Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach
Type I Bipolar disorder (BD-I) is a neuropsychiatric disorder characterized by manic or mixed-featured episodes, impaired cognitive functioning, and persistent work and social functioning impairment. This study aimed to investigate within-subject; (i) differences in brain perfusion using Single-phot...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1244134/full |
| _version_ | 1827799972152606720 |
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| author | Maria Anayali Estudillo-Guerra Maria Anayali Estudillo-Guerra Clas Linnman Victor Galvez Gina Chapa-Koloffon Kevin Pacheco-Barrios Kevin Pacheco-Barrios Leon Morales-Quezada Monica Flores Ramos Monica Flores Ramos |
| author_facet | Maria Anayali Estudillo-Guerra Maria Anayali Estudillo-Guerra Clas Linnman Victor Galvez Gina Chapa-Koloffon Kevin Pacheco-Barrios Kevin Pacheco-Barrios Leon Morales-Quezada Monica Flores Ramos Monica Flores Ramos |
| author_sort | Maria Anayali Estudillo-Guerra |
| collection | DOAJ |
| description | Type I Bipolar disorder (BD-I) is a neuropsychiatric disorder characterized by manic or mixed-featured episodes, impaired cognitive functioning, and persistent work and social functioning impairment. This study aimed to investigate within-subject; (i) differences in brain perfusion using Single-photon emission computed tomography (SPECT) between manic and euthymic states in BD-I patients; (ii) explore potential associations between altered brain perfusion and cognitive status; and (iii) examine the relationship between cerebral perfusion and mania symptom ratings. Seventeen adult patients diagnosed with BD-I in a manic episode were recruited, and clinical assessments, cognitive tests, and brain perfusion studies were conducted at baseline (mania state) and a follow-up visit 6 months later. The results showed cognitive impairment during the manic episode, which persisted during the euthymic state at follow-up. However, no significant changes in brain perfusion were observed between the manic and euthymic states. During mania, trends toward decreased perfusion in the left cerebellum and right superior parietal lobule were noted. Additionally, trends indicated a higher perfusion imbalance in the left superior and middle frontal gyrus during mania and the right superior and middle frontal gyrus during euthymia. No significant correlations existed between brain perfusion, mania symptom ratings, and cognitive performance, indicating that symptomatology might represent more than neural hemodynamics. These findings suggest that cognitive impairment may persist in BD-I patients and highlight the need for therapeutic interventions targeting cognitive deficits. More extensive studies with extended follow-up periods are warranted further to investigate brain perfusion and cognitive functioning in BD-I patients. |
| first_indexed | 2024-03-11T19:59:53Z |
| format | Article |
| id | doaj.art-dae03d6c48c841c7be90651981f9312b |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-11T19:59:53Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-dae03d6c48c841c7be90651981f9312b2023-10-04T10:00:18ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-10-011410.3389/fpsyt.2023.12441341244134Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approachMaria Anayali Estudillo-Guerra0Maria Anayali Estudillo-Guerra1Clas Linnman2Victor Galvez3Gina Chapa-Koloffon4Kevin Pacheco-Barrios5Kevin Pacheco-Barrios6Leon Morales-Quezada7Monica Flores Ramos8Monica Flores Ramos9Clínica de Trastornos del Afecto, Instituto Nacional de Psiquiatría “Ramón de la Fuente”, Mexico City, MexicoSpaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesSpaulding Neuroimaging Laboratory, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Boston, MA, United StatesLaboratorio de Neurociencias Cognitivas y Desarrollo, Escuela de Psicología, Universidad Panamericana, Mexico City, MexicoHospital Infantil de Mexico Federico Gómez, Mexico City, MexicoNeuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesVicerrectorado de Investigación, Unidad de Investigación Para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, PeruSpaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesSubdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoType I Bipolar disorder (BD-I) is a neuropsychiatric disorder characterized by manic or mixed-featured episodes, impaired cognitive functioning, and persistent work and social functioning impairment. This study aimed to investigate within-subject; (i) differences in brain perfusion using Single-photon emission computed tomography (SPECT) between manic and euthymic states in BD-I patients; (ii) explore potential associations between altered brain perfusion and cognitive status; and (iii) examine the relationship between cerebral perfusion and mania symptom ratings. Seventeen adult patients diagnosed with BD-I in a manic episode were recruited, and clinical assessments, cognitive tests, and brain perfusion studies were conducted at baseline (mania state) and a follow-up visit 6 months later. The results showed cognitive impairment during the manic episode, which persisted during the euthymic state at follow-up. However, no significant changes in brain perfusion were observed between the manic and euthymic states. During mania, trends toward decreased perfusion in the left cerebellum and right superior parietal lobule were noted. Additionally, trends indicated a higher perfusion imbalance in the left superior and middle frontal gyrus during mania and the right superior and middle frontal gyrus during euthymia. No significant correlations existed between brain perfusion, mania symptom ratings, and cognitive performance, indicating that symptomatology might represent more than neural hemodynamics. These findings suggest that cognitive impairment may persist in BD-I patients and highlight the need for therapeutic interventions targeting cognitive deficits. More extensive studies with extended follow-up periods are warranted further to investigate brain perfusion and cognitive functioning in BD-I patients.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1244134/fullbipolar disorderSPECTbrain imagingcognitive functionneuroimagingnuclear medicine |
| spellingShingle | Maria Anayali Estudillo-Guerra Maria Anayali Estudillo-Guerra Clas Linnman Victor Galvez Gina Chapa-Koloffon Kevin Pacheco-Barrios Kevin Pacheco-Barrios Leon Morales-Quezada Monica Flores Ramos Monica Flores Ramos Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach Frontiers in Psychiatry bipolar disorder SPECT brain imaging cognitive function neuroimaging nuclear medicine |
| title | Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach |
| title_full | Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach |
| title_fullStr | Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach |
| title_full_unstemmed | Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach |
| title_short | Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach |
| title_sort | is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type i a longitudinal study using perfusion imaging approach |
| topic | bipolar disorder SPECT brain imaging cognitive function neuroimaging nuclear medicine |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1244134/full |
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