Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages

Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages

HIV-1 Vpr is necessary for maximal HIV infection and spread in macrophages. Evolutionary conservation of Vpr suggests an important yet poorly understood role for macrophages in HIV pathogenesis. Vpr counteracts a previously unknown macrophage-specific restriction factor that targets and reduces the...

Full description

Bibliographic Details
Main Authors: Jay Lubow, Maria C Virgilio, Madeline Merlino, David R Collins, Michael Mashiba, Brian G Peterson, Zana Lukic, Mark M Painter, Francisco Gomez-Rivera, Valeri Terry, Gretchen Zimmerman, Kathleen L Collins
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
HIV
mannose receptor
Vpr
Nef
restriction factor
macrophages
Online Access:https://elifesciences.org/articles/51035

Similar Items

Similar Items