SKAP2—A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and Function
Src-kinase associated protein 2 (SKAP2) is an intracellular scaffolding protein that is broadly expressed in immune cells and is involved in various downstream signalling pathways, including, but not limited to, integrin signalling. SKAP2 has a wide range of binding partners and fine-tunes the rearr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/10/2788 |
| _version_ | 1827721639459028992 |
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| author | Marijn Wilmink Marianne Rebecca Spalinger |
| author_facet | Marijn Wilmink Marianne Rebecca Spalinger |
| author_sort | Marijn Wilmink |
| collection | DOAJ |
| description | Src-kinase associated protein 2 (SKAP2) is an intracellular scaffolding protein that is broadly expressed in immune cells and is involved in various downstream signalling pathways, including, but not limited to, integrin signalling. SKAP2 has a wide range of binding partners and fine-tunes the rearrangement of the cytoskeleton, thereby regulating cell migration and immune cell function. Mutations in SKAP2 have been associated with several inflammatory disorders such as Type 1 Diabetes and Crohn’s disease. Rodent studies showed that SKAP2 deficient immune cells have diminished pathogen clearance due to impaired ROS production and/or phagocytosis. However, there is currently no in-depth understanding of the functioning of SKAP2. Nevertheless, this review summarises the existing knowledge with a focus of its role in signalling cascades involved in cell migration, tissue infiltration and immune cell function. |
| first_indexed | 2024-03-10T21:24:53Z |
| format | Article |
| id | doaj.art-daae8645d669456091a8f966fc8285de |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T21:24:53Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-daae8645d669456091a8f966fc8285de2023-11-19T15:47:07ZengMDPI AGBiomedicines2227-90592023-10-011110278810.3390/biomedicines11102788SKAP2—A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and FunctionMarijn Wilmink0Marianne Rebecca Spalinger1Department for Gastroenterology and Hepatology, University Hospital Zürich, Sternwartstrasse 14, 8091 Zürich, SwitzerlandDepartment for Gastroenterology and Hepatology, University Hospital Zürich, Sternwartstrasse 14, 8091 Zürich, SwitzerlandSrc-kinase associated protein 2 (SKAP2) is an intracellular scaffolding protein that is broadly expressed in immune cells and is involved in various downstream signalling pathways, including, but not limited to, integrin signalling. SKAP2 has a wide range of binding partners and fine-tunes the rearrangement of the cytoskeleton, thereby regulating cell migration and immune cell function. Mutations in SKAP2 have been associated with several inflammatory disorders such as Type 1 Diabetes and Crohn’s disease. Rodent studies showed that SKAP2 deficient immune cells have diminished pathogen clearance due to impaired ROS production and/or phagocytosis. However, there is currently no in-depth understanding of the functioning of SKAP2. Nevertheless, this review summarises the existing knowledge with a focus of its role in signalling cascades involved in cell migration, tissue infiltration and immune cell function.https://www.mdpi.com/2227-9059/11/10/2788integrin signallingSrc-kinase associated protein 2SKAP55-HOMmacrophage function |
| spellingShingle | Marijn Wilmink Marianne Rebecca Spalinger SKAP2—A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and Function Biomedicines integrin signalling Src-kinase associated protein 2 SKAP55-HOM macrophage function |
| title | SKAP2—A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and Function |
| title_full | SKAP2—A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and Function |
| title_fullStr | SKAP2—A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and Function |
| title_full_unstemmed | SKAP2—A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and Function |
| title_short | SKAP2—A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and Function |
| title_sort | skap2 a molecule at the crossroads for integrin signalling and immune cell migration and function |
| topic | integrin signalling Src-kinase associated protein 2 SKAP55-HOM macrophage function |
| url | https://www.mdpi.com/2227-9059/11/10/2788 |
| work_keys_str_mv | AT marijnwilmink skap2amoleculeatthecrossroadsforintegrinsignallingandimmunecellmigrationandfunction AT mariannerebeccaspalinger skap2amoleculeatthecrossroadsforintegrinsignallingandimmunecellmigrationandfunction |