Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation?
In recent years, there has been considerable research showing that coffee consumption seems to be beneficial to human health, as it contains a mixture of different bioactive compounds such as chlorogenic acids, caffeic acid, alkaloids, diterpenes and polyphenols. Neurodegenerative diseases (NDs) are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/12958 |
| _version_ | 1797468050468896768 |
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| author | Melania Ruggiero Rosa Calvello Chiara Porro Giovanni Messina Antonia Cianciulli Maria Antonietta Panaro |
| author_facet | Melania Ruggiero Rosa Calvello Chiara Porro Giovanni Messina Antonia Cianciulli Maria Antonietta Panaro |
| author_sort | Melania Ruggiero |
| collection | DOAJ |
| description | In recent years, there has been considerable research showing that coffee consumption seems to be beneficial to human health, as it contains a mixture of different bioactive compounds such as chlorogenic acids, caffeic acid, alkaloids, diterpenes and polyphenols. Neurodegenerative diseases (NDs) are debilitating, and non-curable diseases associated with impaired central, peripheral and muscle nervous systems. Several studies demonstrate that neuroinflammation mediated by glial cells—such as microglia and astrocytes—is a critical factor contributing to neurodegeneration that causes the dysfunction of brain homeostasis, resulting in a progressive loss of structure, function, and number of neuronal cells. This happens over time and leads to brain damage and physical impairment. The most known chronic NDs are represented by Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). According to epidemiological studies, regular coffee consumption is associated with a lower risk of neurodegenerative diseases. In this review, we summarize the latest research about the potential effects of caffeine in neurodegenerative disorders prevention and discuss the role of controlled caffeine delivery systems in maintaining high plasma caffeine concentrations for an extended time. |
| first_indexed | 2024-03-09T19:02:00Z |
| format | Article |
| id | doaj.art-daab43704baa463db383efe3a108c93a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:02:00Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-daab43704baa463db383efe3a108c93a2023-11-24T05:00:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123211295810.3390/ijms232112958Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation?Melania Ruggiero0Rosa Calvello1Chiara Porro2Giovanni Messina3Antonia Cianciulli4Maria Antonietta Panaro5Department of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, ItalyDepartment of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, ItalyDepartment of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, ItalyDepartment of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, ItalyIn recent years, there has been considerable research showing that coffee consumption seems to be beneficial to human health, as it contains a mixture of different bioactive compounds such as chlorogenic acids, caffeic acid, alkaloids, diterpenes and polyphenols. Neurodegenerative diseases (NDs) are debilitating, and non-curable diseases associated with impaired central, peripheral and muscle nervous systems. Several studies demonstrate that neuroinflammation mediated by glial cells—such as microglia and astrocytes—is a critical factor contributing to neurodegeneration that causes the dysfunction of brain homeostasis, resulting in a progressive loss of structure, function, and number of neuronal cells. This happens over time and leads to brain damage and physical impairment. The most known chronic NDs are represented by Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). According to epidemiological studies, regular coffee consumption is associated with a lower risk of neurodegenerative diseases. In this review, we summarize the latest research about the potential effects of caffeine in neurodegenerative disorders prevention and discuss the role of controlled caffeine delivery systems in maintaining high plasma caffeine concentrations for an extended time.https://www.mdpi.com/1422-0067/23/21/12958caffeineneurodegenerative diseasesneuroinflammationimmune responseneuroprotection |
| spellingShingle | Melania Ruggiero Rosa Calvello Chiara Porro Giovanni Messina Antonia Cianciulli Maria Antonietta Panaro Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation? International Journal of Molecular Sciences caffeine neurodegenerative diseases neuroinflammation immune response neuroprotection |
| title | Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation? |
| title_full | Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation? |
| title_fullStr | Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation? |
| title_full_unstemmed | Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation? |
| title_short | Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation? |
| title_sort | neurodegenerative diseases can caffeine be a powerful ally to weaken neuroinflammation |
| topic | caffeine neurodegenerative diseases neuroinflammation immune response neuroprotection |
| url | https://www.mdpi.com/1422-0067/23/21/12958 |
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