Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study
Abstract Background Chronic kidney disease (CKD) involves many factors that can cause frailty and oral hypofunction. We aimed to investigate the prevalence of frailty and oral hypofunction and to examine the associations among kidney function, frailty, and oral function in adults with CKD in Japan....
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-020-02019-w |
| _version_ | 1819145293435764736 |
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| author | Shiho Kosaka Yuki Ohara Shotaro Naito Soichiro Iimori Hiroshi Kado Tsuguru Hatta Masaaki Yanishi Shinichi Uchida Makoto Tanaka |
| author_facet | Shiho Kosaka Yuki Ohara Shotaro Naito Soichiro Iimori Hiroshi Kado Tsuguru Hatta Masaaki Yanishi Shinichi Uchida Makoto Tanaka |
| author_sort | Shiho Kosaka |
| collection | DOAJ |
| description | Abstract Background Chronic kidney disease (CKD) involves many factors that can cause frailty and oral hypofunction. We aimed to investigate the prevalence of frailty and oral hypofunction and to examine the associations among kidney function, frailty, and oral function in adults with CKD in Japan. Methods This cross-sectional study was conducted at two institutions. The participants included 109 patients with CKD stages 3–5 who visited outpatient clinics or were admitted for inpatient treatment. Frailty was evaluated using the Japanese version of the Cardiovascular Health Study frailty criteria. Oral function was evaluated by assessing oral motor skills [oral diadochokinesis (ODK) rate], masticatory ability, and the repetitive saliva swallowing test. The estimated glomerular filtration rate (eGFR) was used to indicate kidney function. We examined the associations among kidney function, frailty, and oral function using binomial logistic regression analysis. Results In total, 31 participants (28.4%) were classified as being frail. Univariate analysis showed that age, body mass index, eGFR, and haemoglobin level were significantly associated with frailty. ODK and swallowing function were significantly associated with frailty. Multivariate analysis revealed that frailty was significantly associated with eGFR [odds ratio (OR) 0.96, 95% confidence interval (CI) 0.92–1.00, p = 0.048] and ODK rate (OR 0.68, CI 0.47–0.98, p = 0.038). However, no significant association was found between CKD severity and masticatory or swallowing function. Conclusion We found a high prevalence of frailty in patients with CKD and a significant association between frailty and oral motor skills, affecting the swallowing function of patients with nondialysis CKD. The high prevalence of frailty among patients with CKD suggests that routine assessment of frailty is necessary to prevent the development of severe complications. In addition, oral and kidney function should be carefully evaluated, and oral health education and interventions should be performed for patients with CKD. |
| first_indexed | 2024-12-22T12:55:44Z |
| format | Article |
| id | doaj.art-dae08c03a4364294a8db14cbaadad14e |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-22T12:55:44Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-dae08c03a4364294a8db14cbaadad14e2022-12-21T18:25:07ZengBMCBMC Nephrology1471-23692020-08-012111810.1186/s12882-020-02019-wAssociation among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional studyShiho Kosaka0Yuki Ohara1Shotaro Naito2Soichiro Iimori3Hiroshi Kado4Tsuguru Hatta5Masaaki Yanishi6Shinichi Uchida7Makoto Tanaka8Critical and Invasive-Palliative Care Nursing, Graduate School of Health Care Sciences, Tokyo Medical and Dental UniversityTokyo Metropolitan Institute of GerontologyDepartment of Nephrology, Tokyo Medical and Dental UniversityDepartment of Nephrology, Tokyo Medical and Dental UniversityOmihachiman Community Medical CenterOmihachiman Community Medical CenterKansai Medical UniversityDepartment of Nephrology, Tokyo Medical and Dental UniversityCritical and Invasive-Palliative Care Nursing, Graduate School of Health Care Sciences, Tokyo Medical and Dental UniversityAbstract Background Chronic kidney disease (CKD) involves many factors that can cause frailty and oral hypofunction. We aimed to investigate the prevalence of frailty and oral hypofunction and to examine the associations among kidney function, frailty, and oral function in adults with CKD in Japan. Methods This cross-sectional study was conducted at two institutions. The participants included 109 patients with CKD stages 3–5 who visited outpatient clinics or were admitted for inpatient treatment. Frailty was evaluated using the Japanese version of the Cardiovascular Health Study frailty criteria. Oral function was evaluated by assessing oral motor skills [oral diadochokinesis (ODK) rate], masticatory ability, and the repetitive saliva swallowing test. The estimated glomerular filtration rate (eGFR) was used to indicate kidney function. We examined the associations among kidney function, frailty, and oral function using binomial logistic regression analysis. Results In total, 31 participants (28.4%) were classified as being frail. Univariate analysis showed that age, body mass index, eGFR, and haemoglobin level were significantly associated with frailty. ODK and swallowing function were significantly associated with frailty. Multivariate analysis revealed that frailty was significantly associated with eGFR [odds ratio (OR) 0.96, 95% confidence interval (CI) 0.92–1.00, p = 0.048] and ODK rate (OR 0.68, CI 0.47–0.98, p = 0.038). However, no significant association was found between CKD severity and masticatory or swallowing function. Conclusion We found a high prevalence of frailty in patients with CKD and a significant association between frailty and oral motor skills, affecting the swallowing function of patients with nondialysis CKD. The high prevalence of frailty among patients with CKD suggests that routine assessment of frailty is necessary to prevent the development of severe complications. In addition, oral and kidney function should be carefully evaluated, and oral health education and interventions should be performed for patients with CKD.http://link.springer.com/article/10.1186/s12882-020-02019-wChronic kidney diseaseFrailtyOral functionKidney function |
| spellingShingle | Shiho Kosaka Yuki Ohara Shotaro Naito Soichiro Iimori Hiroshi Kado Tsuguru Hatta Masaaki Yanishi Shinichi Uchida Makoto Tanaka Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study BMC Nephrology Chronic kidney disease Frailty Oral function Kidney function |
| title | Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study |
| title_full | Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study |
| title_fullStr | Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study |
| title_full_unstemmed | Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study |
| title_short | Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study |
| title_sort | association among kidney function frailty and oral function in patients with chronic kidney disease a cross sectional study |
| topic | Chronic kidney disease Frailty Oral function Kidney function |
| url | http://link.springer.com/article/10.1186/s12882-020-02019-w |
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