Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseases
Messenger RNA (mRNA) vaccines have been studied for decades, but only recently, during the COVID-19 pandemic, has the technology garnered noteworthy attention. In contrast to traditional vaccines, mRNA vaccines elicit a more balanced immune response, triggering both humoral and cellular components o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | RNA Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15476286.2022.2055923 |
| _version_ | 1797404001587691520 |
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| author | Nusrat Zahan Rouf Sumit Biswas Nawseen Tarannum Labiba Mustabina Oishee Mutia Masuka Muna |
| author_facet | Nusrat Zahan Rouf Sumit Biswas Nawseen Tarannum Labiba Mustabina Oishee Mutia Masuka Muna |
| author_sort | Nusrat Zahan Rouf |
| collection | DOAJ |
| description | Messenger RNA (mRNA) vaccines have been studied for decades, but only recently, during the COVID-19 pandemic, has the technology garnered noteworthy attention. In contrast to traditional vaccines, mRNA vaccines elicit a more balanced immune response, triggering both humoral and cellular components of the adaptive immune system. However, some inherent hurdles associated with stability, immunogenicity, in vivo delivery, along with the novelty of the technology, have generated scepticism in the adoption of mRNA vaccines. Recent developments have pushed to bypass these issues and the approval of mRNA-based vaccines to combat COVID-19 has further highlighted the feasibility, safety, efficacy, and rapid development potential of this platform, thereby pushing it to the forefront of emerging therapeutics. This review aims to demystify mRNA vaccines, delineating the evolution of the technology which has emerged as a timely solution to COVID-19 and exploring the immense potential it offers as a prophylactic option for other cryptic diseases. |
| first_indexed | 2024-03-09T02:46:48Z |
| format | Article |
| id | doaj.art-daa07640dbe34aff90ae401d93add09d |
| institution | Directory Open Access Journal |
| issn | 1547-6286 1555-8584 |
| language | English |
| last_indexed | 2024-03-09T02:46:48Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj.art-daa07640dbe34aff90ae401d93add09d2023-12-05T16:09:51ZengTaylor & Francis GroupRNA Biology1547-62861555-85842022-12-0119138641010.1080/15476286.2022.20559232055923Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseasesNusrat Zahan Rouf0Sumit Biswas1Nawseen Tarannum2Labiba Mustabina Oishee3Mutia Masuka Muna4Medicine, & Health, University of ManchesterInstitute of Physiology and Pathophysiology, University of MarburgMedicine, & Health, University of ManchesterUniversity of Nottingham, Sutton Bonington CampusUniversity at BuffaloMessenger RNA (mRNA) vaccines have been studied for decades, but only recently, during the COVID-19 pandemic, has the technology garnered noteworthy attention. In contrast to traditional vaccines, mRNA vaccines elicit a more balanced immune response, triggering both humoral and cellular components of the adaptive immune system. However, some inherent hurdles associated with stability, immunogenicity, in vivo delivery, along with the novelty of the technology, have generated scepticism in the adoption of mRNA vaccines. Recent developments have pushed to bypass these issues and the approval of mRNA-based vaccines to combat COVID-19 has further highlighted the feasibility, safety, efficacy, and rapid development potential of this platform, thereby pushing it to the forefront of emerging therapeutics. This review aims to demystify mRNA vaccines, delineating the evolution of the technology which has emerged as a timely solution to COVID-19 and exploring the immense potential it offers as a prophylactic option for other cryptic diseases.http://dx.doi.org/10.1080/15476286.2022.2055923mrna vaccineivt-mrnanucleoside modified mrnain vivo delivery of mrnavaccine efficacyvaccine storagecovid-19mrna vaccine for infectious disease |
| spellingShingle | Nusrat Zahan Rouf Sumit Biswas Nawseen Tarannum Labiba Mustabina Oishee Mutia Masuka Muna Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseases RNA Biology mrna vaccine ivt-mrna nucleoside modified mrna in vivo delivery of mrna vaccine efficacy vaccine storage covid-19 mrna vaccine for infectious disease |
| title | Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseases |
| title_full | Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseases |
| title_fullStr | Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseases |
| title_full_unstemmed | Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseases |
| title_short | Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseases |
| title_sort | demystifying mrna vaccines an emerging platform at the forefront of cryptic diseases |
| topic | mrna vaccine ivt-mrna nucleoside modified mrna in vivo delivery of mrna vaccine efficacy vaccine storage covid-19 mrna vaccine for infectious disease |
| url | http://dx.doi.org/10.1080/15476286.2022.2055923 |
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