Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trials
Abstract Background Recent studies have shown conflicting results regarding the effect of hydrogel coils for treating intracranial aneurysm compared to bare platinum coils. We implemented a meta-analysis to assess the value of hydrogel coils in intracranial aneurysm treatment. Methods The MEDLINE, E...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | BMC Neurology |
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| Online Access: | http://link.springer.com/article/10.1186/s12883-018-1171-8 |
| _version_ | 1811208647991099392 |
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| author | Tao Xue Zhouqing Chen Weiwei Lin Jiayi Xu Xuming Shen Zhong Wang |
| author_facet | Tao Xue Zhouqing Chen Weiwei Lin Jiayi Xu Xuming Shen Zhong Wang |
| author_sort | Tao Xue |
| collection | DOAJ |
| description | Abstract Background Recent studies have shown conflicting results regarding the effect of hydrogel coils for treating intracranial aneurysm compared to bare platinum coils. We implemented a meta-analysis to assess the value of hydrogel coils in intracranial aneurysm treatment. Methods The MEDLINE, EMBASE, and Cochrane Library databases were searched for randomized controlled trials (RCTs) which had evaluated hydrogel coils versus bare platinum coils for intracranial aneurysms. Results We pooled 1526 patients from 4 RCTs with the mean follow-up time of more than 16 months. Hydrogel coils had reductions on mid-term recurrence (RR 0.78, 95% CI 0.65 to 0.94, P = 0.008) and residual aneurysm (RR 0.71, 95% CI 0.57 to 0.88, P = 0.002), but didn’t show any significant differences in other favorable outcomes such as functional recovery, mortality and so on. In the subgroup analysis, we found that second-generation hydrogel coils might exhibit potential impacts on increasing mid-term complete occlusion (RR 1.26, 95% CI 1.07 to 1.48, P = 0.005) and decreasing residual aneurysm neck. (RR 0.54, 95% CI 0.34 to 0.86, P = 0.010). Conclusions Hydrogel coils showed no significant efficacy on functional recovery but exhibited a lower rate of recurrences and residual aneurysms in patients with intracranial aneurysms. |
| first_indexed | 2024-04-12T04:25:00Z |
| format | Article |
| id | doaj.art-dab0b37b050c4464a0265e9f54a52d14 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-12T04:25:00Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-dab0b37b050c4464a0265e9f54a52d142022-12-22T03:48:06ZengBMCBMC Neurology1471-23772018-10-0118111110.1186/s12883-018-1171-8Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trialsTao Xue0Zhouqing Chen1Weiwei Lin2Jiayi Xu3Xuming Shen4Zhong Wang5Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow UniversityDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow UniversityUniversity of Pittsburgh School of PharmacyDepartment of Ophthalmology, The First Affiliated Hospital of Soochow UniversityDepartment of Neurosurgery, Taicang Affiliated Hospital of Soochow UniversityDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow UniversityAbstract Background Recent studies have shown conflicting results regarding the effect of hydrogel coils for treating intracranial aneurysm compared to bare platinum coils. We implemented a meta-analysis to assess the value of hydrogel coils in intracranial aneurysm treatment. Methods The MEDLINE, EMBASE, and Cochrane Library databases were searched for randomized controlled trials (RCTs) which had evaluated hydrogel coils versus bare platinum coils for intracranial aneurysms. Results We pooled 1526 patients from 4 RCTs with the mean follow-up time of more than 16 months. Hydrogel coils had reductions on mid-term recurrence (RR 0.78, 95% CI 0.65 to 0.94, P = 0.008) and residual aneurysm (RR 0.71, 95% CI 0.57 to 0.88, P = 0.002), but didn’t show any significant differences in other favorable outcomes such as functional recovery, mortality and so on. In the subgroup analysis, we found that second-generation hydrogel coils might exhibit potential impacts on increasing mid-term complete occlusion (RR 1.26, 95% CI 1.07 to 1.48, P = 0.005) and decreasing residual aneurysm neck. (RR 0.54, 95% CI 0.34 to 0.86, P = 0.010). Conclusions Hydrogel coils showed no significant efficacy on functional recovery but exhibited a lower rate of recurrences and residual aneurysms in patients with intracranial aneurysms.http://link.springer.com/article/10.1186/s12883-018-1171-8Hydrogel coilsBare platinum coilsEndovascular treatmentIntracranial aneurysmsMeta-analysis |
| spellingShingle | Tao Xue Zhouqing Chen Weiwei Lin Jiayi Xu Xuming Shen Zhong Wang Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trials BMC Neurology Hydrogel coils Bare platinum coils Endovascular treatment Intracranial aneurysms Meta-analysis |
| title | Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trials |
| title_full | Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trials |
| title_fullStr | Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trials |
| title_full_unstemmed | Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trials |
| title_short | Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trials |
| title_sort | hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms a meta analysis of randomized controlled trials |
| topic | Hydrogel coils Bare platinum coils Endovascular treatment Intracranial aneurysms Meta-analysis |
| url | http://link.springer.com/article/10.1186/s12883-018-1171-8 |
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