Serum estrogen and its soluble receptor levels in Egyptian patients with acute leukemia: case-control study
Abstract Background Acute leukemias are malignant neoplastic diseases that arise from either lymphoid [ALL] or myeloid [AML] cell lines that are distinguished by the proliferation of BM non-functional immature cells and subsequently released into the bloodstream. ALL is prevalent malignancy in young...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-08-01
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| Series: | Egyptian Journal of Medical Human Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43042-021-00186-5 |
| _version_ | 1818907942740557824 |
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| author | Samir Ali Abd El-Kaream Samia Abd El-Moneim Ebied Nadia Ali Sadek Dina Mohamed Saad Eman Attia Nadwan |
| author_facet | Samir Ali Abd El-Kaream Samia Abd El-Moneim Ebied Nadia Ali Sadek Dina Mohamed Saad Eman Attia Nadwan |
| author_sort | Samir Ali Abd El-Kaream |
| collection | DOAJ |
| description | Abstract Background Acute leukemias are malignant neoplastic diseases that arise from either lymphoid [ALL] or myeloid [AML] cell lines that are distinguished by the proliferation of BM non-functional immature cells and subsequently released into the bloodstream. ALL is prevalent malignancy in young, while AML in older. Diagnosis is usually routinely performed through peripheral blood count and smear then confirmed by BM aspirate. It is remarkable to notice that leukemia can be manifested at high, low, and even at normal leucocyte count. While treatment results have improved steadily over the last decades in younger and adults, limited changes have been in survival among subjects of age > 60 years. Aim of the work is to measure the serum estrogen [E2] and its soluble receptor [ER] levels in acute leukemia patients and extrapolate its possible clinical significance. This study included 40 [20 females and 20 males] healthy volunteers clinically free from any disease, 40 [20 females and 20 males] AML patients, and 40 [20 females and 20 males] ALL. To all subjects, serum E2 and its soluble ER level were investigated by ELISA. Results Serum E2 [pg/ml] level was lower in AML and ALL female and male patients groups than control group. Serum ER [ng/ml] level was lower in AML and ALL female and male patients groups than control group. Conclusion Estimation of serum E2 and its soluble ER level is of edifying diagnostic value. Determination of serum E2 and its soluble ER level in AML and ALL patients is of value in deciding treatment therapeutic target protocol. |
| first_indexed | 2024-12-19T22:03:08Z |
| format | Article |
| id | doaj.art-dad1b4ab2b1a468ca2b0466f52e3a22e |
| institution | Directory Open Access Journal |
| issn | 2090-2441 |
| language | English |
| last_indexed | 2024-12-19T22:03:08Z |
| publishDate | 2021-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj.art-dad1b4ab2b1a468ca2b0466f52e3a22e2022-12-21T20:04:06ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412021-08-0122111010.1186/s43042-021-00186-5Serum estrogen and its soluble receptor levels in Egyptian patients with acute leukemia: case-control studySamir Ali Abd El-Kaream0Samia Abd El-Moneim Ebied1Nadia Ali Sadek2Dina Mohamed Saad3Eman Attia Nadwan4Department of Applied Medical Chemistry, Medical Research Institute, Alexandria UniversityDepartment of Applied Medical Chemistry, Medical Research Institute, Alexandria UniversityDepartment of Hematology, Medical Research Institute, Alexandria UniversityDepartment of Applied Medical Chemistry, Medical Research Institute, Alexandria UniversityDepartment of Internal Medicine, Hematology Unit, Faculty of Medicine, Alexandria UniversityAbstract Background Acute leukemias are malignant neoplastic diseases that arise from either lymphoid [ALL] or myeloid [AML] cell lines that are distinguished by the proliferation of BM non-functional immature cells and subsequently released into the bloodstream. ALL is prevalent malignancy in young, while AML in older. Diagnosis is usually routinely performed through peripheral blood count and smear then confirmed by BM aspirate. It is remarkable to notice that leukemia can be manifested at high, low, and even at normal leucocyte count. While treatment results have improved steadily over the last decades in younger and adults, limited changes have been in survival among subjects of age > 60 years. Aim of the work is to measure the serum estrogen [E2] and its soluble receptor [ER] levels in acute leukemia patients and extrapolate its possible clinical significance. This study included 40 [20 females and 20 males] healthy volunteers clinically free from any disease, 40 [20 females and 20 males] AML patients, and 40 [20 females and 20 males] ALL. To all subjects, serum E2 and its soluble ER level were investigated by ELISA. Results Serum E2 [pg/ml] level was lower in AML and ALL female and male patients groups than control group. Serum ER [ng/ml] level was lower in AML and ALL female and male patients groups than control group. Conclusion Estimation of serum E2 and its soluble ER level is of edifying diagnostic value. Determination of serum E2 and its soluble ER level in AML and ALL patients is of value in deciding treatment therapeutic target protocol.https://doi.org/10.1186/s43042-021-00186-5EstrogenEstrogen receptorAcute leukemia |
| spellingShingle | Samir Ali Abd El-Kaream Samia Abd El-Moneim Ebied Nadia Ali Sadek Dina Mohamed Saad Eman Attia Nadwan Serum estrogen and its soluble receptor levels in Egyptian patients with acute leukemia: case-control study Egyptian Journal of Medical Human Genetics Estrogen Estrogen receptor Acute leukemia |
| title | Serum estrogen and its soluble receptor levels in Egyptian patients with acute leukemia: case-control study |
| title_full | Serum estrogen and its soluble receptor levels in Egyptian patients with acute leukemia: case-control study |
| title_fullStr | Serum estrogen and its soluble receptor levels in Egyptian patients with acute leukemia: case-control study |
| title_full_unstemmed | Serum estrogen and its soluble receptor levels in Egyptian patients with acute leukemia: case-control study |
| title_short | Serum estrogen and its soluble receptor levels in Egyptian patients with acute leukemia: case-control study |
| title_sort | serum estrogen and its soluble receptor levels in egyptian patients with acute leukemia case control study |
| topic | Estrogen Estrogen receptor Acute leukemia |
| url | https://doi.org/10.1186/s43042-021-00186-5 |
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