Nanoparticle-based delivery of siDCAMKL-1 increases <it>microRNA-144 </it>and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism

Nanoparticle-based delivery of siDCAMKL-1 increases <it>microRNA-144 </it>and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism

<p>Abstract</p> <p>Background</p> <p>The development of effective drug delivery systems capable of transporting small interfering RNA (siRNA) has been elusive. We have previously reported that colorectal cancer tumor xenograft growth was arrested following treatment wit...

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Bibliographic Details
Main Authors: Ponnurangam Sivapriya, Qu Dongfeng, Mondalek Fadee G, May Randal, Sureban Sripathi M, Pantazis Panayotis, Anant Shrikant, Ramanujam Rama P, Houchen Courtney W
Format: Article
Language:English
Published: BMC 2011-09-01
Series:Journal of Nanobiotechnology
Subjects:
DCAMKL-1
<it>miR-144</it>
microRNA
siRNA
notch signaling
nanoparticles
HCT116
tumor xenograft
cancer stem cells
Online Access:http://www.jnanobiotechnology.com/content/9/1/40

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