FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones
Abstract An efficient hydrazine substitution of p‐nitro‐aryl fluorides with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. This hydrazine substitutions of p‐nitro‐aryl fluorides bearing electron‐withdrawing groups proceeded efficiently with high yield and selectivity. Similarl...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2022-05-01
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| Series: | ChemistryOpen |
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| Online Access: | https://doi.org/10.1002/open.202200023 |
| _version_ | 1811247398212599808 |
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| author | Dingzhong Li Wensheng Zhang Dr. Longzhi Zhu Prof. Dr. Shuang‐Feng Yin Prof. Dr. Nobuaki Kambe Prof. Dr. Renhua Qiu |
| author_facet | Dingzhong Li Wensheng Zhang Dr. Longzhi Zhu Prof. Dr. Shuang‐Feng Yin Prof. Dr. Nobuaki Kambe Prof. Dr. Renhua Qiu |
| author_sort | Dingzhong Li |
| collection | DOAJ |
| description | Abstract An efficient hydrazine substitution of p‐nitro‐aryl fluorides with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. This hydrazine substitutions of p‐nitro‐aryl fluorides bearing electron‐withdrawing groups proceeded efficiently with high yield and selectivity. Similarly, hydrogenations of p‐nitro‐aryl fluorides containing electron‐donating groups also smoothly proceeded under mild conditions. Furthermore, with these prepared aryl hydrazines, some phthalazinones, interesting as potential structures for pharmaceuticals, have successfully been synthesized in high yields. |
| first_indexed | 2024-04-12T15:08:10Z |
| format | Article |
| id | doaj.art-da9fa761793c461c9a6ad7f0578485a3 |
| institution | Directory Open Access Journal |
| issn | 2191-1363 |
| language | English |
| last_indexed | 2024-04-12T15:08:10Z |
| publishDate | 2022-05-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | ChemistryOpen |
| spelling | doaj.art-da9fa761793c461c9a6ad7f0578485a32022-12-22T03:27:52ZengWiley-VCHChemistryOpen2191-13632022-05-01115n/an/a10.1002/open.202200023FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of PhthalazinonesDingzhong Li0Wensheng Zhang1Dr. Longzhi Zhu2Prof. Dr. Shuang‐Feng Yin3Prof. Dr. Nobuaki Kambe4Prof. Dr. Renhua Qiu5State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. ChinaState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. ChinaCenter for Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Lab of Optoelectronics Devices and systems of Ministry of Education/Guangdong Province Shenzhen University Shenzhen 518060 P. R. ChinaState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. ChinaState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. ChinaState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. ChinaAbstract An efficient hydrazine substitution of p‐nitro‐aryl fluorides with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. This hydrazine substitutions of p‐nitro‐aryl fluorides bearing electron‐withdrawing groups proceeded efficiently with high yield and selectivity. Similarly, hydrogenations of p‐nitro‐aryl fluorides containing electron‐donating groups also smoothly proceeded under mild conditions. Furthermore, with these prepared aryl hydrazines, some phthalazinones, interesting as potential structures for pharmaceuticals, have successfully been synthesized in high yields.https://doi.org/10.1002/open.202200023hydrazine substitutionFeO(OH)@C nanoparticlesindustrial C. lanceolata carbonphthalazinonesp-nitro-aromatic fluorides |
| spellingShingle | Dingzhong Li Wensheng Zhang Dr. Longzhi Zhu Prof. Dr. Shuang‐Feng Yin Prof. Dr. Nobuaki Kambe Prof. Dr. Renhua Qiu FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones ChemistryOpen hydrazine substitution FeO(OH)@C nanoparticles industrial C. lanceolata carbon phthalazinones p-nitro-aromatic fluorides |
| title | FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones |
| title_full | FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones |
| title_fullStr | FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones |
| title_full_unstemmed | FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones |
| title_short | FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones |
| title_sort | feo oh c catalyzed selective hydrazine substitution of p nitro aryl fluorides and their application for the synthesis of phthalazinones |
| topic | hydrazine substitution FeO(OH)@C nanoparticles industrial C. lanceolata carbon phthalazinones p-nitro-aromatic fluorides |
| url | https://doi.org/10.1002/open.202200023 |
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