Systematic use of long-acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer: A pilot study
ObjectiveThe need of luteal support after FET is no longer to be proven. Different routes of progesterone administration are available with interindividual differences in metabolization and serum progesterone levels, the latter being highly correlated with pregnancy and delivery rates. The administr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1039579/full |
| _version_ | 1797978590476763136 |
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| author | Virginie Simon Virginie Simon Geoffroy Robin Geoffroy Robin Laura Keller Camille Ternynck Camille Ternynck Sophie Jonard Sophie Jonard Camille Robin Christine Decanter Pauline Plouvier |
| author_facet | Virginie Simon Virginie Simon Geoffroy Robin Geoffroy Robin Laura Keller Camille Ternynck Camille Ternynck Sophie Jonard Sophie Jonard Camille Robin Christine Decanter Pauline Plouvier |
| author_sort | Virginie Simon |
| collection | DOAJ |
| description | ObjectiveThe need of luteal support after FET is no longer to be proven. Different routes of progesterone administration are available with interindividual differences in metabolization and serum progesterone levels, the latter being highly correlated with pregnancy and delivery rates. The administration of 2 different routes of progestogen significantly improves success rates in FET. The aim of the current study was to investigate the added value to combine intramuscular administration of progesterone to dydrogesterone in fresh embryo transfer.MethodsThis is a retrospective study from prospectively collected data. Patient, aged between 18 and 43 years old, had received a fresh blastocyst transfer between January 2021 and June 2021. In the first group, all patients received only oral dydrogesterone 10mg, three times a day, beginning the evening of oocyte retrieval. In the second group, patients received, in addition to dydrogesterone, a weekly intramuscular injection of progesterone started the day of embryo transfer. Primary endpoint was ongoing pregnancy rate.Results171 fresh single blastocyst transfers have been performed during this period. 82 patients were included in “dydrogesterone only” and 89 patients in “dydrogesterone + IM”. Our two groups were comparable except for body mass index. After adjustment on BMI, our two groups were comparable regarding implantation rate, early pregnancy rate (46.1 versus 54.9, OR 1.44 [0.78; 2.67], p=0.25) miscarriage rate, ongoing pregnancy rate (30.3 versus 43.9, OR 1.85 [0.97; 3.53] p= 0.06).ConclusionUsing systematically long acting intramuscular progesterone injection in addition to oral dydrogesterone as luteal phase support seems to have no significant impact on IVF outcomes when a single fresh blastocyst transfer is performed. |
| first_indexed | 2024-04-11T05:25:24Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T05:25:24Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-daa1283ba93a4363bea3da9da5ae988e2022-12-23T08:32:56ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10395791039579Systematic use of long-acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer: A pilot studyVirginie Simon0Virginie Simon1Geoffroy Robin2Geoffroy Robin3Laura Keller4Camille Ternynck5Camille Ternynck6Sophie Jonard7Sophie Jonard8Camille Robin9Christine Decanter10Pauline Plouvier11Department of Assisted Reproductive Technologies and Fertility Preservation, Jeanne de Flandre Hospital, Lille, FranceUniv. Lille, Faculty of Medicine, Lille, FranceDepartment of Assisted Reproductive Technologies and Fertility Preservation, Jeanne de Flandre Hospital, Lille, FranceUniv. Lille, Faculty of Medicine, Lille, FranceInstitut de Biologie de la Reproduction-Spermiologie-Centre d'étude et de Conservation des Oeufs et du Sperme Humain (CECOS), Hôpital Jeanne de Flandre, Centre Hospitalier Universitaire de Lille, Lille, FranceUniv. Lille, University Hospital Center (CHU) Lille, Research Unity (ULR) 2694-METRICS: Evaluation des Technologies de Santé et des Pratiques médicales, Lille, FranceUniversity Hospital Center (CHU) Lille, Department of Biostatistics, Lille, FranceDepartment of Assisted Reproductive Technologies and Fertility Preservation, Jeanne de Flandre Hospital, Lille, FranceUniv. Lille, Faculty of Medicine, Lille, FranceDepartment of Assisted Reproductive Technologies and Fertility Preservation, Jeanne de Flandre Hospital, Lille, FranceDepartment of Assisted Reproductive Technologies and Fertility Preservation, Jeanne de Flandre Hospital, Lille, FranceDepartment of Assisted Reproductive Technologies and Fertility Preservation, Jeanne de Flandre Hospital, Lille, FranceObjectiveThe need of luteal support after FET is no longer to be proven. Different routes of progesterone administration are available with interindividual differences in metabolization and serum progesterone levels, the latter being highly correlated with pregnancy and delivery rates. The administration of 2 different routes of progestogen significantly improves success rates in FET. The aim of the current study was to investigate the added value to combine intramuscular administration of progesterone to dydrogesterone in fresh embryo transfer.MethodsThis is a retrospective study from prospectively collected data. Patient, aged between 18 and 43 years old, had received a fresh blastocyst transfer between January 2021 and June 2021. In the first group, all patients received only oral dydrogesterone 10mg, three times a day, beginning the evening of oocyte retrieval. In the second group, patients received, in addition to dydrogesterone, a weekly intramuscular injection of progesterone started the day of embryo transfer. Primary endpoint was ongoing pregnancy rate.Results171 fresh single blastocyst transfers have been performed during this period. 82 patients were included in “dydrogesterone only” and 89 patients in “dydrogesterone + IM”. Our two groups were comparable except for body mass index. After adjustment on BMI, our two groups were comparable regarding implantation rate, early pregnancy rate (46.1 versus 54.9, OR 1.44 [0.78; 2.67], p=0.25) miscarriage rate, ongoing pregnancy rate (30.3 versus 43.9, OR 1.85 [0.97; 3.53] p= 0.06).ConclusionUsing systematically long acting intramuscular progesterone injection in addition to oral dydrogesterone as luteal phase support seems to have no significant impact on IVF outcomes when a single fresh blastocyst transfer is performed.https://www.frontiersin.org/articles/10.3389/fendo.2022.1039579/fullluteal phase supportdydrogesteronepregnancy ratesIVFintramuscular progesterone |
| spellingShingle | Virginie Simon Virginie Simon Geoffroy Robin Geoffroy Robin Laura Keller Camille Ternynck Camille Ternynck Sophie Jonard Sophie Jonard Camille Robin Christine Decanter Pauline Plouvier Systematic use of long-acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer: A pilot study Frontiers in Endocrinology luteal phase support dydrogesterone pregnancy rates IVF intramuscular progesterone |
| title | Systematic use of long-acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer: A pilot study |
| title_full | Systematic use of long-acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer: A pilot study |
| title_fullStr | Systematic use of long-acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer: A pilot study |
| title_full_unstemmed | Systematic use of long-acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer: A pilot study |
| title_short | Systematic use of long-acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer: A pilot study |
| title_sort | systematic use of long acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer a pilot study |
| topic | luteal phase support dydrogesterone pregnancy rates IVF intramuscular progesterone |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1039579/full |
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