Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers
Coke oven emissions (COEs) contain many carcinogenic polycyclic aromatic hydrocarbons (PAHs). Telomere damage is an early biological marker reflecting long-term COEs-exposure. Whereas, whether the genetic variations of telomere-regulated gene TNKS have an effect on the COEs-induced telomere damage i...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132201329X |
| _version_ | 1828064093146185728 |
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| author | Xiaoran Duan Tao Huang Daping Zhang Yujie Wei Lifeng Li Wu Yao Liuxin Cui Xiaoshan Zhou Yongli Yang Wei Wang Jie Zhao |
| author_facet | Xiaoran Duan Tao Huang Daping Zhang Yujie Wei Lifeng Li Wu Yao Liuxin Cui Xiaoshan Zhou Yongli Yang Wei Wang Jie Zhao |
| author_sort | Xiaoran Duan |
| collection | DOAJ |
| description | Coke oven emissions (COEs) contain many carcinogenic polycyclic aromatic hydrocarbons (PAHs). Telomere damage is an early biological marker reflecting long-term COEs-exposure. Whereas, whether the genetic variations of telomere-regulated gene TNKS have an effect on the COEs-induced telomere damage is unknown. So we detected the environmental exposure levels, relative telomere length (RTL), and TNKS genetic polymorphisms among 544 COEs-exposure workers and 238 healthy participants. We found that the RTL of the wild homozygous GG genotype in rs1055328 locus was statistically shorter compared with the CG+CC genotype for the healthy participants using covariance analysis(P = 0.008). In the Generalized linear model (GLM) analysis, TNKS rs1055328 GG could accelerate telomere shortening (P = 0.011); and the interaction between TNKS rs1055328 GG and COEs-exposure had an effect on RTL (P = 0.002). In conclusion, this study was the first to discover the role of TNKS rs1055328 locus in COEs-induced telomere damage, and proved that chromosomal damage was a combined consequence of environmental and genetic factors. |
| first_indexed | 2024-04-10T22:53:04Z |
| format | Article |
| id | doaj.art-daa0763aa705408f8b12493bbc01712a |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-10T22:53:04Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-daa0763aa705408f8b12493bbc01712a2023-01-15T04:21:00ZengElsevierEcotoxicology and Environmental Safety0147-65132023-01-01250114489Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workersXiaoran Duan0Tao Huang1Daping Zhang2Yujie Wei3Lifeng Li4Wu Yao5Liuxin Cui6Xiaoshan Zhou7Yongli Yang8Wei Wang9Jie Zhao10National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, Henan, China; Medical School, Huanghe Science and Technology University, Zhengzhou, Henan, China; Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaMedical School, Huanghe Science and Technology University, Zhengzhou, Henan, ChinaDepartment of Cardiology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan, ChinaNational Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, Henan, ChinaNational Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, Henan, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaDepartment of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China; Correspondence to: Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, No.100Kexue Road, Zhengzhou, 450001, China. Fax: 86-371-67781466.National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, Henan, China; Correspondence to: The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Road, Erqi District, Zhengzhou, 450052, China. Fax: 86-371-67966215.Coke oven emissions (COEs) contain many carcinogenic polycyclic aromatic hydrocarbons (PAHs). Telomere damage is an early biological marker reflecting long-term COEs-exposure. Whereas, whether the genetic variations of telomere-regulated gene TNKS have an effect on the COEs-induced telomere damage is unknown. So we detected the environmental exposure levels, relative telomere length (RTL), and TNKS genetic polymorphisms among 544 COEs-exposure workers and 238 healthy participants. We found that the RTL of the wild homozygous GG genotype in rs1055328 locus was statistically shorter compared with the CG+CC genotype for the healthy participants using covariance analysis(P = 0.008). In the Generalized linear model (GLM) analysis, TNKS rs1055328 GG could accelerate telomere shortening (P = 0.011); and the interaction between TNKS rs1055328 GG and COEs-exposure had an effect on RTL (P = 0.002). In conclusion, this study was the first to discover the role of TNKS rs1055328 locus in COEs-induced telomere damage, and proved that chromosomal damage was a combined consequence of environmental and genetic factors.http://www.sciencedirect.com/science/article/pii/S014765132201329XCoke Oven EmissionsTNKS geneTelomere Damage |
| spellingShingle | Xiaoran Duan Tao Huang Daping Zhang Yujie Wei Lifeng Li Wu Yao Liuxin Cui Xiaoshan Zhou Yongli Yang Wei Wang Jie Zhao Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers Ecotoxicology and Environmental Safety Coke Oven Emissions TNKS gene Telomere Damage |
| title | Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers |
| title_full | Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers |
| title_fullStr | Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers |
| title_full_unstemmed | Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers |
| title_short | Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers |
| title_sort | effect and interaction of tnks genetic polymorphisms and environmental factors on telomere damage in coes exposure workers |
| topic | Coke Oven Emissions TNKS gene Telomere Damage |
| url | http://www.sciencedirect.com/science/article/pii/S014765132201329X |
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