Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation

Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation

Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role. Murine studies showed that CYP1B1 enhances, while CYP1A1 and CYP1A2 protect fr...

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Bibliographic Details
Main Authors: Sandra L. Grimm, Rachel E. Stading, Matthew J. Robertson, Tanmay Gandhi, Chenlian Fu, Weiwu Jiang, Guobin Xia, Krithika Lingappan, Cristian Coarfa, Bhagavatula Moorthy
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Redox Biology
Subjects:
Hyperoxia
Cytochrome P450
CYP1B1
Bronchopulmonary dysplasia
Lung
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172300191X

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http://www.sciencedirect.com/science/article/pii/S221323172300191X

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