Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019
Influenza B viruses (IBV) are an important cause of morbidity and mortality during interpandemic periods in the human population. Two phylogenetically distinct IBV lineages, B/Yamagata and B/Victoria, co-circulate worldwide and they present challenges for vaccine strain selection. Until the present...
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MDPI AG
2020-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/4/591 |
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| author | María José Rivas Miguel Alegretti Leticia Cóppola Viviana Ramas Héctor Chiparelli Natalia Goñi |
| author_facet | María José Rivas Miguel Alegretti Leticia Cóppola Viviana Ramas Héctor Chiparelli Natalia Goñi |
| author_sort | María José Rivas |
| collection | DOAJ |
| description | Influenza B viruses (IBV) are an important cause of morbidity and mortality during interpandemic periods in the human population. Two phylogenetically distinct IBV lineages, B/Yamagata and B/Victoria, co-circulate worldwide and they present challenges for vaccine strain selection. Until the present study, there was little information regarding the pattern of the circulating strains of IBV in Uruguay. A subset of positive influenza B samples from influenza-like illness (ILI) outpatients and severe acute respiratory illness (SARI) inpatients detected in sentinel hospitals in Uruguay during 2012–2019 were selected. The sequencing of the hemagglutinin (HA) and neuraminidase (NA) genes showed substitutions at the amino acid level. Phylogenetic analysis reveals the co-circulation of both lineages in almost all seasonal epidemics in Uruguay, and allows recognizing a lineage-level vaccine mismatch in approximately one-third of the seasons studied. The epidemiological results show that the proportion of IBV found in ILI was significantly higher than the observed in SARI cases across different groups of age (9.7% ILI, 3.2% SARI) and patients between 5–14 years constituted the majority (33%) of all influenza B infection (<i>p</i> < 0.05). Interestingly, we found that individuals >25 years were particularly vulnerable to Yamagata lineage infections. |
| first_indexed | 2024-03-10T20:22:41Z |
| format | Article |
| id | doaj.art-da9f81f632404e3ca1330794c41207d7 |
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| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T20:22:41Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-da9f81f632404e3ca1330794c41207d72023-11-19T22:06:37ZengMDPI AGMicroorganisms2076-26072020-04-018459110.3390/microorganisms8040591Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019María José Rivas0Miguel Alegretti1Leticia Cóppola2Viviana Ramas3Héctor Chiparelli4Natalia Goñi5Centro Nacional de Referencia de Influenza, Unidad de Virología, Departamento de Laboratorios de Salud Pública, Ministerio de Salud, Montevideo 11600, UruguayDepartamento de Vigilancia en Salud, Ministerio de Salud, Montevideo 11200, UruguayCentro Nacional de Referencia de Influenza, Unidad de Virología, Departamento de Laboratorios de Salud Pública, Ministerio de Salud, Montevideo 11600, UruguayCentro Nacional de Referencia de Influenza, Unidad de Virología, Departamento de Laboratorios de Salud Pública, Ministerio de Salud, Montevideo 11600, UruguayCentro Nacional de Referencia de Influenza, Unidad de Virología, Departamento de Laboratorios de Salud Pública, Ministerio de Salud, Montevideo 11600, UruguayCentro Nacional de Referencia de Influenza, Unidad de Virología, Departamento de Laboratorios de Salud Pública, Ministerio de Salud, Montevideo 11600, UruguayInfluenza B viruses (IBV) are an important cause of morbidity and mortality during interpandemic periods in the human population. Two phylogenetically distinct IBV lineages, B/Yamagata and B/Victoria, co-circulate worldwide and they present challenges for vaccine strain selection. Until the present study, there was little information regarding the pattern of the circulating strains of IBV in Uruguay. A subset of positive influenza B samples from influenza-like illness (ILI) outpatients and severe acute respiratory illness (SARI) inpatients detected in sentinel hospitals in Uruguay during 2012–2019 were selected. The sequencing of the hemagglutinin (HA) and neuraminidase (NA) genes showed substitutions at the amino acid level. Phylogenetic analysis reveals the co-circulation of both lineages in almost all seasonal epidemics in Uruguay, and allows recognizing a lineage-level vaccine mismatch in approximately one-third of the seasons studied. The epidemiological results show that the proportion of IBV found in ILI was significantly higher than the observed in SARI cases across different groups of age (9.7% ILI, 3.2% SARI) and patients between 5–14 years constituted the majority (33%) of all influenza B infection (<i>p</i> < 0.05). Interestingly, we found that individuals >25 years were particularly vulnerable to Yamagata lineage infections.https://www.mdpi.com/2076-2607/8/4/591influenza Bphylogeneticepidemiologysurveillancevictoriayamagata |
| spellingShingle | María José Rivas Miguel Alegretti Leticia Cóppola Viviana Ramas Héctor Chiparelli Natalia Goñi Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019 Microorganisms influenza B phylogenetic epidemiology surveillance victoria yamagata |
| title | Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019 |
| title_full | Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019 |
| title_fullStr | Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019 |
| title_full_unstemmed | Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019 |
| title_short | Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012–2019 |
| title_sort | epidemiology and genetic variability of circulating influenza b viruses in uruguay 2012 2019 |
| topic | influenza B phylogenetic epidemiology surveillance victoria yamagata |
| url | https://www.mdpi.com/2076-2607/8/4/591 |
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