Discovery of Novel Diarylamide <i>N</i>-Containing Heterocyclic Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity

Discovery of Novel Diarylamide <i>N</i>-Containing Heterocyclic Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity

Tubulin has been regarded as an attractive and successful molecular target in cancer therapy and drug discovery. Vicinal diaryl is a simple scaffold found in many colchicine site tubulin inhibitors, which is also an important pharmacophoric point of tubulin binding and anti-cancer activity. As the c...

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Bibliographic Details
Main Authors: Xu Liu, Xiao-Jing Pang, Yuan Liu, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Yan-Bing Zhang, Jian Song, Sai-Yang Zhang
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
tubulin
CA-4
vicinal diaryl
<i>N</i>-containing heterocyclics
anti-proliferative activity
colchicine binding site
Online Access:https://www.mdpi.com/1420-3049/26/13/4047

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