Role of Partial Splenectomy in Hematologic Childhood Disorders
The spleen is a secondary lymphoid organ that belongs to the reticular-endothelial system, directly connected to blood circulation. The spleen is greatly involved in the immune response, especially against capsulated bacteria. Splenectomy plays a fundamental role in the treatment of numerous pediatr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/11/1436 |
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| author | Giorgio Attina’ Silvia Triarico Alberto Romano Palma Maurizi Stefano Mastrangelo Antonio Ruggiero |
| author_facet | Giorgio Attina’ Silvia Triarico Alberto Romano Palma Maurizi Stefano Mastrangelo Antonio Ruggiero |
| author_sort | Giorgio Attina’ |
| collection | DOAJ |
| description | The spleen is a secondary lymphoid organ that belongs to the reticular-endothelial system, directly connected to blood circulation. The spleen is greatly involved in the immune response, especially against capsulated bacteria. Splenectomy plays a fundamental role in the treatment of numerous pediatric hematologic disorders. Taking into account all the possible complications (especially infections) linked to this procedure, alternatives to total splenectomy have been sought. Partial splenectomy has been proposed as a treatment that allows the reduction of infectious risk. This approach has proven safe and feasible in most patients, but multicentric and prospective studies are necessary to more accurately define the indications for performing partial splenectomy. However, vaccinations and antibiotic prophylaxis remain fundamental for preventing serious infections, even in the case of partial splenectomy. We review anatomical and functional properties of the spleen, with a focus on medical or surgical indications to splenectomy, aiming to give practical educational information to patients and their families after splenectomy. Furthermore, we discuss the feasibility of partial splenectomy in children with hematologic diseases who require splenectomy. |
| first_indexed | 2024-03-10T05:10:24Z |
| format | Article |
| id | doaj.art-dacbdce4c9e64db3b85fd9cfb253d713 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T05:10:24Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-dacbdce4c9e64db3b85fd9cfb253d7132023-11-23T00:53:17ZengMDPI AGPathogens2076-08172021-11-011011143610.3390/pathogens10111436Role of Partial Splenectomy in Hematologic Childhood DisordersGiorgio Attina’0Silvia Triarico1Alberto Romano2Palma Maurizi3Stefano Mastrangelo4Antonio Ruggiero5Pediatric Oncology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyPediatric Oncology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyPediatric Oncology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyPediatric Oncology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyPediatric Oncology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyPediatric Oncology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyThe spleen is a secondary lymphoid organ that belongs to the reticular-endothelial system, directly connected to blood circulation. The spleen is greatly involved in the immune response, especially against capsulated bacteria. Splenectomy plays a fundamental role in the treatment of numerous pediatric hematologic disorders. Taking into account all the possible complications (especially infections) linked to this procedure, alternatives to total splenectomy have been sought. Partial splenectomy has been proposed as a treatment that allows the reduction of infectious risk. This approach has proven safe and feasible in most patients, but multicentric and prospective studies are necessary to more accurately define the indications for performing partial splenectomy. However, vaccinations and antibiotic prophylaxis remain fundamental for preventing serious infections, even in the case of partial splenectomy. We review anatomical and functional properties of the spleen, with a focus on medical or surgical indications to splenectomy, aiming to give practical educational information to patients and their families after splenectomy. Furthermore, we discuss the feasibility of partial splenectomy in children with hematologic diseases who require splenectomy.https://www.mdpi.com/2076-0817/10/11/1436partial splenectomychildrenprophylaxissepsishematologic disordersvaccinations |
| spellingShingle | Giorgio Attina’ Silvia Triarico Alberto Romano Palma Maurizi Stefano Mastrangelo Antonio Ruggiero Role of Partial Splenectomy in Hematologic Childhood Disorders Pathogens partial splenectomy children prophylaxis sepsis hematologic disorders vaccinations |
| title | Role of Partial Splenectomy in Hematologic Childhood Disorders |
| title_full | Role of Partial Splenectomy in Hematologic Childhood Disorders |
| title_fullStr | Role of Partial Splenectomy in Hematologic Childhood Disorders |
| title_full_unstemmed | Role of Partial Splenectomy in Hematologic Childhood Disorders |
| title_short | Role of Partial Splenectomy in Hematologic Childhood Disorders |
| title_sort | role of partial splenectomy in hematologic childhood disorders |
| topic | partial splenectomy children prophylaxis sepsis hematologic disorders vaccinations |
| url | https://www.mdpi.com/2076-0817/10/11/1436 |
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