Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis

Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis

Abstract Background The objective of this study was to determine if mechanistic target of rapamycin (mTOR) inhibition with or without AMP-activated protein kinase (AMPK) activation can protect against primary, age-related OA. Design Dunkin-Hartley guinea pigs develop mild primary OA pathology by 5 m...

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Bibliographic Details
Main Authors: Dennis M. Minton, Christian J. Elliehausen, Martin A. Javors, Kelly S. Santangello, Adam R. Konopka
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Arthritis Research & Therapy
Subjects:
Aging
mTOR
AMPK
Dunkin Hartley guinea pig
Primary osteoarthritis
Online Access:https://doi.org/10.1186/s13075-021-02637-1

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