The clinical application of longitudinal layer specific strain as a diagnostic and prognostic instrument in ischemic heart diseases: A systematic review and meta-analysis
Background2-dimensional Speckle-Tracking Echocardiography, to obtain longitudinal layer specific strain (LSS), has recently emerged as a novel and accurate non-invasive imaging technique for diagnosis as well as for prediction of adverse cardiac events. This systematic review and meta-analysis aimed...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.980626/full |
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| author | Shreeya Sharma Mats Christian Højbjerg Lassen Mats Christian Højbjerg Lassen Mats Christian Højbjerg Lassen Anne Bjerg Nielsen Kristoffer Grundtvig Skaarup Kristoffer Grundtvig Skaarup Kristoffer Grundtvig Skaarup Tor Biering-Sørensen Tor Biering-Sørensen Tor Biering-Sørensen |
| author_facet | Shreeya Sharma Mats Christian Højbjerg Lassen Mats Christian Højbjerg Lassen Mats Christian Højbjerg Lassen Anne Bjerg Nielsen Kristoffer Grundtvig Skaarup Kristoffer Grundtvig Skaarup Kristoffer Grundtvig Skaarup Tor Biering-Sørensen Tor Biering-Sørensen Tor Biering-Sørensen |
| author_sort | Shreeya Sharma |
| collection | DOAJ |
| description | Background2-dimensional Speckle-Tracking Echocardiography, to obtain longitudinal layer specific strain (LSS), has recently emerged as a novel and accurate non-invasive imaging technique for diagnosis as well as for prediction of adverse cardiac events. This systematic review and meta-analysis aimed to give an overview of the possible clinical implication and significance of longitudinal LSS.MethodsWe conducted a systematic review and meta-analysis with all the studies involving layer specific strain in patients with ischemic heart disease (IHD). Of 40 eligible studies, 9 met our inclusion criteria. Studies that were included either investigated the prognostic value (n = 3) or the diagnostic value (n = 6) of longitudinal LSS.ResultsThe pooled meta-analysis showed that longitudinal LSS is a significant diagnostic marker for coronary artery disease (CAD) in patients with IHD. Endocardial LSS was found to be a good diagnostic marker for CAD in IHD patients (OR: 1.28, CI95% [1.11–1.48], p < 0.001, per 1% decrease). Epicardial (OR: 1.34, CI95% [1.14–1.56], p < 0.001, per 1% decrease), Mid-Myocardial (OR: 1.24, CI95% [1.12–1.38], p < 0.001, per 1% decrease) and endocardial (OR: 1.21, CI95% [1.09–1.35], p < 0.001, per 1% decrease) LSS all entailed diagnostic information regarding CAD, with epicardial LSS emerging as the superior diagnostic marker for CAD in patients with SAP. Endocardial LSS proved to be the better diagnostic marker of CAD in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). LSS was shown to be a good prognostic maker of adverse cardiac events in IHD patients. Two studies found endocardial circumferential strain to be the good predictor of outcome in CAD patients and when added to baseline characteristics. Epicardial LSS emerged as best predictor in acute coronary syndrome (ACS) patients.ConclusionIn patients with SAP, epicardial LSS was the stronger diagnostic marker while in NSTE-ACS patients, endocardial LSS was the stronger diagnostic marker. In addition, endocardial circumferential strain is the better predictor of adverse outcome in CAD patients whilst in ACS patients, epicardial LSS was found to be a better predictor of outcome. |
| first_indexed | 2024-04-09T21:34:10Z |
| format | Article |
| id | doaj.art-dab6fe8ea6c94dc8aeed3d1378603f75 |
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| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-09T21:34:10Z |
| publishDate | 2023-03-01 |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-dab6fe8ea6c94dc8aeed3d1378603f752023-03-27T05:18:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-03-011010.3389/fcvm.2023.980626980626The clinical application of longitudinal layer specific strain as a diagnostic and prognostic instrument in ischemic heart diseases: A systematic review and meta-analysisShreeya Sharma0Mats Christian Højbjerg Lassen1Mats Christian Højbjerg Lassen2Mats Christian Højbjerg Lassen3Anne Bjerg Nielsen4Kristoffer Grundtvig Skaarup5Kristoffer Grundtvig Skaarup6Kristoffer Grundtvig Skaarup7Tor Biering-Sørensen8Tor Biering-Sørensen9Tor Biering-Sørensen10Department of Cardiology, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, DenmarkCenter for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkThe Copenhagen City Heart Study, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, DenmarkCenter for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkThe Copenhagen City Heart