Pharmacological limitations of phage therapy
Clinical trial results of phage treatment of bacterial infections show a low to moderate efficacy, and the variation in infection clearance between subjects within studies is often large. Phage therapy is complicated and introduces many additional components of variance as compared to antibiotic tre...
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| Format: | Article |
| Language: | English |
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Upsala Medical Society
2019-10-01
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| Series: | Upsala Journal of Medical Sciences |
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| Online Access: | http://dx.doi.org/10.1080/03009734.2019.1688433 |
| _version_ | 1827851175621296128 |
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| author | Anders S. Nilsson |
| author_facet | Anders S. Nilsson |
| author_sort | Anders S. Nilsson |
| collection | DOAJ |
| description | Clinical trial results of phage treatment of bacterial infections show a low to moderate efficacy, and the variation in infection clearance between subjects within studies is often large. Phage therapy is complicated and introduces many additional components of variance as compared to antibiotic treatment. A large part of the variation is due to in vivo pharmacokinetics and pharmacodynamics being virtually unknown, but also to a lack of standardisation. This is a consequence of the great variation of phages, bacteria, and infections, which results in different experiments or trials being impossible to compare, and difficulties in estimating important parameter values in a quantitative and reproducible way. The limitations of phage therapy will have to be recognised and future research focussed on optimising infection clearance rates by e.g. selecting phages, bacteria, and target bacterial infections where the prospects of high efficacy can be anticipated, and by combining information from new mathematical modelling of in vivo pharmacokinetic and pharmacodynamic processes and quantitatively assessed experiments. |
| first_indexed | 2024-03-12T10:28:13Z |
| format | Article |
| id | doaj.art-daa9032e15584ccdb6e7dfc4c9f12cdc |
| institution | Directory Open Access Journal |
| issn | 0300-9734 2000-1967 |
| language | English |
| last_indexed | 2024-03-12T10:28:13Z |
| publishDate | 2019-10-01 |
| publisher | Upsala Medical Society |
| record_format | Article |
| series | Upsala Journal of Medical Sciences |
| spelling | doaj.art-daa9032e15584ccdb6e7dfc4c9f12cdc2023-09-02T09:31:11ZengUpsala Medical SocietyUpsala Journal of Medical Sciences0300-97342000-19672019-10-01124421822710.1080/03009734.2019.16884331688433Pharmacological limitations of phage therapyAnders S. Nilsson0Stockholm UniversityClinical trial results of phage treatment of bacterial infections show a low to moderate efficacy, and the variation in infection clearance between subjects within studies is often large. Phage therapy is complicated and introduces many additional components of variance as compared to antibiotic treatment. A large part of the variation is due to in vivo pharmacokinetics and pharmacodynamics being virtually unknown, but also to a lack of standardisation. This is a consequence of the great variation of phages, bacteria, and infections, which results in different experiments or trials being impossible to compare, and difficulties in estimating important parameter values in a quantitative and reproducible way. The limitations of phage therapy will have to be recognised and future research focussed on optimising infection clearance rates by e.g. selecting phages, bacteria, and target bacterial infections where the prospects of high efficacy can be anticipated, and by combining information from new mathematical modelling of in vivo pharmacokinetic and pharmacodynamic processes and quantitatively assessed experiments.http://dx.doi.org/10.1080/03009734.2019.1688433bacteriophagephage therapypharmacodynamicspharmacokineticspharmacology |
| spellingShingle | Anders S. Nilsson Pharmacological limitations of phage therapy Upsala Journal of Medical Sciences bacteriophage phage therapy pharmacodynamics pharmacokinetics pharmacology |
| title | Pharmacological limitations of phage therapy |
| title_full | Pharmacological limitations of phage therapy |
| title_fullStr | Pharmacological limitations of phage therapy |
| title_full_unstemmed | Pharmacological limitations of phage therapy |
| title_short | Pharmacological limitations of phage therapy |
| title_sort | pharmacological limitations of phage therapy |
| topic | bacteriophage phage therapy pharmacodynamics pharmacokinetics pharmacology |
| url | http://dx.doi.org/10.1080/03009734.2019.1688433 |
| work_keys_str_mv | AT anderssnilsson pharmacologicallimitationsofphagetherapy |