MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes
<p>Abstract</p> <p>Background</p> <p>Polyunsaturated fatty acids (PUFAs) such as γ-linolenic acid (GLA), arachidonic acid (AA) and docosahexaenoic acid (DHA) have cytotoxic action on glioma cells.</p> <p>Results</p> <p>We evaluated the cytotoxic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-09-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://www.lipidworld.com/content/10/1/173 |
| _version_ | 1818524767937888256 |
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| author | Das Undurti N Fehér Liliána Z Kitajka Klára Faragó Nóra Puskás László G |
| author_facet | Das Undurti N Fehér Liliána Z Kitajka Klára Faragó Nóra Puskás László G |
| author_sort | Das Undurti N |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Polyunsaturated fatty acids (PUFAs) such as γ-linolenic acid (GLA), arachidonic acid (AA) and docosahexaenoic acid (DHA) have cytotoxic action on glioma cells.</p> <p>Results</p> <p>We evaluated the cytotoxic action of GLA, AA and DHA on glioma cells with specific reference to the expression of miRNAs. Relative expression of miRNAs were assessed by using high throughput nanocapillary real-time PCR. Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as <it>cox2</it>, <it>irs1</it>, <it>irs2</it>, <it>ccnd1</it>, <it>itgb3</it>, <it>bcl2</it>, <it>sirt1</it>, <it>tp53inp1 </it>and <it>k-ras</it>.</p> <p>Conclusions</p> <p><it>Our </it>results highlight involvement of miRNAs in the induction of apoptosis in glioma cells by fatty acids and temozolomide.</p> |
| first_indexed | 2024-12-11T06:01:11Z |
| format | Article |
| id | doaj.art-dacbb6a42c99406580d3b6f610120d7a |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-11T06:01:11Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-dacbb6a42c99406580d3b6f610120d7a2022-12-22T01:18:29ZengBMCLipids in Health and Disease1476-511X2011-09-0110117310.1186/1476-511X-10-173MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changesDas Undurti NFehér Liliána ZKitajka KláraFaragó NóraPuskás László G<p>Abstract</p> <p>Background</p> <p>Polyunsaturated fatty acids (PUFAs) such as γ-linolenic acid (GLA), arachidonic acid (AA) and docosahexaenoic acid (DHA) have cytotoxic action on glioma cells.</p> <p>Results</p> <p>We evaluated the cytotoxic action of GLA, AA and DHA on glioma cells with specific reference to the expression of miRNAs. Relative expression of miRNAs were assessed by using high throughput nanocapillary real-time PCR. Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as <it>cox2</it>, <it>irs1</it>, <it>irs2</it>, <it>ccnd1</it>, <it>itgb3</it>, <it>bcl2</it>, <it>sirt1</it>, <it>tp53inp1 </it>and <it>k-ras</it>.</p> <p>Conclusions</p> <p><it>Our </it>results highlight involvement of miRNAs in the induction of apoptosis in glioma cells by fatty acids and temozolomide.</p>http://www.lipidworld.com/content/10/1/173PUFAmicro RNAglioblastomaapoptosis |
| spellingShingle | Das Undurti N Fehér Liliána Z Kitajka Klára Faragó Nóra Puskás László G MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes Lipids in Health and Disease PUFA micro RNA glioblastoma apoptosis |
| title | MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes |
| title_full | MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes |
| title_fullStr | MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes |
| title_full_unstemmed | MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes |
| title_short | MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes |
| title_sort | microrna profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis specific expression changes |
| topic | PUFA micro RNA glioblastoma apoptosis |
| url | http://www.lipidworld.com/content/10/1/173 |
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