Leishmania braziliensis: partial control of experimental infection by interleukin-12 p40 deficient mice
Resistance to infection by Leishmania major has been associated with the development of a Th1 type response that is dependent on the presence of interleukin 12 (IL-12). In this work the involvement of this cytokine in the response to infection by L. braziliensis, a less virulent species in the mouse...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2004-05-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300009 |
| _version_ | 1797757004044828672 |
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| author | Sebastião Martins de Souza-Neto Cláudia Martins Carneiro Leda Quercia Vieira Luís Carlos Crocco Afonso |
| author_facet | Sebastião Martins de Souza-Neto Cláudia Martins Carneiro Leda Quercia Vieira Luís Carlos Crocco Afonso |
| author_sort | Sebastião Martins de Souza-Neto |
| collection | DOAJ |
| description | Resistance to infection by Leishmania major has been associated with the development of a Th1 type response that is dependent on the presence of interleukin 12 (IL-12). In this work the involvement of this cytokine in the response to infection by L. braziliensis, a less virulent species in the mouse model, was evaluated. Our results show that while interferon (IFN<FONT FACE=Symbol>-g</FONT>) deficient (-/-) mice inoculated L. braziliensis develop severe uncontrolled lesions, chronic lesions that remained under control up to 12 weeks of infection were observed in IL-12p40 -/- mice. IL 12p40 -/- mice had fewer parasites in their lesions than IFN<FONT FACE=Symbol>-g</FONT>-/- mice. Lymph node cells from IL-12p40 -/- were capable of producing low but consistent levels of IFN<FONT FACE=Symbol>-g</FONT> suggestive of its involvement in parasite control. Furthermore, as opposed to previous reports on L. major-infected animals, no switch to a Th2 response was observed in IL-12p40 -/- infected with L. braziliensis. |
| first_indexed | 2024-03-12T18:09:44Z |
| format | Article |
| id | doaj.art-dab5d617a4b24cd0a9e304f6a0d327d2 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:09:44Z |
| publishDate | 2004-05-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-dab5d617a4b24cd0a9e304f6a0d327d22023-08-02T09:16:38ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602004-05-0199328929410.1590/S0074-02762004000300009Leishmania braziliensis: partial control of experimental infection by interleukin-12 p40 deficient miceSebastião Martins de Souza-NetoCláudia Martins CarneiroLeda Quercia VieiraLuís Carlos Crocco AfonsoResistance to infection by Leishmania major has been associated with the development of a Th1 type response that is dependent on the presence of interleukin 12 (IL-12). In this work the involvement of this cytokine in the response to infection by L. braziliensis, a less virulent species in the mouse model, was evaluated. Our results show that while interferon (IFN<FONT FACE=Symbol>-g</FONT>) deficient (-/-) mice inoculated L. braziliensis develop severe uncontrolled lesions, chronic lesions that remained under control up to 12 weeks of infection were observed in IL-12p40 -/- mice. IL 12p40 -/- mice had fewer parasites in their lesions than IFN<FONT FACE=Symbol>-g</FONT>-/- mice. Lymph node cells from IL-12p40 -/- were capable of producing low but consistent levels of IFN<FONT FACE=Symbol>-g</FONT> suggestive of its involvement in parasite control. Furthermore, as opposed to previous reports on L. major-infected animals, no switch to a Th2 response was observed in IL-12p40 -/- infected with L. braziliensis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300009cutaneous leishmaniasisLeishmania braziliensisinterleukin 12 |
| spellingShingle | Sebastião Martins de Souza-Neto Cláudia Martins Carneiro Leda Quercia Vieira Luís Carlos Crocco Afonso Leishmania braziliensis: partial control of experimental infection by interleukin-12 p40 deficient mice Memorias do Instituto Oswaldo Cruz cutaneous leishmaniasis Leishmania braziliensis interleukin 12 |
| title | Leishmania braziliensis: partial control of experimental infection by interleukin-12 p40 deficient mice |
| title_full | Leishmania braziliensis: partial control of experimental infection by interleukin-12 p40 deficient mice |
| title_fullStr | Leishmania braziliensis: partial control of experimental infection by interleukin-12 p40 deficient mice |
| title_full_unstemmed | Leishmania braziliensis: partial control of experimental infection by interleukin-12 p40 deficient mice |
| title_short | Leishmania braziliensis: partial control of experimental infection by interleukin-12 p40 deficient mice |
| title_sort | leishmania braziliensis partial control of experimental infection by interleukin 12 p40 deficient mice |
| topic | cutaneous leishmaniasis Leishmania braziliensis interleukin 12 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300009 |
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