The Role of N<sup>6</sup>-Methyladenosine Modification in Microvascular Dysfunction
Microvascular dysfunction (MVD) has long plagued the medical field despite improvements in its prevention, diagnosis, and intervention. Microvascular lesions from MVD increase with age and further lead to impaired microcirculation, target organ dysfunction, and a mass of microvascular complications,...
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MDPI AG
2022-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/20/3193 |
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| author | Ye-Ran Zhang Jiang-Dong Ji Jia-Nan Wang Ying Wang Hong-Jing Zhu Ru-Xu Sun Qing-Huai Liu Xue Chen |
| author_facet | Ye-Ran Zhang Jiang-Dong Ji Jia-Nan Wang Ying Wang Hong-Jing Zhu Ru-Xu Sun Qing-Huai Liu Xue Chen |
| author_sort | Ye-Ran Zhang |
| collection | DOAJ |
| description | Microvascular dysfunction (MVD) has long plagued the medical field despite improvements in its prevention, diagnosis, and intervention. Microvascular lesions from MVD increase with age and further lead to impaired microcirculation, target organ dysfunction, and a mass of microvascular complications, thus contributing to a heavy medical burden and rising disability rates. An up-to-date understanding of molecular mechanisms underlying MVD will facilitate discoveries of more effective therapeutic strategies. Recent advances in epigenetics have revealed that RNA methylation, an epigenetic modification, has a pivotal role in vascular events. The N<sup>6</sup>-methylation of adenosine (m<sup>6</sup>A) modification is the most prevalent internal RNA modification in eukaryotic cells, which regulates vascular transcripts through splicing, degradation, translation, as well as translocation, thus maintaining microvascular homeostasis. Conversely, the disruption of the m<sup>6</sup>A regulatory network will lead to MVD. Herein, we provide a review discussing how m<sup>6</sup>A methylation interacts with MVD. We also focus on alterations of the m<sup>6</sup>A regulatory network under pathological conditions. Finally, we highlight the value of m<sup>6</sup>A regulators as prognostic biomarkers and novel therapeutic targets, which might be a promising addition to clinical medicine. |
| first_indexed | 2024-03-09T20:29:34Z |
| format | Article |
| id | doaj.art-daa4e6f78fe7469c88ebd8fb4fe61a62 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T20:29:34Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-daa4e6f78fe7469c88ebd8fb4fe61a622023-11-23T23:27:06ZengMDPI AGCells2073-44092022-10-011120319310.3390/cells11203193The Role of N<sup>6</sup>-Methyladenosine Modification in Microvascular DysfunctionYe-Ran Zhang0Jiang-Dong Ji1Jia-Nan Wang2Ying Wang3Hong-Jing Zhu4Ru-Xu Sun5Qing-Huai Liu6Xue Chen7Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, ChinaMicrovascular dysfunction (MVD) has long plagued the medical field despite improvements in its prevention, diagnosis, and intervention. Microvascular lesions from MVD increase with age and further lead to impaired microcirculation, target organ dysfunction, and a mass of microvascular complications, thus contributing to a heavy medical burden and rising disability rates. An up-to-date understanding of molecular mechanisms underlying MVD will facilitate discoveries of more effective therapeutic strategies. Recent advances in epigenetics have revealed that RNA methylation, an epigenetic modification, has a pivotal role in vascular events. The N<sup>6</sup>-methylation of adenosine (m<sup>6</sup>A) modification is the most prevalent internal RNA modification in eukaryotic cells, which regulates vascular transcripts through splicing, degradation, translation, as well as translocation, thus maintaining microvascular homeostasis. Conversely, the disruption of the m<sup>6</sup>A regulatory network will lead to MVD. Herein, we provide a review discussing how m<sup>6</sup>A methylation interacts with MVD. We also focus on alterations of the m<sup>6</sup>A regulatory network under pathological conditions. Finally, we highlight the value of m<sup>6</sup>A regulators as prognostic biomarkers and novel therapeutic targets, which might be a promising addition to clinical medicine.https://www.mdpi.com/2073-4409/11/20/3193N<sup>6</sup>-methyladenosine modificationangiogenesismicrovascular dysfunctionsepigenetics |
| spellingShingle | Ye-Ran Zhang Jiang-Dong Ji Jia-Nan Wang Ying Wang Hong-Jing Zhu Ru-Xu Sun Qing-Huai Liu Xue Chen The Role of N<sup>6</sup>-Methyladenosine Modification in Microvascular Dysfunction Cells N<sup>6</sup>-methyladenosine modification angiogenesis microvascular dysfunctions epigenetics |
| title | The Role of N<sup>6</sup>-Methyladenosine Modification in Microvascular Dysfunction |
| title_full | The Role of N<sup>6</sup>-Methyladenosine Modification in Microvascular Dysfunction |
| title_fullStr | The Role of N<sup>6</sup>-Methyladenosine Modification in Microvascular Dysfunction |
| title_full_unstemmed | The Role of N<sup>6</sup>-Methyladenosine Modification in Microvascular Dysfunction |
| title_short | The Role of N<sup>6</sup>-Methyladenosine Modification in Microvascular Dysfunction |
| title_sort | role of n sup 6 sup methyladenosine modification in microvascular dysfunction |
| topic | N<sup>6</sup>-methyladenosine modification angiogenesis microvascular dysfunctions epigenetics |
| url | https://www.mdpi.com/2073-4409/11/20/3193 |
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