The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites.
Isoprenoid precursor synthesis is an ancient and fundamental function of plastid organelles and a critical metabolic activity of the apicoplast in Plasmodium malaria parasites [1-3]. Over the past decade, our understanding of apicoplast properties and functions has increased enormously [4], due in l...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-10-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1011713 |
| _version_ | 1797598048920010752 |
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| author | Megan Okada Paul A Sigala |
| author_facet | Megan Okada Paul A Sigala |
| author_sort | Megan Okada |
| collection | DOAJ |
| description | Isoprenoid precursor synthesis is an ancient and fundamental function of plastid organelles and a critical metabolic activity of the apicoplast in Plasmodium malaria parasites [1-3]. Over the past decade, our understanding of apicoplast properties and functions has increased enormously [4], due in large part to our ability to rescue blood-stage parasites from apicoplast-specific dysfunctions by supplementing cultures with isopentenyl pyrophosphate (IPP), a key output of this organelle [5,6]. In this Pearl, we explore the interdependence between isoprenoid metabolism and apicoplast biogenesis in P. falciparum and highlight critical future questions to answer. |
| first_indexed | 2024-03-11T03:13:53Z |
| format | Article |
| id | doaj.art-dad606e623ab4ca084574e4633cdda4f |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-03-11T03:13:53Z |
| publishDate | 2023-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-dad606e623ab4ca084574e4633cdda4f2023-11-18T05:31:25ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742023-10-011910e101171310.1371/journal.ppat.1011713The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites.Megan OkadaPaul A SigalaIsoprenoid precursor synthesis is an ancient and fundamental function of plastid organelles and a critical metabolic activity of the apicoplast in Plasmodium malaria parasites [1-3]. Over the past decade, our understanding of apicoplast properties and functions has increased enormously [4], due in large part to our ability to rescue blood-stage parasites from apicoplast-specific dysfunctions by supplementing cultures with isopentenyl pyrophosphate (IPP), a key output of this organelle [5,6]. In this Pearl, we explore the interdependence between isoprenoid metabolism and apicoplast biogenesis in P. falciparum and highlight critical future questions to answer.https://doi.org/10.1371/journal.ppat.1011713 |
| spellingShingle | Megan Okada Paul A Sigala The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites. PLoS Pathogens |
| title | The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites. |
| title_full | The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites. |
| title_fullStr | The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites. |
| title_full_unstemmed | The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites. |
| title_short | The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites. |
| title_sort | interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites |
| url | https://doi.org/10.1371/journal.ppat.1011713 |
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