Molecular and Cellular Characterization of Human CD8 T Suppressor Cells
Bidirectional interactions between dendritic cells (DC) and Ag-experienced T cells initiate either a tolerogenic or immunogenic pathway. The outcome of these interactions is of crucial importance in malignancy, transplantation, and autoimmune diseases. Blockade of co-stimulation results in the induc...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-11-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00549/full |
| _version_ | 1818428265286598656 |
|---|---|
| author | Zheng Xu Sophey Ho Chih-Chao Chang Qing-Yin Zhang Elena-Rodica Vasilescu George Vlad Nicole Suciu-Foca |
| author_facet | Zheng Xu Sophey Ho Chih-Chao Chang Qing-Yin Zhang Elena-Rodica Vasilescu George Vlad Nicole Suciu-Foca |
| author_sort | Zheng Xu |
| collection | DOAJ |
| description | Bidirectional interactions between dendritic cells (DC) and Ag-experienced T cells initiate either a tolerogenic or immunogenic pathway. The outcome of these interactions is of crucial importance in malignancy, transplantation, and autoimmune diseases. Blockade of co-stimulation results in the induction of T helper cell anergy and subsequent differentiation of antigen specific CD8+ T suppressor/regulatory cells (Ts). Ts. Primed in the presence of inhibitory signals exert their inhibitory function in an antigen specific manner, a feature with tremendous clinical potential. In transplantation or autoimmunity, antigen specific Ts can enforce tolerance to auto- or alloantigens, while otherwise leaving the immune response to pathogens uninhibited. Alternatively, blockade of inhibitory receptors results in the generation of cytolytic CD8+ T cells (CTL), which is vital towards defense against tumors and viral diseases. Because CD8 T cells are MHC Class I restricted, they are able to recognize HLA-bound antigenic peptides presented not only by APC, but also on parenchymal cells, thus eliciting or suppressing auto- or allo- immune reactions. |
| first_indexed | 2024-12-14T14:58:52Z |
| format | Article |
| id | doaj.art-dad4f7516fbb457ba101315162096c5b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T14:58:52Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dad4f7516fbb457ba101315162096c5b2022-12-21T22:56:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242016-11-01710.3389/fimmu.2016.00549226773Molecular and Cellular Characterization of Human CD8 T Suppressor CellsZheng Xu0Sophey Ho1Chih-Chao Chang2Qing-Yin Zhang3Elena-Rodica Vasilescu4George Vlad5Nicole Suciu-Foca6Columbia UniversityColumbia UniversityColumbia UniversityColumbia UniversityColumbia UniversityColumbia UniversityColumbia UniversityBidirectional interactions between dendritic cells (DC) and Ag-experienced T cells initiate either a tolerogenic or immunogenic pathway. The outcome of these interactions is of crucial importance in malignancy, transplantation, and autoimmune diseases. Blockade of co-stimulation results in the induction of T helper cell anergy and subsequent differentiation of antigen specific CD8+ T suppressor/regulatory cells (Ts). Ts. Primed in the presence of inhibitory signals exert their inhibitory function in an antigen specific manner, a feature with tremendous clinical potential. In transplantation or autoimmunity, antigen specific Ts can enforce tolerance to auto- or alloantigens, while otherwise leaving the immune response to pathogens uninhibited. Alternatively, blockade of inhibitory receptors results in the generation of cytolytic CD8+ T cells (CTL), which is vital towards defense against tumors and viral diseases. Because CD8 T cells are MHC Class I restricted, they are able to recognize HLA-bound antigenic peptides presented not only by APC, but also on parenchymal cells, thus eliciting or suppressing auto- or allo- immune reactions.http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00549/fullTransplantationautoimmune diseaseILT3Co-stimulation blockadeCD8+ T suppressor cellsgene profile of CD8+ Ts |
| spellingShingle | Zheng Xu Sophey Ho Chih-Chao Chang Qing-Yin Zhang Elena-Rodica Vasilescu George Vlad Nicole Suciu-Foca Molecular and Cellular Characterization of Human CD8 T Suppressor Cells Frontiers in Immunology Transplantation autoimmune disease ILT3 Co-stimulation blockade CD8+ T suppressor cells gene profile of CD8+ Ts |
| title | Molecular and Cellular Characterization of Human CD8 T Suppressor Cells |
| title_full | Molecular and Cellular Characterization of Human CD8 T Suppressor Cells |
| title_fullStr | Molecular and Cellular Characterization of Human CD8 T Suppressor Cells |
| title_full_unstemmed | Molecular and Cellular Characterization of Human CD8 T Suppressor Cells |
| title_short | Molecular and Cellular Characterization of Human CD8 T Suppressor Cells |
| title_sort | molecular and cellular characterization of human cd8 t suppressor cells |
| topic | Transplantation autoimmune disease ILT3 Co-stimulation blockade CD8+ T suppressor cells gene profile of CD8+ Ts |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00549/full |
| work_keys_str_mv | AT zhengxu molecularandcellularcharacterizationofhumancd8tsuppressorcells AT sopheyho molecularandcellularcharacterizationofhumancd8tsuppressorcells AT chihchaochang molecularandcellularcharacterizationofhumancd8tsuppressorcells AT qingyinzhang molecularandcellularcharacterizationofhumancd8tsuppressorcells AT elenarodicavasilescu molecularandcellularcharacterizationofhumancd8tsuppressorcells AT georgevlad molecularandcellularcharacterizationofhumancd8tsuppressorcells AT nicolesuciufoca molecularandcellularcharacterizationofhumancd8tsuppressorcells |