Studying GPCR/cAMP pharmacology from the perspective of cellular structure

Studying GPCR/cAMP pharmacology from the perspective of cellular structure

Signal transduction via G-protein coupled receptors (GPCRs) relies upon the production of cAMP and other signaling cascades. A given receptor and agonist pair, produce multiple effects upon cellular physiology which can be opposite in different cell types. The production of variable cellular effect...

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Bibliographic Details
Main Authors: Peter T Wright, Sophie eSchobesberger, Julia eGorelik
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Pharmacology
Subjects:
Caveolae
lipid rafts
GPCRs
cAMP
FRET sensors
Compartmentation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00148/full

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