Molecular and Cellular Characterization of Human CD8 T Suppressor Cells

Bidirectional interactions between dendritic cells (DC) and Ag-experienced T cells initiate either a tolerogenic or immunogenic pathway. The outcome of these interactions is of crucial importance in malignancy, transplantation, and autoimmune diseases. Blockade of co-stimulation results in the induc...

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Bibliographic Details
Main Authors: Zheng Xu, Sophey Ho, Chih-Chao Chang, Qing-Yin Zhang, Elena-Rodica Vasilescu, George Vlad, Nicole Suciu-Foca
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
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Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00549/full
Description
Summary:Bidirectional interactions between dendritic cells (DC) and Ag-experienced T cells initiate either a tolerogenic or immunogenic pathway. The outcome of these interactions is of crucial importance in malignancy, transplantation, and autoimmune diseases. Blockade of co-stimulation results in the induction of T helper cell anergy and subsequent differentiation of antigen specific CD8+ T suppressor/regulatory cells (Ts). Ts. Primed in the presence of inhibitory signals exert their inhibitory function in an antigen specific manner, a feature with tremendous clinical potential. In transplantation or autoimmunity, antigen specific Ts can enforce tolerance to auto- or alloantigens, while otherwise leaving the immune response to pathogens uninhibited. Alternatively, blockade of inhibitory receptors results in the generation of cytolytic CD8+ T cells (CTL), which is vital towards defense against tumors and viral diseases. Because CD8 T cells are MHC Class I restricted, they are able to recognize HLA-bound antigenic peptides presented not only by APC, but also on parenchymal cells, thus eliciting or suppressing auto- or allo- immune reactions.
ISSN:1664-3224