Polyamines: their significance for maintaining health and contributing to diseases
Abstract Polyamines are essential for the growth and proliferation of mammalian cells and are intimately involved in biological mechanisms such as DNA replication, RNA transcription, protein synthesis, and post-translational modification. These mechanisms regulate cellular proliferation, differentia...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01373-0 |
| _version_ | 1797397910060531712 |
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| author | Mengjuan Xuan Xinyu Gu Juan Li Di Huang Chen Xue Yuting He |
| author_facet | Mengjuan Xuan Xinyu Gu Juan Li Di Huang Chen Xue Yuting He |
| author_sort | Mengjuan Xuan |
| collection | DOAJ |
| description | Abstract Polyamines are essential for the growth and proliferation of mammalian cells and are intimately involved in biological mechanisms such as DNA replication, RNA transcription, protein synthesis, and post-translational modification. These mechanisms regulate cellular proliferation, differentiation, programmed cell death, and the formation of tumors. Several studies have confirmed the positive effect of polyamines on the maintenance of health, while others have demonstrated that their activity may promote the occurrence and progression of diseases. This review examines a variety of topics, such as polyamine source and metabolism, including metabolism, transport, and the potential impact of polyamines on health and disease. In addition, a brief summary of the effects of oncogenes and signaling pathways on tumor polyamine metabolism is provided. Video Abstract |
| first_indexed | 2024-03-09T01:17:01Z |
| format | Article |
| id | doaj.art-daad5187776844c8af6943cc8b3fa765 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-09T01:17:01Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-daad5187776844c8af6943cc8b3fa7652023-12-10T12:26:22ZengBMCCell Communication and Signaling1478-811X2023-12-0121112410.1186/s12964-023-01373-0Polyamines: their significance for maintaining health and contributing to diseasesMengjuan Xuan0Xinyu Gu1Juan Li2Di Huang3Chen Xue4Yuting He5Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Oncology, College of Clinical Medicine, The First Affiliated Hospital, Henan University of Science and TechnologyDepartment of Infectious Disease, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Child Health Care, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Infectious Disease, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou UniversityAbstract Polyamines are essential for the growth and proliferation of mammalian cells and are intimately involved in biological mechanisms such as DNA replication, RNA transcription, protein synthesis, and post-translational modification. These mechanisms regulate cellular proliferation, differentiation, programmed cell death, and the formation of tumors. Several studies have confirmed the positive effect of polyamines on the maintenance of health, while others have demonstrated that their activity may promote the occurrence and progression of diseases. This review examines a variety of topics, such as polyamine source and metabolism, including metabolism, transport, and the potential impact of polyamines on health and disease. In addition, a brief summary of the effects of oncogenes and signaling pathways on tumor polyamine metabolism is provided. Video Abstracthttps://doi.org/10.1186/s12964-023-01373-0Polyamine metabolismDiseaseCancerOncogeneMechanism |
| spellingShingle | Mengjuan Xuan Xinyu Gu Juan Li Di Huang Chen Xue Yuting He Polyamines: their significance for maintaining health and contributing to diseases Cell Communication and Signaling Polyamine metabolism Disease Cancer Oncogene Mechanism |
| title | Polyamines: their significance for maintaining health and contributing to diseases |
| title_full | Polyamines: their significance for maintaining health and contributing to diseases |
| title_fullStr | Polyamines: their significance for maintaining health and contributing to diseases |
| title_full_unstemmed | Polyamines: their significance for maintaining health and contributing to diseases |
| title_short | Polyamines: their significance for maintaining health and contributing to diseases |
| title_sort | polyamines their significance for maintaining health and contributing to diseases |
| topic | Polyamine metabolism Disease Cancer Oncogene Mechanism |
| url | https://doi.org/10.1186/s12964-023-01373-0 |
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