Genetic factors associated with the development of age-related macular degeneration
Age-related macular degeneration (AMD) affects the macula and is the leading cause of significant and irreversible central visual loss. It is the most common cause of visual loss in people aged more than 60 years. This disease affects 2.5 million individuals in Europe. AMD is caused by both environm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-01-01
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| Series: | Medicina |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1010660X16000227 |
| _version_ | 1797728231617462272 |
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| author | Olga Sergejeva Roman Botov Rasa Liutkevičienė Loresa Kriaučiūnienė |
| author_facet | Olga Sergejeva Roman Botov Rasa Liutkevičienė Loresa Kriaučiūnienė |
| author_sort | Olga Sergejeva |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) affects the macula and is the leading cause of significant and irreversible central visual loss. It is the most common cause of visual loss in people aged more than 60 years. This disease affects 2.5 million individuals in Europe. AMD is caused by both environmental and genetic factors. Numerous risk factors have been reported, but the pathogenesis of AMD is complex and fairly understood. Age, female gender, obesity, race, education status, family history, hyperopia, iris color, cigarette smoking, previous cataract surgery, history of cardiovascular and cerebrovascular disease, diabetes, sunlight exposure and many other factors have been shown to be associated with AMD development. Scientific evidence shows that genes may play a role in the development of nearly 3 out of 4 cases of this devastating eye disease. The genes that have been shown to be associated with AMD are genes encoding complement system components such as CFH, C2, C3, CFB, and other. |
| first_indexed | 2024-03-12T11:11:03Z |
| format | Article |
| id | doaj.art-daa3c17080da462993be8bd34d82e4fe |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:11:03Z |
| publishDate | 2016-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-daa3c17080da462993be8bd34d82e4fe2023-09-02T02:55:36ZengMDPI AGMedicina1010-660X2016-01-01522798810.1016/j.medici.2016.02.004Genetic factors associated with the development of age-related macular degenerationOlga Sergejeva0Roman Botov1Rasa Liutkevičienė2Loresa Kriaučiūnienė3Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaFaculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaLaboratory of Ophthalmology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaAge-related macular degeneration (AMD) affects the macula and is the leading cause of significant and irreversible central visual loss. It is the most common cause of visual loss in people aged more than 60 years. This disease affects 2.5 million individuals in Europe. AMD is caused by both environmental and genetic factors. Numerous risk factors have been reported, but the pathogenesis of AMD is complex and fairly understood. Age, female gender, obesity, race, education status, family history, hyperopia, iris color, cigarette smoking, previous cataract surgery, history of cardiovascular and cerebrovascular disease, diabetes, sunlight exposure and many other factors have been shown to be associated with AMD development. Scientific evidence shows that genes may play a role in the development of nearly 3 out of 4 cases of this devastating eye disease. The genes that have been shown to be associated with AMD are genes encoding complement system components such as CFH, C2, C3, CFB, and other.http://www.sciencedirect.com/science/article/pii/S1010660X16000227Early and late age-related macular degenerationRisk factorsGenes |
| spellingShingle | Olga Sergejeva Roman Botov Rasa Liutkevičienė Loresa Kriaučiūnienė Genetic factors associated with the development of age-related macular degeneration Medicina Early and late age-related macular degeneration Risk factors Genes |
| title | Genetic factors associated with the development of age-related macular degeneration |
| title_full | Genetic factors associated with the development of age-related macular degeneration |
| title_fullStr | Genetic factors associated with the development of age-related macular degeneration |
| title_full_unstemmed | Genetic factors associated with the development of age-related macular degeneration |
| title_short | Genetic factors associated with the development of age-related macular degeneration |
| title_sort | genetic factors associated with the development of age related macular degeneration |
| topic | Early and late age-related macular degeneration Risk factors Genes |
| url | http://www.sciencedirect.com/science/article/pii/S1010660X16000227 |
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