Moyamoya Disease: Treatment and Outcomes
Although the pathogenesis of moyamoya disease (MMD) has not been fully elucidated, the effectiveness of surgical revascularization in preventing stroke has been addressed by many studies. The main mechanism of surgical revascularization is augmenting the intracranial blood flow using an external car...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Stroke Society
2016-01-01
|
| Series: | Journal of Stroke |
| Subjects: | |
| Online Access: | http://www.j-stroke.org/upload/pdf/jos-2015-01739.pdf |
| _version_ | 1818217762855583744 |
|---|---|
| author | Tackeun Kim Chang Wan Oh Jae Seung Bang Jeong Eun Kim Won-Sang Cho |
| author_facet | Tackeun Kim Chang Wan Oh Jae Seung Bang Jeong Eun Kim Won-Sang Cho |
| author_sort | Tackeun Kim |
| collection | DOAJ |
| description | Although the pathogenesis of moyamoya disease (MMD) has not been fully elucidated, the effectiveness of surgical revascularization in preventing stroke has been addressed by many studies. The main mechanism of surgical revascularization is augmenting the intracranial blood flow using an external carotid system by either direct bypass or pial synangiosis. This can improve resting cerebral blood flow as well as vascular reserve capacity. For direct revascularization, the superficial temporal artery is used as the donor artery in most cases, although the occipital artery may be used in limited cases. Usually, the cortical branch of the middle cerebral artery is selected as the recipient of direct anastomosis. As for indirect revascularization, various techniques using different kinds of connective tissues have been introduced. In some cases, reinforcing the anterior cerebral artery and the posterior cerebral artery territories can be considered. The effectiveness of surgical revascularization for preventing ischemic stroke had been generally accepted by many studies. However, for preventing hemorrhagic stroke, new evidence has been added by a recent randomized controlled trial. The incidence of peri-operative complications such as stroke and hyperperfusion syndrome seems to be high due to the nature of the disease and technical demands for treatment. Preventing and adequately managing these complications are essential for ensuring the benefits of surgery. |
| first_indexed | 2024-12-12T07:13:02Z |
| format | Article |
| id | doaj.art-dac9f697a1044f168836b51abee16c9f |
| institution | Directory Open Access Journal |
| issn | 2287-6391 2287-6405 |
| language | English |
| last_indexed | 2024-12-12T07:13:02Z |
| publishDate | 2016-01-01 |
| publisher | Korean Stroke Society |
| record_format | Article |
| series | Journal of Stroke |
| spelling | doaj.art-dac9f697a1044f168836b51abee16c9f2022-12-22T00:33:35ZengKorean Stroke SocietyJournal of Stroke2287-63912287-64052016-01-01181213010.5853/jos.2015.01739115Moyamoya Disease: Treatment and OutcomesTackeun Kim0Chang Wan Oh1Jae Seung Bang2Jeong Eun Kim3Won-Sang Cho4 Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea Department of Neurosurgery, Seoul National University College of Medicine, Seoul, KoreaAlthough the pathogenesis of moyamoya disease (MMD) has not been fully elucidated, the effectiveness of surgical revascularization in preventing stroke has been addressed by many studies. The main mechanism of surgical revascularization is augmenting the intracranial blood flow using an external carotid system by either direct bypass or pial synangiosis. This can improve resting cerebral blood flow as well as vascular reserve capacity. For direct revascularization, the superficial temporal artery is used as the donor artery in most cases, although the occipital artery may be used in limited cases. Usually, the cortical branch of the middle cerebral artery is selected as the recipient of direct anastomosis. As for indirect revascularization, various techniques using different kinds of connective tissues have been introduced. In some cases, reinforcing the anterior cerebral artery and the posterior cerebral artery territories can be considered. The effectiveness of surgical revascularization for preventing ischemic stroke had been generally accepted by many studies. However, for preventing hemorrhagic stroke, new evidence has been added by a recent randomized controlled trial. The incidence of peri-operative complications such as stroke and hyperperfusion syndrome seems to be high due to the nature of the disease and technical demands for treatment. Preventing and adequately managing these complications are essential for ensuring the benefits of surgery.http://www.j-stroke.org/upload/pdf/jos-2015-01739.pdfmoyamoya diseasecerebral revascularizationtreatment outcome |
| spellingShingle | Tackeun Kim Chang Wan Oh Jae Seung Bang Jeong Eun Kim Won-Sang Cho Moyamoya Disease: Treatment and Outcomes Journal of Stroke moyamoya disease cerebral revascularization treatment outcome |
| title | Moyamoya Disease: Treatment and Outcomes |
| title_full | Moyamoya Disease: Treatment and Outcomes |
| title_fullStr | Moyamoya Disease: Treatment and Outcomes |
| title_full_unstemmed | Moyamoya Disease: Treatment and Outcomes |
| title_short | Moyamoya Disease: Treatment and Outcomes |
| title_sort | moyamoya disease treatment and outcomes |
| topic | moyamoya disease cerebral revascularization treatment outcome |
| url | http://www.j-stroke.org/upload/pdf/jos-2015-01739.pdf |
| work_keys_str_mv | AT tackeunkim moyamoyadiseasetreatmentandoutcomes AT changwanoh moyamoyadiseasetreatmentandoutcomes AT jaeseungbang moyamoyadiseasetreatmentandoutcomes AT jeongeunkim moyamoyadiseasetreatmentandoutcomes AT wonsangcho moyamoyadiseasetreatmentandoutcomes |