Treatment of schizotypal disorder: a protocol for a systematic review of the evidence and recommendations for clinical practice
Introduction Schizotypal disorder is associated with a high level of disability at an individual level and high societal costs. However, clinical recommendations for the treatment of schizotypal disorder are scarce and based on limited evidence. This review aims to synthesise the current evidence on...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2023-11-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/11/e075140.full |
| _version_ | 1827619894341926912 |
|---|---|
| author | Bjørn H Ebdrup Louise Birkedal Glenthøj Kristina Ballestad Gundersen Andreas Rosén Rasmussen Katharina Oravsky Sandström Nikolai Albert Andrea Polari Barnaby Nelson |
| author_facet | Bjørn H Ebdrup Louise Birkedal Glenthøj Kristina Ballestad Gundersen Andreas Rosén Rasmussen Katharina Oravsky Sandström Nikolai Albert Andrea Polari Barnaby Nelson |
| author_sort | Bjørn H Ebdrup |
| collection | DOAJ |
| description | Introduction Schizotypal disorder is associated with a high level of disability at an individual level and high societal costs. However, clinical recommendations for the treatment of schizotypal disorder are scarce and based on limited evidence. This review aims to synthesise the current evidence on treatment for schizotypal disorder making recommendations for clinical practice.Methods and analysis This systematic review protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A systematic literature search will be performed in PsychArticles, Embase, Medline and Cochrane Central Register of Controlled Trials. Additionally, we will search for relevant articles manually. Inclusion criteria are published studies including individuals diagnosed with schizotypal personality disorder according to Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria, or schizotypal disorder according to International Classification of Diseases (ICD) criteria. We will include interventional studies comprising any pharmacological and non-pharmacological treatment trials for patients with schizotypal disorder, and all relevant outcome measures will be reported. Risk of bias will be assessed by Cochrane risk-of-bias tools. Data will be synthesised using narrative or thematic analysis and, if suitable, through meta-analysis.Ethics and dissemination No original data will be collected as part of this study and ethics approval is, therefore, not applicable. The results will be disseminated through peer-reviewed publication and presented at international scientific meetings. We will aim at submitting the final paper for publication within 4 months of completion of analyses. Furthermore, this systematic review will inform clinicians and researchers on the current state of evidence on treatment for schizotypal disorder. Findings may guide proposals for further research and potentially guide recommendations for clinical practice using the Grading of Recommendations Assessment, Development and Evaluation.PROSPERO registration number CRD42022375001. |
| first_indexed | 2024-03-09T10:39:05Z |
| format | Article |
| id | doaj.art-dada891d907e423595f228d9b0151b86 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-09T10:39:05Z |
| publishDate | 2023-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-dada891d907e423595f228d9b0151b862023-12-01T18:55:07ZengBMJ Publishing GroupBMJ Open2044-60552023-11-01131110.1136/bmjopen-2023-075140Treatment of schizotypal disorder: a protocol for a systematic review of the evidence and recommendations for clinical practiceBjørn H Ebdrup0Louise Birkedal Glenthøj1Kristina Ballestad Gundersen2Andreas Rosén Rasmussen3Katharina Oravsky Sandström4Nikolai Albert5Andrea Polari6Barnaby Nelson7Department of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, DenmarkVIRTU research group, Copenhagen Research Centre for Mental Health, Hellerup, DenmarkVIRTU research group, Copenhagen Research Centre for Mental Health, Hellerup, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, DenmarkCenter for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, DenmarkCentre for Youth Mental Health, The University of Melbourne, Melbourne, Victoria, AustraliaCentre for Youth Mental Health, The University of Melbourne, Melbourne, Victoria, AustraliaIntroduction Schizotypal disorder is associated with a high level of disability at an individual level and high societal costs. However, clinical recommendations for the treatment of schizotypal disorder are scarce and based on limited evidence. This review aims to synthesise the current evidence on treatment for schizotypal disorder making recommendations for clinical practice.Methods and analysis This systematic review protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A systematic literature search will be performed in PsychArticles, Embase, Medline and Cochrane Central Register of Controlled Trials. Additionally, we will search for relevant articles manually. Inclusion criteria are published studies including individuals diagnosed with schizotypal personality disorder according to Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria, or schizotypal disorder according to International Classification of Diseases (ICD) criteria. We will include interventional studies comprising any pharmacological and non-pharmacological treatment trials for patients with schizotypal disorder, and all relevant outcome measures will be reported. Risk of bias will be assessed by Cochrane risk-of-bias tools. Data will be synthesised using narrative or thematic analysis and, if suitable, through meta-analysis.Ethics and dissemination No original data will be collected as part of this study and ethics approval is, therefore, not applicable. The results will be disseminated through peer-reviewed publication and presented at international scientific meetings. We will aim at submitting the final paper for publication within 4 months of completion of analyses. Furthermore, this systematic review will inform clinicians and researchers on the current state of evidence on treatment for schizotypal disorder. Findings may guide proposals for further research and potentially guide recommendations for clinical practice using the Grading of Recommendations Assessment, Development and Evaluation.PROSPERO registration number CRD42022375001.https://bmjopen.bmj.com/content/13/11/e075140.full |
| spellingShingle | Bjørn H Ebdrup Louise Birkedal Glenthøj Kristina Ballestad Gundersen Andreas Rosén Rasmussen Katharina Oravsky Sandström Nikolai Albert Andrea Polari Barnaby Nelson Treatment of schizotypal disorder: a protocol for a systematic review of the evidence and recommendations for clinical practice BMJ Open |
| title | Treatment of schizotypal disorder: a protocol for a systematic review of the evidence and recommendations for clinical practice |
| title_full | Treatment of schizotypal disorder: a protocol for a systematic review of the evidence and recommendations for clinical practice |
| title_fullStr | Treatment of schizotypal disorder: a protocol for a systematic review of the evidence and recommendations for clinical practice |
| title_full_unstemmed | Treatment of schizotypal disorder: a protocol for a systematic review of the evidence and recommendations for clinical practice |
| title_short | Treatment of schizotypal disorder: a protocol for a systematic review of the evidence and recommendations for clinical practice |
| title_sort | treatment of schizotypal disorder a protocol for a systematic review of the evidence and recommendations for clinical practice |
| url | https://bmjopen.bmj.com/content/13/11/e075140.full |
| work_keys_str_mv | AT bjørnhebdrup treatmentofschizotypaldisorderaprotocolforasystematicreviewoftheevidenceandrecommendationsforclinicalpractice AT louisebirkedalglenthøj treatmentofschizotypaldisorderaprotocolforasystematicreviewoftheevidenceandrecommendationsforclinicalpractice AT kristinaballestadgundersen treatmentofschizotypaldisorderaprotocolforasystematicreviewoftheevidenceandrecommendationsforclinicalpractice AT andreasrosenrasmussen treatmentofschizotypaldisorderaprotocolforasystematicreviewoftheevidenceandrecommendationsforclinicalpractice AT katharinaoravskysandstrom treatmentofschizotypaldisorderaprotocolforasystematicreviewoftheevidenceandrecommendationsforclinicalpractice AT nikolaialbert treatmentofschizotypaldisorderaprotocolforasystematicreviewoftheevidenceandrecommendationsforclinicalpractice AT andreapolari treatmentofschizotypaldisorderaprotocolforasystematicreviewoftheevidenceandrecommendationsforclinicalpractice AT barnabynelson treatmentofschizotypaldisorderaprotocolforasystematicreviewoftheevidenceandrecommendationsforclinicalpractice |