Bone microarchitecture and bone mineral density in Graves’ disease
Objectives: Graves' disease (GD) is the most common cause of thyrotoxicosis. There are many studies that have evaluated bone mineral density (BMD) in Graves’ disease. However, the strength of a bone also depends on its microarchitecture which can be assessed by various techniques. Trabecular bo...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Osteoporosis and Sarcopenia |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405525523000262 |
| _version_ | 1797781884904669184 |
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| author | Hiya Boro Rakhi Malhotra Suraj Kubihal Saurav Khatiwada Vinay Dogra Velmurugan Mannar Ashok Kumar Ahirwar Vandana Rastogi |
| author_facet | Hiya Boro Rakhi Malhotra Suraj Kubihal Saurav Khatiwada Vinay Dogra Velmurugan Mannar Ashok Kumar Ahirwar Vandana Rastogi |
| author_sort | Hiya Boro |
| collection | DOAJ |
| description | Objectives: Graves' disease (GD) is the most common cause of thyrotoxicosis. There are many studies that have evaluated bone mineral density (BMD) in Graves’ disease. However, the strength of a bone also depends on its microarchitecture which can be assessed by various techniques. Trabecular bone score (TBS) is a new method for assessing bone microarchitecture that is non-invasive and easily performed. Methods: The present study was a cross-sectional study that involved 50 patients with active GD and 50 healthy controls. Both groups were subjected to an assessment of biochemical parameters followed by measurement of BMD and TBS on the same dual energy X-ray absorptiometry (DXA) machine. Results: The mean age of patients with active GD (N = 50) was 31.9 ± 10.9 years while that of controls was 31.2 ± 4.9 years (P = 0.640). The female: male ratio was the same for both groups (F = 31, M = 19). The mean lumbar spine BMD, femoral neck BMD, total hip BMD, and distal radius BMD were significantly reduced in GD when compared to that in controls. The mean absolute lumbar spine TBS in GD was 1.263 ± 0.101 while that in controls was 1.368 ± 0.073 (P < 0.001). On multivariate regression analysis, the factors that predicted TBS were serum thyroxine (T4) and L1-L4 BMD. Conclusions: Patients with Graves’ disease had reduced bone density at all sites and degraded microarchitecture. Long-term studies are required to understand the pattern of recovery of bone microarchitecture after the restoration of euthyroidism. |
| first_indexed | 2024-03-13T00:03:12Z |
| format | Article |
| id | doaj.art-dadf9274178d4cbd8f374db72d25a7a8 |
| institution | Directory Open Access Journal |
| issn | 2405-5255 |
| language | English |
| last_indexed | 2024-03-13T00:03:12Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoporosis and Sarcopenia |
| spelling | doaj.art-dadf9274178d4cbd8f374db72d25a7a82023-07-13T05:30:27ZengElsevierOsteoporosis and Sarcopenia2405-52552023-06-01927075Bone microarchitecture and bone mineral density in Graves’ diseaseHiya Boro0Rakhi Malhotra1Suraj Kubihal2Saurav Khatiwada3Vinay Dogra4Velmurugan Mannar5Ashok Kumar Ahirwar6Vandana Rastogi7Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India; Corresponding author.Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, IndiaDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, IndiaDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, IndiaDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, IndiaDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, IndiaDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, IndiaDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, IndiaObjectives: Graves' disease (GD) is the most common cause of thyrotoxicosis. There are many studies that have evaluated bone mineral density (BMD) in Graves’ disease. However, the strength of a bone also depends on its microarchitecture which can be assessed by various techniques. Trabecular bone score (TBS) is a new method for assessing bone microarchitecture that is non-invasive and easily performed. Methods: The present study was a cross-sectional study that involved 50 patients with active GD and 50 healthy controls. Both groups were subjected to an assessment of biochemical parameters followed by measurement of BMD and TBS on the same dual energy X-ray absorptiometry (DXA) machine. Results: The mean age of patients with active GD (N = 50) was 31.9 ± 10.9 years while that of controls was 31.2 ± 4.9 years (P = 0.640). The female: male ratio was the same for both groups (F = 31, M = 19). The mean lumbar spine BMD, femoral neck BMD, total hip BMD, and distal radius BMD were significantly reduced in GD when compared to that in controls. The mean absolute lumbar spine TBS in GD was 1.263 ± 0.101 while that in controls was 1.368 ± 0.073 (P < 0.001). On multivariate regression analysis, the factors that predicted TBS were serum thyroxine (T4) and L1-L4 BMD. Conclusions: Patients with Graves’ disease had reduced bone density at all sites and degraded microarchitecture. Long-term studies are required to understand the pattern of recovery of bone microarchitecture after the restoration of euthyroidism.http://www.sciencedirect.com/science/article/pii/S2405525523000262Graves' diseaseSecondary osteoporosisBone mineral densityTrabecular bone scoreThyroxine |
| spellingShingle | Hiya Boro Rakhi Malhotra Suraj Kubihal Saurav Khatiwada Vinay Dogra Velmurugan Mannar Ashok Kumar Ahirwar Vandana Rastogi Bone microarchitecture and bone mineral density in Graves’ disease Osteoporosis and Sarcopenia Graves' disease Secondary osteoporosis Bone mineral density Trabecular bone score Thyroxine |
| title | Bone microarchitecture and bone mineral density in Graves’ disease |
| title_full | Bone microarchitecture and bone mineral density in Graves’ disease |
| title_fullStr | Bone microarchitecture and bone mineral density in Graves’ disease |
| title_full_unstemmed | Bone microarchitecture and bone mineral density in Graves’ disease |
| title_short | Bone microarchitecture and bone mineral density in Graves’ disease |
| title_sort | bone microarchitecture and bone mineral density in graves disease |
| topic | Graves' disease Secondary osteoporosis Bone mineral density Trabecular bone score Thyroxine |
| url | http://www.sciencedirect.com/science/article/pii/S2405525523000262 |
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