Novel prognostic markers within the CD44‐stromal ligand network in pancreatic cancer

Novel prognostic markers within the CD44‐stromal ligand network in pancreatic cancer

Abstract The dense stroma in pancreatic cancer tumours is rich in secreted extracellular matrix proteins and proteoglycans. Secreted hyaluronan, osteopontin and type IV collagen sustain oncogenic signalling by interactions with CD44s and its variant isoform CD44v6 on cancer cell membranes. Although...

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Bibliographic Details
Main Authors: Oskar Franklin, Ola Billing, Daniel Öhlund, Anette Berglund, Carl Herdenberg, Wanzhong Wang, Urban Hellman, Malin Sund
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:The Journal of Pathology: Clinical Research
Subjects:
pancreatic cancer
CD44
hyaluronan
type IV collagen
osteopontin
biomarkers
Online Access:https://doi.org/10.1002/cjp2.122

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