“Ferula assa-foetida L” or “Foeniculum vulgare”? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blinded
Objective: There are few evaluation about the effects of Fennel and Ferula on human polycystic ovary syndrome (PCOS). The goals of this study were to evaluate and compare the effectiveness of two medicinal plants of the Apiaceae family (Fennel and Ferula) in management of PCOS.Materials and Methods:...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2023-05-01
|
| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | https://ajp.mums.ac.ir/article_21389_1d6e3a2339a521bf65d544cdb1fe2972.pdf |
| _version_ | 1797837269916188672 |
|---|---|
| author | Fatemeh Ghavi Fatemeh Shakeri Somayeh Abdolahian |
| author_facet | Fatemeh Ghavi Fatemeh Shakeri Somayeh Abdolahian |
| author_sort | Fatemeh Ghavi |
| collection | DOAJ |
| description | Objective: There are few evaluation about the effects of Fennel and Ferula on human polycystic ovary syndrome (PCOS). The goals of this study were to evaluate and compare the effectiveness of two medicinal plants of the Apiaceae family (Fennel and Ferula) in management of PCOS.Materials and Methods: The sample size was 47 participants with PCOS who were randomly divided into 3 groups. The Ferula assa-foetida L group received 100 mg of Ferula (n=14), the Foeniculum vulgare group received 46 mg of Fennel (n=15), and the placebo group received placebo twice daily for 3 months (n=14).Results: Before the intervention, there were no significant differences between groups in terms of clinical parameters, endometrial thickness, or ovarian volume. After the interventions, the number of ovarian follicles was decreased in the Ferula and Fennel groups as compared to the placebo group (p<0.05). The number of ovarian follicles in both ovaries in the Ferula and Fennel group decreased and this decrease was significant in the right side as compared to placebo group. Our findings showed significant changes in dehydroepiandrosterone sulfate (DEHAS) and thyroid-stimulating hormone (TSH) levels after the intervention (p<0.03) between the Ferula and Placebo groups.Conclusion: Since use of Ferula could make significant changes in TSH and DEHAS levels and decrease the number of right and left ovarian follicles compared to Fennel and placebo, it can be concluded that this herbal medicine is more effective than Fennel in managing PCOS. |
| first_indexed | 2024-04-09T15:23:04Z |
| format | Article |
| id | doaj.art-dade8efb53604b838ec22f84102e08f7 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-09T15:23:04Z |
| publishDate | 2023-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-dade8efb53604b838ec22f84102e08f72023-04-29T06:02:09ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492023-05-0113328028910.22038/ajp.2022.2138921389“Ferula assa-foetida L” or “Foeniculum vulgare”? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blindedFatemeh Ghavi0Fatemeh Shakeri1Somayeh Abdolahian2Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Fars, IranDepartment of Midwifery, School of Nursing and Midwifery, Jahrom University of Medical Sciences, Fars, IranDepartment of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, IranObjective: There are few evaluation about the effects of Fennel and Ferula on human polycystic ovary syndrome (PCOS). The goals of this study were to evaluate and compare the effectiveness of two medicinal plants of the Apiaceae family (Fennel and Ferula) in management of PCOS.Materials and Methods: The sample size was 47 participants with PCOS who were randomly divided into 3 groups. The Ferula assa-foetida L group received 100 mg of Ferula (n=14), the Foeniculum vulgare group received 46 mg of Fennel (n=15), and the placebo group received placebo twice daily for 3 months (n=14).Results: Before the intervention, there were no significant differences between groups in terms of clinical parameters, endometrial thickness, or ovarian volume. After the interventions, the number of ovarian follicles was decreased in the Ferula and Fennel groups as compared to the placebo group (p<0.05). The number of ovarian follicles in both ovaries in the Ferula and Fennel group decreased and this decrease was significant in the right side as compared to placebo group. Our findings showed significant changes in dehydroepiandrosterone sulfate (DEHAS) and thyroid-stimulating hormone (TSH) levels after the intervention (p<0.03) between the Ferula and Placebo groups.Conclusion: Since use of Ferula could make significant changes in TSH and DEHAS levels and decrease the number of right and left ovarian follicles compared to Fennel and placebo, it can be concluded that this herbal medicine is more effective than Fennel in managing PCOS.https://ajp.mums.ac.ir/article_21389_1d6e3a2339a521bf65d544cdb1fe2972.pdfferulaferula assa-foetida lfennel, foeniculum vulgare, polycystic ovarian syndromepcos |
| spellingShingle | Fatemeh Ghavi Fatemeh Shakeri Somayeh Abdolahian “Ferula assa-foetida L” or “Foeniculum vulgare”? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blinded Avicenna Journal of Phytomedicine ferula ferula assa-foetida l fennel, foeniculum vulgare, polycystic ovarian syndrome pcos |
| title | “Ferula assa-foetida L” or “Foeniculum vulgare”? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blinded |
| title_full | “Ferula assa-foetida L” or “Foeniculum vulgare”? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blinded |
| title_fullStr | “Ferula assa-foetida L” or “Foeniculum vulgare”? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blinded |
| title_full_unstemmed | “Ferula assa-foetida L” or “Foeniculum vulgare”? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blinded |
| title_short | “Ferula assa-foetida L” or “Foeniculum vulgare”? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blinded |
| title_sort | ferula assa foetida l or foeniculum vulgare which one is more effective in the management of polycystic ovarian syndrome a randomized placebo controlled triple blinded |
| topic | ferula ferula assa-foetida l fennel, foeniculum vulgare, polycystic ovarian syndrome pcos |
| url | https://ajp.mums.ac.ir/article_21389_1d6e3a2339a521bf65d544cdb1fe2972.pdf |
| work_keys_str_mv | AT fatemehghavi ferulaassafoetidalorfoeniculumvulgarewhichoneismoreeffectiveinthemanagementofpolycysticovariansyndromearandomizedplacebocontrolledtripleblinded AT fatemehshakeri ferulaassafoetidalorfoeniculumvulgarewhichoneismoreeffectiveinthemanagementofpolycysticovariansyndromearandomizedplacebocontrolledtripleblinded AT somayehabdolahian ferulaassafoetidalorfoeniculumvulgarewhichoneismoreeffectiveinthemanagementofpolycysticovariansyndromearandomizedplacebocontrolledtripleblinded |