Hylocereus undatus flower suppresses DSS-induced colitis in mice by reducing intestinal inflammation, repairing the intestinal physical barrier, and modulating gut and lung microbiota
The Hylocereus undatus flower (HUF) is an herb with significant anti-inflammatory and immunomodulatory activity. It can be used as a food or a medicine and is beneficial to the gut and lung, which recent evidence has suggested interact through the gut–lung axis. This study investigated both the prot...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623004206 |
| _version_ | 1797632730120323072 |
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| author | Wanzhong Liao Huafeng Wu Liangcheng Pang Bizuan He Jianjun Tong Jiuyun Qin Liang Li Wei Liu Xianqiang Zhou Sihua Huang Weizhe Jiang Shujie Fu |
| author_facet | Wanzhong Liao Huafeng Wu Liangcheng Pang Bizuan He Jianjun Tong Jiuyun Qin Liang Li Wei Liu Xianqiang Zhou Sihua Huang Weizhe Jiang Shujie Fu |
| author_sort | Wanzhong Liao |
| collection | DOAJ |
| description | The Hylocereus undatus flower (HUF) is an herb with significant anti-inflammatory and immunomodulatory activity. It can be used as a food or a medicine and is beneficial to the gut and lung, which recent evidence has suggested interact through the gut–lung axis. This study investigated both the protective effect of HUF against DSS-induced colitis and its mechanism. The results showed that HUF significantly alleviated the symptoms of UC, maintained the normal functioning of the intestinal barrier, and ameliorated abnormally elevated inflammatory response, thereby repairing the damaged gut microenvironment and protecting the composition of the original gut microbiota. Interestingly, possibly related to the role of the gut–lung axis, HUF improved the disturbance of the lung microbiota and reduced lung injury in UC mice. To conclude, HUF alleviates colitis by restoring the integrity of the intestinal barrier, reducing the inflammatory response, and regulating gut and lung microbiota. |
| first_indexed | 2024-03-11T11:41:56Z |
| format | Article |
| id | doaj.art-daa3c9070ac149a89fe8da3952c2440a |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-11T11:41:56Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-daa3c9070ac149a89fe8da3952c2440a2023-11-10T04:16:07ZengElsevierJournal of Functional Foods1756-46462023-11-01110105820Hylocereus undatus flower suppresses DSS-induced colitis in mice by reducing intestinal inflammation, repairing the intestinal physical barrier, and modulating gut and lung microbiotaWanzhong Liao0Huafeng Wu1Liangcheng Pang2Bizuan He3Jianjun Tong4Jiuyun Qin5Liang Li6Wei Liu7Xianqiang Zhou8Sihua Huang9Weizhe Jiang10Shujie Fu11Pharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaPharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaPharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaPharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaPharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaPharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaPharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaPharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaPharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaPharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaCorresponding authors.; Pharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaCorresponding authors.; Pharmaceutical College, Guangxi Medical University, Nanning 530021, ChinaThe Hylocereus undatus flower (HUF) is an herb with significant anti-inflammatory and immunomodulatory activity. It can be used as a food or a medicine and is beneficial to the gut and lung, which recent evidence has suggested interact through the gut–lung axis. This study investigated both the protective effect of HUF against DSS-induced colitis and its mechanism. The results showed that HUF significantly alleviated the symptoms of UC, maintained the normal functioning of the intestinal barrier, and ameliorated abnormally elevated inflammatory response, thereby repairing the damaged gut microenvironment and protecting the composition of the original gut microbiota. Interestingly, possibly related to the role of the gut–lung axis, HUF improved the disturbance of the lung microbiota and reduced lung injury in UC mice. To conclude, HUF alleviates colitis by restoring the integrity of the intestinal barrier, reducing the inflammatory response, and regulating gut and lung microbiota.http://www.sciencedirect.com/science/article/pii/S1756464623004206Ulcerative colitisGut microbiotaHylocereus undatus flowerLung microbiota |
| spellingShingle | Wanzhong Liao Huafeng Wu Liangcheng Pang Bizuan He Jianjun Tong Jiuyun Qin Liang Li Wei Liu Xianqiang Zhou Sihua Huang Weizhe Jiang Shujie Fu Hylocereus undatus flower suppresses DSS-induced colitis in mice by reducing intestinal inflammation, repairing the intestinal physical barrier, and modulating gut and lung microbiota Journal of Functional Foods Ulcerative colitis Gut microbiota Hylocereus undatus flower Lung microbiota |
| title | Hylocereus undatus flower suppresses DSS-induced colitis in mice by reducing intestinal inflammation, repairing the intestinal physical barrier, and modulating gut and lung microbiota |
| title_full | Hylocereus undatus flower suppresses DSS-induced colitis in mice by reducing intestinal inflammation, repairing the intestinal physical barrier, and modulating gut and lung microbiota |
| title_fullStr | Hylocereus undatus flower suppresses DSS-induced colitis in mice by reducing intestinal inflammation, repairing the intestinal physical barrier, and modulating gut and lung microbiota |
| title_full_unstemmed | Hylocereus undatus flower suppresses DSS-induced colitis in mice by reducing intestinal inflammation, repairing the intestinal physical barrier, and modulating gut and lung microbiota |
| title_short | Hylocereus undatus flower suppresses DSS-induced colitis in mice by reducing intestinal inflammation, repairing the intestinal physical barrier, and modulating gut and lung microbiota |
| title_sort | hylocereus undatus flower suppresses dss induced colitis in mice by reducing intestinal inflammation repairing the intestinal physical barrier and modulating gut and lung microbiota |
| topic | Ulcerative colitis Gut microbiota Hylocereus undatus flower Lung microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623004206 |
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