QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch Model
Rocaglamide derivatives are the compounds which have featuring cyclopenta[b]tetra-hydrobenzofuran skeleton. Until now it includes more than 50 naturally occurring derivatives. They were chosen to be interesting candidates for possible therapeutic agents primarily in the field of cancer chemotherapy...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Indonesian Society for Cancer Chemoprevention
2010-06-01
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| Series: | ISCC (Indonesian Journal of Cancer Chemoprevention) |
| Online Access: | https://ijcc.chemoprev.org/index.php/ijcc/article/view/21 |
| _version_ | 1828199143977254912 |
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| author | Firdayani Firdayani Susi Kusumaningrum Doddy Irawan Setyo Utomo Agung Eru Wibowo Chaidir Chaidir |
| author_facet | Firdayani Firdayani Susi Kusumaningrum Doddy Irawan Setyo Utomo Agung Eru Wibowo Chaidir Chaidir |
| author_sort | Firdayani Firdayani |
| collection | DOAJ |
| description | Rocaglamide derivatives are the compounds which have featuring cyclopenta[b]tetra-hydrobenzofuran skeleton. Until now it includes more than 50 naturally occurring derivatives. They were chosen to be interesting candidates for possible therapeutic agents primarily in the field of cancer chemotherapy due to their cytotoxic activities data against various cancer cells. A quantitative structure activity relationship (QSAR) studies were done to investigate physicochemical properties of molecule which contribute to their activities. Series of rocaglamide derivatives have been used and analyzed using linear free energy regression Hansch model for their cytotoxic activities against MONO-MAC-6 leukemia cells, RAJI lymphoma cells and MEL-JUSO melanoma cells. Results showed that the best QSAR equations were revealed involving C Log P and CMR parameters with nonlinear regression relationships in cytotoxic activities of rocaglamide derivatives against cancer cells above.
Keywords: QSAR, Rocaglamide, LFER Hansch |
| first_indexed | 2024-04-12T10:50:23Z |
| format | Article |
| id | doaj.art-dabb83e2cac04103bd5f46224cbcd098 |
| institution | Directory Open Access Journal |
| issn | 2088-0197 2355-8989 |
| language | English |
| last_indexed | 2024-04-12T10:50:23Z |
| publishDate | 2010-06-01 |
| publisher | Indonesian Society for Cancer Chemoprevention |
| record_format | Article |
| series | ISCC (Indonesian Journal of Cancer Chemoprevention) |
| spelling | doaj.art-dabb83e2cac04103bd5f46224cbcd0982022-12-22T03:36:16ZengIndonesian Society for Cancer ChemopreventionISCC (Indonesian Journal of Cancer Chemoprevention)2088-01972355-89892010-06-011212913410.14499/indonesianjcanchemoprev1iss2pp129-13422QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch ModelFirdayani Firdayani0Susi Kusumaningrum1Doddy Irawan Setyo Utomo2Agung Eru Wibowo3Chaidir Chaidir4Center of Pharmaceutical and Medical Technology Agency on Assessment and Application of Technology (BPPT)Center of Pharmaceutical and Medical Technology Agency on Assessment and Application of Technology (BPPT)Center of Pharmaceutical and Medical Technology Agency on Assessment and Application of Technology (BPPT)Center of Pharmaceutical and Medical Technology Agency on Assessment and Application of Technology (BPPT)Center of Pharmaceutical and Medical Technology Agency on Assessment and Application of Technology (BPPT)Rocaglamide derivatives are the compounds which have featuring cyclopenta[b]tetra-hydrobenzofuran skeleton. Until now it includes more than 50 naturally occurring derivatives. They were chosen to be interesting candidates for possible therapeutic agents primarily in the field of cancer chemotherapy due to their cytotoxic activities data against various cancer cells. A quantitative structure activity relationship (QSAR) studies were done to investigate physicochemical properties of molecule which contribute to their activities. Series of rocaglamide derivatives have been used and analyzed using linear free energy regression Hansch model for their cytotoxic activities against MONO-MAC-6 leukemia cells, RAJI lymphoma cells and MEL-JUSO melanoma cells. Results showed that the best QSAR equations were revealed involving C Log P and CMR parameters with nonlinear regression relationships in cytotoxic activities of rocaglamide derivatives against cancer cells above. Keywords: QSAR, Rocaglamide, LFER Hanschhttps://ijcc.chemoprev.org/index.php/ijcc/article/view/21 |
| spellingShingle | Firdayani Firdayani Susi Kusumaningrum Doddy Irawan Setyo Utomo Agung Eru Wibowo Chaidir Chaidir QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch Model ISCC (Indonesian Journal of Cancer Chemoprevention) |
| title | QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch Model |
| title_full | QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch Model |
| title_fullStr | QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch Model |
| title_full_unstemmed | QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch Model |
| title_short | QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch Model |
| title_sort | qsar analysis of rocaglamide derivatives cytotoxic activities using lfer hansch model |
| url | https://ijcc.chemoprev.org/index.php/ijcc/article/view/21 |
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