HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy

HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy

Abstract Iron accumulation causes cell death and disrupts tissue functions, which necessitates chelation therapy to reduce iron overload. However, clinical utilization of deferoxamine (DFO), an iron chelator, has been documented to give rise to systemic adverse effects, including ocular toxicity. Th...

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Bibliographic Details
Main Authors: Yang Kong, Pei‐Kang Liu, Yao Li, Nicholas D Nolan, Peter M J Quinn, Chun‐Wei Hsu, Laura A Jenny, Jin Zhao, Xuan Cui, Ya‐Ju Chang, Katherine J Wert, Janet R Sparrow, Nan‐Kai Wang, Stephen H Tsang
Format: Article
Language:English
Published: Springer Nature 2023-01-01
Series:EMBO Molecular Medicine
Subjects:
HIF2α upregulation
iron deficiency
mitochondrial deficit
RPE atrophy
α‐ketoglutarate
Online Access:https://doi.org/10.15252/emmm.202216525

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