Revealing clinically relevant specific IgE sensitization patterns in Hymenoptera venom allergy with dimension reduction and clusteringKey messagesCapsule summary
Background: Immunoglobulin E (IgE) blood tests are used to detect sensitizations and potential allergies. Recent studies suggest that specific IgE sensitization patterns due to molecular interactions affect an individual's risk of developing allergic symptoms. Objective: The aim of this study w...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | World Allergy Organization Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455123000807 |
| _version_ | 1797637282790899712 |
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| author | Robert Kaczmarczyk, MD Tobias Lasser, PhD Tilo Biedermann, MD Johannes Ring, MD Alexander Zink, MD |
| author_facet | Robert Kaczmarczyk, MD Tobias Lasser, PhD Tilo Biedermann, MD Johannes Ring, MD Alexander Zink, MD |
| author_sort | Robert Kaczmarczyk, MD |
| collection | DOAJ |
| description | Background: Immunoglobulin E (IgE) blood tests are used to detect sensitizations and potential allergies. Recent studies suggest that specific IgE sensitization patterns due to molecular interactions affect an individual's risk of developing allergic symptoms. Objective: The aim of this study was to reveal specific IgE sensitization patterns and investigate their clinical implications in Hymenoptera venom allergy. Methods: In this cross-sectional study, 257 hunters or fishers with self-filled surveys on previous Hymenoptera stings were analyzed. Blood samples were taken to determine Hymenoptera IgE sensitization levels. Using dimensionality reduction and clustering, specific IgE for 10 Hymenoptera venom allergens were evaluated for clinical relevance. Results: Three clusters were unmasked using novel dimensionality reduction and clustering methods solely based on specific IgE levels to Hymenoptera venom allergens. These clusters show different characteristics regarding previous systemic reactions to Hymenoptera stings. Conclusion: Our study was able to unmask non-linear sensitization patterns for specific IgE tests in Hymenoptera venom allergy. We were able to derive risk clusters for anaphylactic reactions following hymenoptera stings and pinpoint relevant allergens (rApi m 10, rVes v 1, whole bee, and wasp venom) for clustering. |
| first_indexed | 2024-03-11T12:47:07Z |
| format | Article |
| id | doaj.art-daa4c221062b4383ac8e6da301952ad3 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-03-11T12:47:07Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-daa4c221062b4383ac8e6da301952ad32023-11-05T04:05:26ZengElsevierWorld Allergy Organization Journal1939-45512023-10-011610100820Revealing clinically relevant specific IgE sensitization patterns in Hymenoptera venom allergy with dimension reduction and clusteringKey messagesCapsule summaryRobert Kaczmarczyk, MD0Tobias Lasser, PhD1Tilo Biedermann, MD2Johannes Ring, MD3Alexander Zink, MD4Technical University of Munich, School of Medicine, Department of Dermatology and Allergy, Munich, Germany; Corresponding author.Technical University of Munich, School of Computation, Information and Technology, Department of Informatics, Munich Institute of Biomedical Engineering, Munich, GermanyTechnical University of Munich, School of Medicine, Department of Dermatology and Allergy, Munich, GermanyTechnical University of Munich, School of Medicine, Department of Dermatology and Allergy, Munich, GermanyTechnical University of Munich, School of Medicine, Department of Dermatology and Allergy, Munich, Germany; Division of Dermatology and Venereology, Department of Medicine Solna, Karolinska Institutet, 17176, Stockholm, SwedenBackground: Immunoglobulin E (IgE) blood tests are used to detect sensitizations and potential allergies. Recent studies suggest that specific IgE sensitization patterns due to molecular interactions affect an individual's risk of developing allergic symptoms. Objective: The aim of this study was to reveal specific IgE sensitization patterns and investigate their clinical implications in Hymenoptera venom allergy. Methods: In this cross-sectional study, 257 hunters or fishers with self-filled surveys on previous Hymenoptera stings were analyzed. Blood samples were taken to determine Hymenoptera IgE sensitization levels. Using dimensionality reduction and clustering, specific IgE for 10 Hymenoptera venom allergens were evaluated for clinical relevance. Results: Three clusters were unmasked using novel dimensionality reduction and clustering methods solely based on specific IgE levels to Hymenoptera venom allergens. These clusters show different characteristics regarding previous systemic reactions to Hymenoptera stings. Conclusion: Our study was able to unmask non-linear sensitization patterns for specific IgE tests in Hymenoptera venom allergy. We were able to derive risk clusters for anaphylactic reactions following hymenoptera stings and pinpoint relevant allergens (rApi m 10, rVes v 1, whole bee, and wasp venom) for clustering.http://www.sciencedirect.com/science/article/pii/S1939455123000807Hymenoptera venom allergySpecific IgERisk assessmentCohort-study |
| spellingShingle | Robert Kaczmarczyk, MD Tobias Lasser, PhD Tilo Biedermann, MD Johannes Ring, MD Alexander Zink, MD Revealing clinically relevant specific IgE sensitization patterns in Hymenoptera venom allergy with dimension reduction and clusteringKey messagesCapsule summary World Allergy Organization Journal Hymenoptera venom allergy Specific IgE Risk assessment Cohort-study |
| title | Revealing clinically relevant specific IgE sensitization patterns in Hymenoptera venom allergy with dimension reduction and clusteringKey messagesCapsule summary |
| title_full | Revealing clinically relevant specific IgE sensitization patterns in Hymenoptera venom allergy with dimension reduction and clusteringKey messagesCapsule summary |
| title_fullStr | Revealing clinically relevant specific IgE sensitization patterns in Hymenoptera venom allergy with dimension reduction and clusteringKey messagesCapsule summary |
| title_full_unstemmed | Revealing clinically relevant specific IgE sensitization patterns in Hymenoptera venom allergy with dimension reduction and clusteringKey messagesCapsule summary |
| title_short | Revealing clinically relevant specific IgE sensitization patterns in Hymenoptera venom allergy with dimension reduction and clusteringKey messagesCapsule summary |
| title_sort | revealing clinically relevant specific ige sensitization patterns in hymenoptera venom allergy with dimension reduction and clusteringkey messagescapsule summary |
| topic | Hymenoptera venom allergy Specific IgE Risk assessment Cohort-study |
| url | http://www.sciencedirect.com/science/article/pii/S1939455123000807 |
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