Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE)
Diabetes and Alzheimer’s disease (AD) place a significant burden on health care systems in the world and its aging populations. These diseases have long been regarded as separate entities; however, advanced glycation end products (AGEs) and the receptors for AGEs (RAGE) may be a link between diabete...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2020.00217/full |
| _version_ | 1828450962131386368 |
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| author | Yanyan Kong Yanyan Kong Fushuai Wang Jiao Wang Cuiping Liu Yinping Zhou Zhengqin Xu Chencheng Zhang Bomin Sun Yihui Guan |
| author_facet | Yanyan Kong Yanyan Kong Fushuai Wang Jiao Wang Cuiping Liu Yinping Zhou Zhengqin Xu Chencheng Zhang Bomin Sun Yihui Guan |
| author_sort | Yanyan Kong |
| collection | DOAJ |
| description | Diabetes and Alzheimer’s disease (AD) place a significant burden on health care systems in the world and its aging populations. These diseases have long been regarded as separate entities; however, advanced glycation end products (AGEs) and the receptors for AGEs (RAGE) may be a link between diabetes and AD. In our study, mice injected with AGEs through stereotaxic surgery showed significant AD-like features: behavior showed decreased memory; immunofluorescence showed increased phosphorylated tau and APP. These results suggest links between diabetes and AD. Patients with diabetes are at a higher risk of developing AD, and the possible underlying molecular components of this association are now beginning to emerge. |
| first_indexed | 2024-12-10T23:30:11Z |
| format | Article |
| id | doaj.art-dae2d87baf264a99b8d02fb78d18c2ed |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-10T23:30:11Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-dae2d87baf264a99b8d02fb78d18c2ed2022-12-22T01:29:26ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-07-011210.3389/fnagi.2020.00217546386Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE)Yanyan Kong0Yanyan Kong1Fushuai Wang2Jiao Wang3Cuiping Liu4Yinping Zhou5Zhengqin Xu6Chencheng Zhang7Bomin Sun8Yihui Guan9Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaPET Center, Huashan Hospital, Fudan University, Shanghai, ChinaLaboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, ChinaLaboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, ChinaLaboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, ChinaLaboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, ChinaLaboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, ChinaDepartment of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaPET Center, Huashan Hospital, Fudan University, Shanghai, ChinaDiabetes and Alzheimer’s disease (AD) place a significant burden on health care systems in the world and its aging populations. These diseases have long been regarded as separate entities; however, advanced glycation end products (AGEs) and the receptors for AGEs (RAGE) may be a link between diabetes and AD. In our study, mice injected with AGEs through stereotaxic surgery showed significant AD-like features: behavior showed decreased memory; immunofluorescence showed increased phosphorylated tau and APP. These results suggest links between diabetes and AD. Patients with diabetes are at a higher risk of developing AD, and the possible underlying molecular components of this association are now beginning to emerge.https://www.frontiersin.org/article/10.3389/fnagi.2020.00217/fulladvanced glycation end productsRAGEAlzheimer’s diseasediabetesPI3K |
| spellingShingle | Yanyan Kong Yanyan Kong Fushuai Wang Jiao Wang Cuiping Liu Yinping Zhou Zhengqin Xu Chencheng Zhang Bomin Sun Yihui Guan Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE) Frontiers in Aging Neuroscience advanced glycation end products RAGE Alzheimer’s disease diabetes PI3K |
| title | Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE) |
| title_full | Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE) |
| title_fullStr | Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE) |
| title_full_unstemmed | Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE) |
| title_short | Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE) |
| title_sort | pathological mechanisms linking diabetes mellitus and alzheimer s disease the receptor for advanced glycation end products rage |
| topic | advanced glycation end products RAGE Alzheimer’s disease diabetes PI3K |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2020.00217/full |
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