Study, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, DenmarkCenter for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkThe Copenhagen City Heart Study, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, DenmarkBackground2-dimensional Speckle-Tracking Echocardiography, to obtain longitudinal layer specific strain (LSS), has recently emerged as a novel and accurate non-invasive imaging technique for diagnosis as well as for prediction of adverse cardiac events. This systematic review and meta-analysis aimed to give an overview of the possible clinical implication and significance of longitudinal LSS.MethodsWe conducted a systematic review and meta-analysis with all the studies involving layer specific strain in patients with ischemic heart disease (IHD). Of 40 eligible studies, 9 met our inclusion criteria. Studies that were included either investigated the prognostic value (n = 3) or the diagnostic value (n = 6) of longitudinal LSS.ResultsThe pooled meta-analysis showed that longitudinal LSS is a significant diagnostic marker for coronary artery disease (CAD) in patients with IHD. Endocardial LSS was found to be a good diagnostic marker for CAD in IHD patients (OR: 1.28, CI95% [1.11–1.48], p < 0.001, per 1% decrease). Epicardial (OR: 1.34, CI95% [1.14–1.56], p < 0.001, per 1% decrease), Mid-Myocardial (OR: 1.24, CI95% [1.12–1.38], p < 0.001, per 1% decrease) and endocardial (OR: 1.21, CI95% [1.09–1.35], p < 0.001, per 1% decrease) LSS all entailed diagnostic information regarding CAD, with epicardial LSS emerging as the superior diagnostic marker for CAD in patients with SAP. Endocardial LSS proved to be the better diagnostic marker of CAD in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). LSS was shown to be a good prognostic maker of adverse cardiac events in IHD patients. Two studies found endocardial circumferential strain to be the good predictor of outcome in CAD patients and when added to baseline characteristics. Epicardial LSS emerged as best predictor in acute coronary syndrome (ACS) patients.ConclusionIn patients with SAP, epicardial LSS was the stronger diagnostic marker while in NSTE-ACS patients, endocardial LSS was the stronger diagnostic marker. In addition, endocardial circumferential strain is the better predictor of adverse outcome in CAD patients whilst in ACS patients, epicardial LSS was found to be a better predictor of outcome.https://www.frontiersin.org/articles/10.3389/fcvm.2023.980626/fulllongitudinal layer specific strainischemic heart diseasecoronary artery diseaseacute coronary syndome2 dimensional speckle tracking echocardiography |
| spellingShingle | Shreeya Sharma Mats Christian Højbjerg Lassen Mats Christian Højbjerg Lassen Mats Christian Højbjerg Lassen Anne Bjerg Nielsen Kristoffer Grundtvig Skaarup Kristoffer Grundtvig Skaarup Kristoffer Grundtvig Skaarup Tor Biering-Sørensen Tor Biering-Sørensen Tor Biering-Sørensen The clinical application of longitudinal layer specific strain as a diagnostic and prognostic instrument in ischemic heart diseases: A systematic review and meta-analysis Frontiers in Cardiovascular Medicine longitudinal layer specific strain ischemic heart disease coronary artery disease acute coronary syndome 2 dimensional speckle tracking echocardiography |
| title | The clinical application of longitudinal layer specific strain as a diagnostic and prognostic instrument in ischemic heart diseases: A systematic review and meta-analysis |
| title_full | The clinical application of longitudinal layer specific strain as a diagnostic and prognostic instrument in ischemic heart diseases: A systematic review and meta-analysis |
| title_fullStr | The clinical application of longitudinal layer specific strain as a diagnostic and prognostic instrument in ischemic heart diseases: A systematic review and meta-analysis |
| title_full_unstemmed | The clinical application of longitudinal layer specific strain as a diagnostic and prognostic instrument in ischemic heart diseases: A systematic review and meta-analysis |
| title_short | The clinical application of longitudinal layer specific strain as a diagnostic and prognostic instrument in ischemic heart diseases: A systematic review and meta-analysis |
| title_sort | clinical application of longitudinal layer specific strain as a diagnostic and prognostic instrument in ischemic heart diseases a systematic review and meta analysis |
| topic | longitudinal layer specific strain ischemic heart disease coronary artery disease acute coronary syndome 2 dimensional speckle tracking echocardiography |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.980626/full |
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