Biomarkers of Oxidative stress in essential hypertension
Introduction There is a increasing amount of verification supporting the view that oxidative stress is involved and plays a important role in the pathophysiology of primary hypertension. Objective: This research examines the association of blood pressure with blood oxidative stress-related par...
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| Format: | Article |
| Language: | English |
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Prathima Institute of Medical Sciences
2018-12-01
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| Series: | Perspectives In Medical Research |
| Subjects: | |
| Online Access: | http://www.pimr.org.in/shah-vol-6-issue-3-2018.PDF |
| _version_ | 1797462414387576832 |
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| author | Navid N Shah1, Srinivas Ch2 |
| author_facet | Navid N Shah1, Srinivas Ch2 |
| author_sort | Navid N Shah1, Srinivas Ch2 |
| collection | DOAJ |
| description | Introduction
There is a increasing amount of verification supporting
the view that oxidative stress is involved and plays a important
role in the pathophysiology of primary hypertension.
Objective:
This research examines the association of blood
pressure with blood oxidative stress-related parameters in
normotensive and hypertensive subjects.
Materials & Methods:
A cross-sectional design was applied to 32 hypertensive
patients and 33 healthy normotensive subjects. All subjects
were men between the ages of 35 and 60 years. Cases of
dyslipidemia, diabetes mellitus, obesity, smoking and those
taking medication were excluded from the study. In
erythrocyte lipid peroxidation (malondialdehyde) and reduced/
oxidized glutathione ratio (GSH/GSSG) were determined.
Parameters measured in the plasma of test subjects were
plasma antioxidant status, plasma vitamin C, vitamin E, lipid
peroxidation (8-isoprostane), blood pressure modulators
renin, aldosterone, endothelin-1, and homocysteine.
Results: Daytime systolic and diastolic blood pressures
of hypertensives were negatively correlated with plasma
antioxidant capacity (r=–0.54, p=0.001 and r=–0.60, p<0.001),
plasma vitamin C levels (r=–0.47, p=0.006 and r=–0.43, p=0.01),
erythrocyte activity of antioxidant enzymes, and erythrocyte
GSH/GSSG ratio, with hypertensives showing higher levels of
oxidative stress.
Conclusion: Blood pressures showed a positive
correlation with both plasma and urine 8-isoprostane. These
results show a strong association between blood pressure and
some oxidative stress-related parameters and propose a
probable role of oxidative stress in the pathophysiology of
essential hypertension |
| first_indexed | 2024-03-09T17:36:10Z |
| format | Article |
| id | doaj.art-daa06906cd0a4d9db5644c6e24ae5b11 |
| institution | Directory Open Access Journal |
| issn | 2348-1447 2348-229X |
| language | English |
| last_indexed | 2024-03-09T17:36:10Z |
| publishDate | 2018-12-01 |
| publisher | Prathima Institute of Medical Sciences |
| record_format | Article |
| series | Perspectives In Medical Research |
| spelling | doaj.art-daa06906cd0a4d9db5644c6e24ae5b112023-11-24T11:52:43ZengPrathima Institute of Medical SciencesPerspectives In Medical Research2348-14472348-229X2018-12-01631823Biomarkers of Oxidative stress in essential hypertensionNavid N Shah1, Srinivas Ch20 Prathima Insitute of Medical SciencesIntroduction There is a increasing amount of verification supporting the view that oxidative stress is involved and plays a important role in the pathophysiology of primary hypertension. Objective: This research examines the association of blood pressure with blood oxidative stress-related parameters in normotensive and hypertensive subjects. Materials & Methods: A cross-sectional design was applied to 32 hypertensive patients and 33 healthy normotensive subjects. All subjects were men between the ages of 35 and 60 years. Cases of dyslipidemia, diabetes mellitus, obesity, smoking and those taking medication were excluded from the study. In erythrocyte lipid peroxidation (malondialdehyde) and reduced/ oxidized glutathione ratio (GSH/GSSG) were determined. Parameters measured in the plasma of test subjects were plasma antioxidant status, plasma vitamin C, vitamin E, lipid peroxidation (8-isoprostane), blood pressure modulators renin, aldosterone, endothelin-1, and homocysteine. Results: Daytime systolic and diastolic blood pressures of hypertensives were negatively correlated with plasma antioxidant capacity (r=–0.54, p=0.001 and r=–0.60, p<0.001), plasma vitamin C levels (r=–0.47, p=0.006 and r=–0.43, p=0.01), erythrocyte activity of antioxidant enzymes, and erythrocyte GSH/GSSG ratio, with hypertensives showing higher levels of oxidative stress. Conclusion: Blood pressures showed a positive correlation with both plasma and urine 8-isoprostane. These results show a strong association between blood pressure and some oxidative stress-related parameters and propose a probable role of oxidative stress in the pathophysiology of essential hypertensionhttp://www.pimr.org.in/shah-vol-6-issue-3-2018.PDFantioxidantsessential hypertension8- isoprostaneoxidative stressvitamin c |
| spellingShingle | Navid N Shah1, Srinivas Ch2 Biomarkers of Oxidative stress in essential hypertension Perspectives In Medical Research antioxidants essential hypertension 8- isoprostane oxidative stress vitamin c |
| title | Biomarkers of Oxidative stress in essential hypertension |
| title_full | Biomarkers of Oxidative stress in essential hypertension |
| title_fullStr | Biomarkers of Oxidative stress in essential hypertension |
| title_full_unstemmed | Biomarkers of Oxidative stress in essential hypertension |
| title_short | Biomarkers of Oxidative stress in essential hypertension |
| title_sort | biomarkers of oxidative stress in essential hypertension |
| topic | antioxidants essential hypertension 8- isoprostane oxidative stress vitamin c |
| url | http://www.pimr.org.in/shah-vol-6-issue-3-2018.PDF |
| work_keys_str_mv | AT navidnshah1srinivasch2 biomarkersofoxidativestressinessentialhypertension |