Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis
Small-fiber neuropathy (SFN) is suggested to be involved in the pathogenesis of some types of autoimmune connective tissue diseases. SFN with a reduction in epidermal nerve fibers might affect sensory fibers and cause neuropathic symptoms, such as pruritus and pain, which are common in both dermatom...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/16/9030 |
| _version_ | 1797409843283230720 |
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| author | Lai-San Wong Chih-Hung Lee Yu-Ta Yen |
| author_facet | Lai-San Wong Chih-Hung Lee Yu-Ta Yen |
| author_sort | Lai-San Wong |
| collection | DOAJ |
| description | Small-fiber neuropathy (SFN) is suggested to be involved in the pathogenesis of some types of autoimmune connective tissue diseases. SFN with a reduction in epidermal nerve fibers might affect sensory fibers and cause neuropathic symptoms, such as pruritus and pain, which are common in both dermatomyositis (DM) and cutaneous lupus erythematosus (CLE). Nerve growth factor (NGF) has been recognized as important in nociception by regulating epidermal nerve fiber density and sensitizing the peripheral nervous system. The present study aimed to investigate whether SFN was associated with the cutaneous manifestations of DM and CLE. We also investigated the relationship between SFN and axon guidance molecules, such as NGF, amphiregulin (AREG), and semaphorin (Sema3A) in DM and CLE. To explore the molecular signaling, interleukin (IL)-18 and IL-31, which have been implicated in the cutaneous manifestation and neuropathic symptoms in DM, were examined in keratinocytes. Our results revealed that intraepidermal nerve fiber density (IENFD) was unchanged in patients with DM, but significantly reduced in IENFD in patients with CLE compared with healthy control. Increased epidermal expression of NGF and decreased expression of Sema3A were demonstrated in patients with DM. Furthermore, IL-18 and IL-31 both induced the production of NGF from keratinocytes. Taken together, IL-18 and IL-31 mediated epidermal NGF expression might contribute to the cutaneous neuropathic symptoms in DM, while SFN might be important for CLE. |
| first_indexed | 2024-03-09T04:21:22Z |
| format | Article |
| id | doaj.art-dade68fe55e84ab0a91ec2d89435af2d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:21:22Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dade68fe55e84ab0a91ec2d89435af2d2023-12-03T13:48:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012316903010.3390/ijms23169030Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in DermatomyositisLai-San Wong0Chih-Hung Lee1Yu-Ta Yen2Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Dermatology, Fooyin University Hospital, Pingtung 928, TaiwanSmall-fiber neuropathy (SFN) is suggested to be involved in the pathogenesis of some types of autoimmune connective tissue diseases. SFN with a reduction in epidermal nerve fibers might affect sensory fibers and cause neuropathic symptoms, such as pruritus and pain, which are common in both dermatomyositis (DM) and cutaneous lupus erythematosus (CLE). Nerve growth factor (NGF) has been recognized as important in nociception by regulating epidermal nerve fiber density and sensitizing the peripheral nervous system. The present study aimed to investigate whether SFN was associated with the cutaneous manifestations of DM and CLE. We also investigated the relationship between SFN and axon guidance molecules, such as NGF, amphiregulin (AREG), and semaphorin (Sema3A) in DM and CLE. To explore the molecular signaling, interleukin (IL)-18 and IL-31, which have been implicated in the cutaneous manifestation and neuropathic symptoms in DM, were examined in keratinocytes. Our results revealed that intraepidermal nerve fiber density (IENFD) was unchanged in patients with DM, but significantly reduced in IENFD in patients with CLE compared with healthy control. Increased epidermal expression of NGF and decreased expression of Sema3A were demonstrated in patients with DM. Furthermore, IL-18 and IL-31 both induced the production of NGF from keratinocytes. Taken together, IL-18 and IL-31 mediated epidermal NGF expression might contribute to the cutaneous neuropathic symptoms in DM, while SFN might be important for CLE.https://www.mdpi.com/1422-0067/23/16/9030cutaneous lupus erythematosusdermatomyositisnerve growth factorsmall-fiber neuropathy |
| spellingShingle | Lai-San Wong Chih-Hung Lee Yu-Ta Yen Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis International Journal of Molecular Sciences cutaneous lupus erythematosus dermatomyositis nerve growth factor small-fiber neuropathy |
| title | Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis |
| title_full | Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis |
| title_fullStr | Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis |
| title_full_unstemmed | Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis |
| title_short | Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis |
| title_sort | increased epidermal nerve growth factor without small fiber neuropathy in dermatomyositis |
| topic | cutaneous lupus erythematosus dermatomyositis nerve growth factor small-fiber neuropathy |
| url | https://www.mdpi.com/1422-0067/23/16/9030 |
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