Haemodynamic and pulse wave responses to intravenous infusions of angiotensin II during chronic telmisartan therapy in normal volunteers
Introduction This study investigated the central haemodynamic, blood pressure (BP) and pulse wave responses to progressively increasing infusion rates of intravenous angiotensin II (Ang II) in normal volunteers during chronic therapy with telmisartan or placebo. Materials and methods Ten normal volu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2003-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.3317/jraas.2003.039 |
| _version_ | 1797283757870284800 |
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| author | Noreen M Vingerhoedt Rozemarie Gilles Jan B Howes Matthew Griffin Laurence Guy Howes |
| author_facet | Noreen M Vingerhoedt Rozemarie Gilles Jan B Howes Matthew Griffin Laurence Guy Howes |
| author_sort | Noreen M Vingerhoedt |
| collection | DOAJ |
| description | Introduction This study investigated the central haemodynamic, blood pressure (BP) and pulse wave responses to progressively increasing infusion rates of intravenous angiotensin II (Ang II) in normal volunteers during chronic therapy with telmisartan or placebo. Materials and methods Ten normal volunteers, aged 21—33 years, completed a ramdomised, double-blind crossover study. Ang II was infused intravenously at increasing infusion rates (0—512 ng/minute) at the end of one week of telmisartan therapy (40—80 mg/day) and one week of placebo therapy. BP, central haemodynamics and pulse wave parameters were monitored continuous using a CardioDynamics Recorder, a Pulse Tracer Recorder and a Finipress Recorder. Results Baseline diastolic BP (5712 v G s. 67±13 mmHg) and pulse wave reflection ndex (RI) (38.4±18.6 vs. 60.6±12.5%) were significantly lower U on telmisartan than on placebo therapy. Cardiac index (CI), systolic BP, systemic vascular resistance index (SVRI), RI and pulse wave stiffness index (SI) were all significantly increased in a dose-dependent manner by Ang II on placebo therapy. Telmisartan significantly (p<0.05) attenuated all of these responses to Ang II. Increases in BP during Ang II infusion were associated with increases in SVRI and CI. Conclusions Telmisartan effectively blocked the effects of intravenous Ang II on CI, BP, RI and SI in healthy volunteers. Changes in CI make a major contribution to increase in BP response to intravenous Ang II in normal volunteers. |
| first_indexed | 2024-03-07T17:36:26Z |
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| id | doaj.art-dab4ca5ae2744e8587a76fb6f8978dbf |
| institution | Directory Open Access Journal |
| issn | 1470-3203 |
| language | English |
| last_indexed | 2024-03-07T17:36:26Z |
| publishDate | 2003-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-dab4ca5ae2744e8587a76fb6f8978dbf2024-03-02T16:49:23ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32032003-12-01410.3317/jraas.2003.039Haemodynamic and pulse wave responses to intravenous infusions of angiotensin II during chronic telmisartan therapy in normal volunteersNoreen M VingerhoedtRozemarie GillesJan B HowesMatthew GriffinLaurence Guy HowesIntroduction This study investigated the central haemodynamic, blood pressure (BP) and pulse wave responses to progressively increasing infusion rates of intravenous angiotensin II (Ang II) in normal volunteers during chronic therapy with telmisartan or placebo. Materials and methods Ten normal volunteers, aged 21—33 years, completed a ramdomised, double-blind crossover study. Ang II was infused intravenously at increasing infusion rates (0—512 ng/minute) at the end of one week of telmisartan therapy (40—80 mg/day) and one week of placebo therapy. BP, central haemodynamics and pulse wave parameters were monitored continuous using a CardioDynamics Recorder, a Pulse Tracer Recorder and a Finipress Recorder. Results Baseline diastolic BP (5712 v G s. 67±13 mmHg) and pulse wave reflection ndex (RI) (38.4±18.6 vs. 60.6±12.5%) were significantly lower U on telmisartan than on placebo therapy. Cardiac index (CI), systolic BP, systemic vascular resistance index (SVRI), RI and pulse wave stiffness index (SI) were all significantly increased in a dose-dependent manner by Ang II on placebo therapy. Telmisartan significantly (p<0.05) attenuated all of these responses to Ang II. Increases in BP during Ang II infusion were associated with increases in SVRI and CI. Conclusions Telmisartan effectively blocked the effects of intravenous Ang II on CI, BP, RI and SI in healthy volunteers. Changes in CI make a major contribution to increase in BP response to intravenous Ang II in normal volunteers.https://doi.org/10.3317/jraas.2003.039 |
| spellingShingle | Noreen M Vingerhoedt Rozemarie Gilles Jan B Howes Matthew Griffin Laurence Guy Howes Haemodynamic and pulse wave responses to intravenous infusions of angiotensin II during chronic telmisartan therapy in normal volunteers Journal of the Renin-Angiotensin-Aldosterone System |
| title | Haemodynamic and pulse wave responses to intravenous infusions of angiotensin II during chronic telmisartan therapy in normal volunteers |
| title_full | Haemodynamic and pulse wave responses to intravenous infusions of angiotensin II during chronic telmisartan therapy in normal volunteers |
| title_fullStr | Haemodynamic and pulse wave responses to intravenous infusions of angiotensin II during chronic telmisartan therapy in normal volunteers |
| title_full_unstemmed | Haemodynamic and pulse wave responses to intravenous infusions of angiotensin II during chronic telmisartan therapy in normal volunteers |
| title_short | Haemodynamic and pulse wave responses to intravenous infusions of angiotensin II during chronic telmisartan therapy in normal volunteers |
| title_sort | haemodynamic and pulse wave responses to intravenous infusions of angiotensin ii during chronic telmisartan therapy in normal volunteers |
| url | https://doi.org/10.3317/jraas.2003.039 |
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