PE and PET oligomers’ interplay with membrane bilayers
Abstract The prevalence of microplastic pollution in nature and foodstuffs is fairly well identified. However, studies of micro- or nanoplastics’ cell membrane permeation and health effects in humans are lacking. Our study focuses on examining the interactions of polyethylene (PE) and polyethylene t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-06217-4 |
| _version_ | 1818330560613842944 |
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| author | Joni Järvenpää Milla Perkkiö Riikka Laitinen Maija Lahtela-Kakkonen |
| author_facet | Joni Järvenpää Milla Perkkiö Riikka Laitinen Maija Lahtela-Kakkonen |
| author_sort | Joni Järvenpää |
| collection | DOAJ |
| description | Abstract The prevalence of microplastic pollution in nature and foodstuffs is fairly well identified. However, studies of micro- or nanoplastics’ cell membrane permeation and health effects in humans are lacking. Our study focuses on examining the interactions of polyethylene (PE) and polyethylene terephthalate (PET) with bilayer membranes. We have performed molecular dynamics simulations to study how plastic oligomers behave in bilayers. In addition, we have studied membrane permeation of PE and Bis(2-hydroxyethyl) terephthalate (BHET), a type of PET monomer, with Parallel Artificial Membrane Permeability Assay (PAMPA). As a result, in simulations the molecules exhibited different movements and preferred locations in membrane. PAMPA studies suggested similar preferences in membrane, especially for PE plastic. Our results suggest that passive diffusion could be an important transport mechanism into cells for some small plastic oligomers. Both molecular dynamics simulations and PAMPA have potential for micro- and nanoplastics research. |
| first_indexed | 2024-12-13T13:05:54Z |
| format | Article |
| id | doaj.art-dabd257d3e3542ac882a31f85e1d92f1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T13:05:54Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-dabd257d3e3542ac882a31f85e1d92f12022-12-21T23:44:50ZengNature PortfolioScientific Reports2045-23222022-02-011211810.1038/s41598-022-06217-4PE and PET oligomers’ interplay with membrane bilayersJoni Järvenpää0Milla Perkkiö1Riikka Laitinen2Maija Lahtela-Kakkonen3School of Pharmacy, Faculty of Health Sciences, University of Eastern FinlandSchool of Pharmacy, Faculty of Health Sciences, University of Eastern FinlandSchool of Pharmacy, Faculty of Health Sciences, University of Eastern FinlandSchool of Pharmacy, Faculty of Health Sciences, University of Eastern FinlandAbstract The prevalence of microplastic pollution in nature and foodstuffs is fairly well identified. However, studies of micro- or nanoplastics’ cell membrane permeation and health effects in humans are lacking. Our study focuses on examining the interactions of polyethylene (PE) and polyethylene terephthalate (PET) with bilayer membranes. We have performed molecular dynamics simulations to study how plastic oligomers behave in bilayers. In addition, we have studied membrane permeation of PE and Bis(2-hydroxyethyl) terephthalate (BHET), a type of PET monomer, with Parallel Artificial Membrane Permeability Assay (PAMPA). As a result, in simulations the molecules exhibited different movements and preferred locations in membrane. PAMPA studies suggested similar preferences in membrane, especially for PE plastic. Our results suggest that passive diffusion could be an important transport mechanism into cells for some small plastic oligomers. Both molecular dynamics simulations and PAMPA have potential for micro- and nanoplastics research.https://doi.org/10.1038/s41598-022-06217-4 |
| spellingShingle | Joni Järvenpää Milla Perkkiö Riikka Laitinen Maija Lahtela-Kakkonen PE and PET oligomers’ interplay with membrane bilayers Scientific Reports |
| title | PE and PET oligomers’ interplay with membrane bilayers |
| title_full | PE and PET oligomers’ interplay with membrane bilayers |
| title_fullStr | PE and PET oligomers’ interplay with membrane bilayers |
| title_full_unstemmed | PE and PET oligomers’ interplay with membrane bilayers |
| title_short | PE and PET oligomers’ interplay with membrane bilayers |
| title_sort | pe and pet oligomers interplay with membrane bilayers |
| url | https://doi.org/10.1038/s41598-022-06217-4 |
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