FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones

FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones

Abstract An efficient hydrazine substitution of p‐nitro‐aryl fluorides with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. This hydrazine substitutions of p‐nitro‐aryl fluorides bearing electron‐withdrawing groups proceeded efficiently with high yield and selectivity. Similarl...

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Bibliographic Details
Main Authors: Dingzhong Li, Wensheng Zhang, Dr. Longzhi Zhu, Prof. Dr. Shuang‐Feng Yin, Prof. Dr. Nobuaki Kambe, Prof. Dr. Renhua Qiu
Format: Article
Language:English
Published: Wiley-VCH 2022-05-01
Series:ChemistryOpen
Subjects:
hydrazine substitution
FeO(OH)@C nanoparticles
industrial C. lanceolata carbon
phthalazinones
p-nitro-aromatic fluorides
Online Access:https://doi.org/10.1002/open.202200023
Description
Summary:Abstract An efficient hydrazine substitution of p‐nitro‐aryl fluorides with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. This hydrazine substitutions of p‐nitro‐aryl fluorides bearing electron‐withdrawing groups proceeded efficiently with high yield and selectivity. Similarly, hydrogenations of p‐nitro‐aryl fluorides containing electron‐donating groups also smoothly proceeded under mild conditions. Furthermore, with these prepared aryl hydrazines, some phthalazinones, interesting as potential structures for pharmaceuticals, have successfully been synthesized in high yields.
ISSN:2191-1363

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