"PERSISTENCE OF ANTI-HBs ANTIBODIES IN HEALTHY IRANIAN CHILDREN VACCINATED WITH RECOMBINANT HEPATITIS B VACCINE AND RESPONSE TO A BOOSTER DOSE"
Long-term protection against hepatitis B virus (HBV) is dependent on persistence of anti-HBs antibodies and/or strong immunological memory. In this study we evaluated the persistence of anti-HBs antibodies in healthy Iranian children 5 years after primary vaccination and the response to a booster do...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2005-04-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/2968 |
| _version_ | 1819089637688213504 |
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| author | A. Jafarzadeh S. M. A. Sajjadi |
| author_facet | A. Jafarzadeh S. M. A. Sajjadi |
| author_sort | A. Jafarzadeh |
| collection | DOAJ |
| description | Long-term protection against hepatitis B virus (HBV) is dependent on persistence of anti-HBs antibodies and/or strong immunological memory. In this study we evaluated the persistence of anti-HBs antibodies in healthy Iranian children 5 years after primary vaccination and the response to a booster dose using recombinant hepatitis B vaccine. Totally, 81 children who had received primary course of hepatitis B vaccine at 0, 1.5 and 9 months of age were included in this study. A booster dose of hepatitis B vaccine was administered at 5 years after completion of primary vaccination program.
Children were tested for anti-HBs antibody just before administration of booster dose and at 4 weeks after booster vaccination. An 81.5% seroprotection rate (anti-HBs > 10 IU/L) was observed 5 years after primary vaccination. After administration of booster dose, 100% of the children developed protective level of anti-HBs antibody and geometric mean titer rose from 206 IU/L to 1278 IU/L. These results indicate the existence of an effective immunological memory over a period of 5 years after primary vaccination with recombinant hepatitis B vaccine in healthy Iranian children. |
| first_indexed | 2024-12-21T22:11:06Z |
| format | Article |
| id | doaj.art-dac97c6e39e54f06805c29f5f0dcd39c |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-21T22:11:06Z |
| publishDate | 2005-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-dac97c6e39e54f06805c29f5f0dcd39c2022-12-21T18:48:36ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942005-04-01432"PERSISTENCE OF ANTI-HBs ANTIBODIES IN HEALTHY IRANIAN CHILDREN VACCINATED WITH RECOMBINANT HEPATITIS B VACCINE AND RESPONSE TO A BOOSTER DOSE" A. Jafarzadeh0 S. M. A. Sajjadi1 Long-term protection against hepatitis B virus (HBV) is dependent on persistence of anti-HBs antibodies and/or strong immunological memory. In this study we evaluated the persistence of anti-HBs antibodies in healthy Iranian children 5 years after primary vaccination and the response to a booster dose using recombinant hepatitis B vaccine. Totally, 81 children who had received primary course of hepatitis B vaccine at 0, 1.5 and 9 months of age were included in this study. A booster dose of hepatitis B vaccine was administered at 5 years after completion of primary vaccination program. Children were tested for anti-HBs antibody just before administration of booster dose and at 4 weeks after booster vaccination. An 81.5% seroprotection rate (anti-HBs > 10 IU/L) was observed 5 years after primary vaccination. After administration of booster dose, 100% of the children developed protective level of anti-HBs antibody and geometric mean titer rose from 206 IU/L to 1278 IU/L. These results indicate the existence of an effective immunological memory over a period of 5 years after primary vaccination with recombinant hepatitis B vaccine in healthy Iranian children.https://acta.tums.ac.ir/index.php/acta/article/view/2968hepatitis B vaccineanti-HBs antibodiesbooster vaccination |
| spellingShingle | A. Jafarzadeh S. M. A. Sajjadi "PERSISTENCE OF ANTI-HBs ANTIBODIES IN HEALTHY IRANIAN CHILDREN VACCINATED WITH RECOMBINANT HEPATITIS B VACCINE AND RESPONSE TO A BOOSTER DOSE" Acta Medica Iranica hepatitis B vaccine anti-HBs antibodies booster vaccination |
| title | "PERSISTENCE OF ANTI-HBs ANTIBODIES IN HEALTHY IRANIAN CHILDREN VACCINATED WITH RECOMBINANT HEPATITIS B VACCINE AND RESPONSE TO A BOOSTER DOSE" |
| title_full | "PERSISTENCE OF ANTI-HBs ANTIBODIES IN HEALTHY IRANIAN CHILDREN VACCINATED WITH RECOMBINANT HEPATITIS B VACCINE AND RESPONSE TO A BOOSTER DOSE" |
| title_fullStr | "PERSISTENCE OF ANTI-HBs ANTIBODIES IN HEALTHY IRANIAN CHILDREN VACCINATED WITH RECOMBINANT HEPATITIS B VACCINE AND RESPONSE TO A BOOSTER DOSE" |
| title_full_unstemmed | "PERSISTENCE OF ANTI-HBs ANTIBODIES IN HEALTHY IRANIAN CHILDREN VACCINATED WITH RECOMBINANT HEPATITIS B VACCINE AND RESPONSE TO A BOOSTER DOSE" |
| title_short | "PERSISTENCE OF ANTI-HBs ANTIBODIES IN HEALTHY IRANIAN CHILDREN VACCINATED WITH RECOMBINANT HEPATITIS B VACCINE AND RESPONSE TO A BOOSTER DOSE" |
| title_sort | persistence of anti hbs antibodies in healthy iranian children vaccinated with recombinant hepatitis b vaccine and response to a booster dose |
| topic | hepatitis B vaccine anti-HBs antibodies booster vaccination |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/2968 |
| work_keys_str_mv | AT ajafarzadeh persistenceofantihbsantibodiesinhealthyiranianchildrenvaccinatedwithrecombinanthepatitisbvaccineandresponsetoaboosterdose AT smasajjadi persistenceofantihbsantibodiesinhealthyiranianchildrenvaccinatedwithrecombinanthepatitisbvaccineandresponsetoaboosterdose |