IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB
IMGT®, the international ImMunoGeneTics information system® is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT® marked the advent of immunoinformatics, which emerged at the interface between immun...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00821/full |
| _version_ | 1818528735731646464 |
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| author | Perrine Pégorier Morgane Bertignac Imène Chentli Viviane Nguefack Ngoune Géraldine Folch Joumana Jabado-Michaloud Saida Hadi-Saljoqi Véronique Giudicelli Patrice Duroux Marie-Paule Lefranc Sofia Kossida |
| author_facet | Perrine Pégorier Morgane Bertignac Imène Chentli Viviane Nguefack Ngoune Géraldine Folch Joumana Jabado-Michaloud Saida Hadi-Saljoqi Véronique Giudicelli Patrice Duroux Marie-Paule Lefranc Sofia Kossida |
| author_sort | Perrine Pégorier |
| collection | DOAJ |
| description | IMGT®, the international ImMunoGeneTics information system® is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and proteins of the IgSF and MhSF superfamilies. T cell receptors are divided into two groups, αβ and γδ TR, which express distinct TR containing either α and β, or γ and δ chains, respectively. The TRβ locus (TRB) was recently described and annotated by IMGT® biocurators for several veterinary species, i.e., cat (Felis catus), dog (Canis lupus familiaris), ferret (Mustela putorius furo), pig (Sus scrofa), rabbit (Oryctolagus cuniculus), rhesus monkey (Macaca mulatta), and sheep (Ovis aries). The aim of the present study is to compare the genes of the TRB locus among these different veterinary species based on Homo sapiens. The results reveal that there are similarities but also differences including the number of genes by subgroup which may demonstrate duplications and/or deletions during evolution. |
| first_indexed | 2024-12-11T06:53:52Z |
| format | Article |
| id | doaj.art-dac102ad096e4837b9e2614e61f4fe1b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T06:53:52Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dac102ad096e4837b9e2614e61f4fe1b2022-12-22T01:16:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-05-011110.3389/fimmu.2020.00821529255IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRBPerrine PégorierMorgane BertignacImène ChentliViviane Nguefack NgouneGéraldine FolchJoumana Jabado-MichaloudSaida Hadi-SaljoqiVéronique GiudicelliPatrice DurouxMarie-Paule LefrancSofia KossidaIMGT®, the international ImMunoGeneTics information system® is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and proteins of the IgSF and MhSF superfamilies. T cell receptors are divided into two groups, αβ and γδ TR, which express distinct TR containing either α and β, or γ and δ chains, respectively. The TRβ locus (TRB) was recently described and annotated by IMGT® biocurators for several veterinary species, i.e., cat (Felis catus), dog (Canis lupus familiaris), ferret (Mustela putorius furo), pig (Sus scrofa), rabbit (Oryctolagus cuniculus), rhesus monkey (Macaca mulatta), and sheep (Ovis aries). The aim of the present study is to compare the genes of the TRB locus among these different veterinary species based on Homo sapiens. The results reveal that there are similarities but also differences including the number of genes by subgroup which may demonstrate duplications and/or deletions during evolution.https://www.frontiersin.org/article/10.3389/fimmu.2020.00821/fullIMGTimmunoinformaticsimmunogeneticsT cell receptorTRB locus |
| spellingShingle | Perrine Pégorier Morgane Bertignac Imène Chentli Viviane Nguefack Ngoune Géraldine Folch Joumana Jabado-Michaloud Saida Hadi-Saljoqi Véronique Giudicelli Patrice Duroux Marie-Paule Lefranc Sofia Kossida IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB Frontiers in Immunology IMGT immunoinformatics immunogenetics T cell receptor TRB locus |
| title | IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB |
| title_full | IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB |
| title_fullStr | IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB |
| title_full_unstemmed | IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB |
| title_short | IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB |
| title_sort | imgt r biocuration and comparative study of the t cell receptor beta locus of veterinary species based on homo sapiens trb |
| topic | IMGT immunoinformatics immunogenetics T cell receptor TRB locus |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00821/full |
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