manuscripts that suitably fulfilled the inclusion criteria established a priori. The protocol for this systematic review was developed according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, and followed methods outlined in The Cochrane Handbook for Systematic Reviews of Interventions. This systematic review is registered with PROSPERO. It is vital to consider diagnoses other than medullary thyroid carcinoma when presented with a patient with raised calcitonin, as it is not pathognomonic of medullary thyroid carcinoma. Lung neuroendocrine neoplasms can appear similar to medullary thyroid carcinoma histologically, they can secrete calcitonin and metastasize to the thyroid. Patients with medullary thyroid carcinoma may show stimulated calcitonin values over two or more times above the basal values, whereas calcitonin-secreting neuroendocrine neoplasms may or may not show response to stimulation tests. The present review summarises existing evidence from cases of ectopic hypercalcitonaemia to lung neuroendocrine neoplasms.https://ec.bioscientifica.com/view/journals/ec/10/4/EC-21-0071.xmlcalcitoninectopicparaneoplasticneuroendocrine neoplasmlungsystematic review |
| spellingShingle | David C Llewellyn Rajaventhan Srirajaskanthan Royce P Vincent Catherine Guy Eftychia E Drakou Simon J B Aylwin Ashley B Grossman John K Ramage Georgios K Dimitriadis Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis Endocrine Connections calcitonin ectopic paraneoplastic neuroendocrine neoplasm lung systematic review |
| title | Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis |
| title_full | Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis |
| title_fullStr | Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis |
| title_full_unstemmed | Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis |
| title_short | Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis |
| title_sort | calcitonin secreting neuroendocrine neoplasms of the lung a systematic review and narrative synthesis |
| topic | calcitonin ectopic paraneoplastic neuroendocrine neoplasm lung systematic review |
| url | https://ec.bioscientifica.com/view/journals/ec/10/4/EC-21-0071.xml |
| work_keys_str_mv | AT davidcllewellyn calcitoninsecretingneuroendocrineneoplasmsofthelungasystematicreviewandnarrativesynthesis AT rajaventhansrirajaskanthan calcitoninsecretingneuroendocrineneoplasmsofthelungasystematicreviewandnarrativesynthesis AT roycepvincent calcitoninsecretingneuroendocrineneoplasmsofthelungasystematicreviewandnarrativesynthesis AT catherineguy calcitoninsecretingneuroendocrineneoplasmsofthelungasystematicreviewandnarrativesynthesis AT eftychiaedrakou calcitoninsecretingneuroendocrineneoplasmsofthelungasystematicreviewandnarrativesynthesis AT simonjbaylwin calcitoninsecretingneuroendocrineneoplasmsofthelungasystematicreviewandnarrativesynthesis AT ashleybgrossman calcitoninsecretingneuroendocrineneoplasmsofthelungasystematicreviewandnarrativesynthesis AT johnkramage calcitoninsecretingneuroendocrineneoplasmsofthelungasystematicreviewandnarrativesynthesis AT georgioskdimitriadis calcitoninsecretingneuroendocrineneoplasmsofthelungasystematicreviewandnarrativesynthesis |