Context-dependent functions of specific microRNAs in neuronal development
<p>Abstract</p> <p>MicroRNAs (miRNAs) are small noncoding RNAs that regulate multiple developmental processes at the post-transcriptional level. Recent rapid progresses have demonstrated critical roles for a number of miRNAs in neuronal development and function. In particular, miR-...
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| Format: | Article |
| Language: | English |
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BMC
2010-10-01
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| Series: | Neural Development |
| Online Access: | http://www.neuraldevelopment.com/content/5/1/25 |
| _version_ | 1818835849455861760 |
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| author | Gao Fen-Biao |
| author_facet | Gao Fen-Biao |
| author_sort | Gao Fen-Biao |
| collection | DOAJ |
| description | <p>Abstract</p> <p>MicroRNAs (miRNAs) are small noncoding RNAs that regulate multiple developmental processes at the post-transcriptional level. Recent rapid progresses have demonstrated critical roles for a number of miRNAs in neuronal development and function. In particular, miR-9 and miR-124 are specifically expressed in the mammalian nervous system, and their respective nucleotide sequences are 100% identical among many species. Yet, their expression patterns and mRNA targets are less conserved throughout evolution. As a consequence, these miRNAs exhibit diverse context-dependent functions in different aspects of neuronal development, ranging from early neurogenesis and neuronal differentiation to dendritic morphogenesis and synaptic plasticity. Some other neuronal miRNAs also exhibit context-dependent functions in development. Thus, post-transcriptional regulation of spatial and temporal expression levels of protein-coding genes by miRNAs contributes uniquely to the proper development and evolution of the complex nervous system.</p> |
| first_indexed | 2024-12-19T02:57:15Z |
| format | Article |
| id | doaj.art-daba06f0f71a42419fb4f1142e45e3e8 |
| institution | Directory Open Access Journal |
| issn | 1749-8104 |
| language | English |
| last_indexed | 2024-12-19T02:57:15Z |
| publishDate | 2010-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Neural Development |
| spelling | doaj.art-daba06f0f71a42419fb4f1142e45e3e82022-12-21T20:38:19ZengBMCNeural Development1749-81042010-10-01512510.1186/1749-8104-5-25Context-dependent functions of specific microRNAs in neuronal developmentGao Fen-Biao<p>Abstract</p> <p>MicroRNAs (miRNAs) are small noncoding RNAs that regulate multiple developmental processes at the post-transcriptional level. Recent rapid progresses have demonstrated critical roles for a number of miRNAs in neuronal development and function. In particular, miR-9 and miR-124 are specifically expressed in the mammalian nervous system, and their respective nucleotide sequences are 100% identical among many species. Yet, their expression patterns and mRNA targets are less conserved throughout evolution. As a consequence, these miRNAs exhibit diverse context-dependent functions in different aspects of neuronal development, ranging from early neurogenesis and neuronal differentiation to dendritic morphogenesis and synaptic plasticity. Some other neuronal miRNAs also exhibit context-dependent functions in development. Thus, post-transcriptional regulation of spatial and temporal expression levels of protein-coding genes by miRNAs contributes uniquely to the proper development and evolution of the complex nervous system.</p>http://www.neuraldevelopment.com/content/5/1/25 |
| spellingShingle | Gao Fen-Biao Context-dependent functions of specific microRNAs in neuronal development Neural Development |
| title | Context-dependent functions of specific microRNAs in neuronal development |
| title_full | Context-dependent functions of specific microRNAs in neuronal development |
| title_fullStr | Context-dependent functions of specific microRNAs in neuronal development |
| title_full_unstemmed | Context-dependent functions of specific microRNAs in neuronal development |
| title_short | Context-dependent functions of specific microRNAs in neuronal development |
| title_sort | context dependent functions of specific micrornas in neuronal development |
| url | http://www.neuraldevelopment.com/content/5/1/25 |
| work_keys_str_mv | AT gaofenbiao contextdependentfunctionsofspecificmicrornasinneuronaldevelopment |