Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying
In this present formulation study, vinpocetine-loaded nano-spray-dried polymeric micelles were developed via nano-spray-drying. Three different mucoadhesive excipients were applied in the studies, namely chitosan, hyaluronic acid and hydroxypropyl methylcellulose. In all cases, the formulations had...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/10/1447 |
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| author | Bence Sipos Gábor Katona Flóra Mária Szarvas Mária Budai-Szűcs Rita Ambrus Ildikó Csóka |
| author_facet | Bence Sipos Gábor Katona Flóra Mária Szarvas Mária Budai-Szűcs Rita Ambrus Ildikó Csóka |
| author_sort | Bence Sipos |
| collection | DOAJ |
| description | In this present formulation study, vinpocetine-loaded nano-spray-dried polymeric micelles were developed via nano-spray-drying. Three different mucoadhesive excipients were applied in the studies, namely chitosan, hyaluronic acid and hydroxypropyl methylcellulose. In all cases, the formulations had a proper particle size and drug content after drying with spherical morphology and amorphous structure. After rapid dissolution in water, the polymeric micelles had a particle size around 100–130 nm, in monodisperse size distribution. The high encapsulation efficiency (>80%) and high solubilization (approx. 300-fold increase in thermodynamic solubility) contributed to rapid drug release (>80% in the first 15 min) and fast passive diffusion at simulated nasal conditions. The formulated prototype preparations fulfilled the demands of a low-viscosity, moderately mucoadhesive nasal drug delivery system, which may be capable of increasing the overall bioavailability of drugs administered via the auspicious nasal drug delivery route. |
| first_indexed | 2024-03-10T20:59:06Z |
| format | Article |
| id | doaj.art-daa25b699a784f618ab7e683acba191b |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T20:59:06Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-daa25b699a784f618ab7e683acba191b2023-11-19T17:42:39ZengMDPI AGPharmaceuticals1424-82472023-10-011610144710.3390/ph16101447Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-DryingBence Sipos0Gábor Katona1Flóra Mária Szarvas2Mária Budai-Szűcs3Rita Ambrus4Ildikó Csóka5Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, H-6720 Szeged, HungaryIn this present formulation study, vinpocetine-loaded nano-spray-dried polymeric micelles were developed via nano-spray-drying. Three different mucoadhesive excipients were applied in the studies, namely chitosan, hyaluronic acid and hydroxypropyl methylcellulose. In all cases, the formulations had a proper particle size and drug content after drying with spherical morphology and amorphous structure. After rapid dissolution in water, the polymeric micelles had a particle size around 100–130 nm, in monodisperse size distribution. The high encapsulation efficiency (>80%) and high solubilization (approx. 300-fold increase in thermodynamic solubility) contributed to rapid drug release (>80% in the first 15 min) and fast passive diffusion at simulated nasal conditions. The formulated prototype preparations fulfilled the demands of a low-viscosity, moderately mucoadhesive nasal drug delivery system, which may be capable of increasing the overall bioavailability of drugs administered via the auspicious nasal drug delivery route.https://www.mdpi.com/1424-8247/16/10/1447polymeric micellenasal deliverynano-spray-dryingsolubility enhancementpermeability enhancementmucoadhesive polymer |
| spellingShingle | Bence Sipos Gábor Katona Flóra Mária Szarvas Mária Budai-Szűcs Rita Ambrus Ildikó Csóka Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying Pharmaceuticals polymeric micelle nasal delivery nano-spray-drying solubility enhancement permeability enhancement mucoadhesive polymer |
| title | Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying |
| title_full | Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying |
| title_fullStr | Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying |
| title_full_unstemmed | Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying |
| title_short | Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying |
| title_sort | development of vinpocetine loaded nasal polymeric micelles via nano spray drying |
| topic | polymeric micelle nasal delivery nano-spray-drying solubility enhancement permeability enhancement mucoadhesive polymer |
| url | https://www.mdpi.com/1424-8247/16/10/1447 |
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