Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric condition. However, the biological mechanisms underlying this disease are still largely unknown or poorly understood. Considerable evidence indicates that PTSD results from dysfunction in highly-conserved b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00196/full |
| _version_ | 1811333163695210496 |
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| author | Michael J. Lisieski Andrew L. Eagle Alana C. Conti Alana C. Conti Israel Liberzon Israel Liberzon Shane A. Perrine |
| author_facet | Michael J. Lisieski Andrew L. Eagle Alana C. Conti Alana C. Conti Israel Liberzon Israel Liberzon Shane A. Perrine |
| author_sort | Michael J. Lisieski |
| collection | DOAJ |
| description | Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric condition. However, the biological mechanisms underlying this disease are still largely unknown or poorly understood. Considerable evidence indicates that PTSD results from dysfunction in highly-conserved brain systems involved in stress, anxiety, fear, and reward. Pre-clinical models of traumatic stress exposure are critical in defining the neurobiological mechanisms of PTSD, which will ultimately aid in the development of new treatments for PTSD. Single prolonged stress (SPS) is a pre-clinical model that displays behavioral, molecular, and physiological alterations that recapitulate many of the same alterations observed in PTSD, illustrating its validity and giving it utility as a model for investigating post-traumatic adaptations and pre-trauma risk and protective factors. In this manuscript, we review the present state of research using the SPS model, with the goals of (1) describing the utility of the SPS model as a tool for investigating post-trauma adaptations, (2) relating findings using the SPS model to findings in patients with PTSD, and (3) indicating research gaps and strategies to address them in order to improve our understanding of the pathophysiology of PTSD. |
| first_indexed | 2024-04-13T16:47:48Z |
| format | Article |
| id | doaj.art-daca04c416774946a87fee4f576eae51 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-13T16:47:48Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-daca04c416774946a87fee4f576eae512022-12-22T02:39:01ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-05-01910.3389/fpsyt.2018.00196328223Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress DisorderMichael J. Lisieski0Andrew L. Eagle1Alana C. Conti2Alana C. Conti3Israel Liberzon4Israel Liberzon5Shane A. Perrine6Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Physiology, Michigan State University, East Lansing, MI, United StatesResearch and Development Service, John D. Dingell Veterans Affairs Medical Center, Detroit, MI, United StatesDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, United StatesMental Health Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, United StatesDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United StatesPost-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric condition. However, the biological mechanisms underlying this disease are still largely unknown or poorly understood. Considerable evidence indicates that PTSD results from dysfunction in highly-conserved brain systems involved in stress, anxiety, fear, and reward. Pre-clinical models of traumatic stress exposure are critical in defining the neurobiological mechanisms of PTSD, which will ultimately aid in the development of new treatments for PTSD. Single prolonged stress (SPS) is a pre-clinical model that displays behavioral, molecular, and physiological alterations that recapitulate many of the same alterations observed in PTSD, illustrating its validity and giving it utility as a model for investigating post-traumatic adaptations and pre-trauma risk and protective factors. In this manuscript, we review the present state of research using the SPS model, with the goals of (1) describing the utility of the SPS model as a tool for investigating post-trauma adaptations, (2) relating findings using the SPS model to findings in patients with PTSD, and (3) indicating research gaps and strategies to address them in order to improve our understanding of the pathophysiology of PTSD.http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00196/fullPTSDsingle prolonged stressanxietyamygdalahippocampusprefrontal cortex |
| spellingShingle | Michael J. Lisieski Andrew L. Eagle Alana C. Conti Alana C. Conti Israel Liberzon Israel Liberzon Shane A. Perrine Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder Frontiers in Psychiatry PTSD single prolonged stress anxiety amygdala hippocampus prefrontal cortex |
| title | Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder |
| title_full | Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder |
| title_fullStr | Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder |
| title_full_unstemmed | Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder |
| title_short | Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder |
| title_sort | single prolonged stress a review of two decades of progress in a rodent model of post traumatic stress disorder |
| topic | PTSD single prolonged stress anxiety amygdala hippocampus prefrontal cortex |
| url | http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00196/full |
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