Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia.
<h4>Background</h4>Shigella is a leading cause of bacterial diarrhea morbidity and mortality affecting mainly children under five in the developing world. In Zambia, Shigella has a high prevalence of 34.7% in children with diarrhea and an attributable fraction of 6.7% in Zambian children...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0279012 |
| _version_ | 1797856383292407808 |
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| author | Sam Miti Obvious N Chilyabanyama Caroline C Chisenga Mwelwa Chibuye Samuel Bosomprah Chisenga Mumba Salome Chitondo Seter Siziya Dani Cohen Roma Chilengi Michelo Simuyandi |
| author_facet | Sam Miti Obvious N Chilyabanyama Caroline C Chisenga Mwelwa Chibuye Samuel Bosomprah Chisenga Mumba Salome Chitondo Seter Siziya Dani Cohen Roma Chilengi Michelo Simuyandi |
| author_sort | Sam Miti |
| collection | DOAJ |
| description | <h4>Background</h4>Shigella is a leading cause of bacterial diarrhea morbidity and mortality affecting mainly children under five in the developing world. In Zambia, Shigella has a high prevalence of 34.7% in children with diarrhea and an attributable fraction of 6.7% in Zambian children with moderate to severe diarrhea. Zambian diarrhea management guidelines and the health ministry reporting tool Health Management Information System (HMIS) heavily rely on the WHO clinical classification of dysentery to potentially identify and estimate the burden of Shigella in children. This reliance on clinical dysentery as a proxy to shigellosis in under five children may be resulting in gross under-estimation of shigella disease burden in Zambia.<h4>Methods</h4>We used existing laboratory and clinical data to examine the sensitivity and predictive value of dysentery to correctly identify Shigella infection in under five children with PCR confirmed Shigella infection in Lusaka and Ndola districts, Zambia.<h4>Results</h4>Clinical dysentery had a sensitivity of 8.5% (34/401) in identifying under five children with Shigella by stool PCR. Dysentery was able to correctly classify Shigella in 34 of 68 bloody stool samples giving a corresponding positive predictive value of 50%. Of the 1087 with non-bloody diarrhea, 720 did not have Shigella giving a negative predictive value of 66.2%.<h4>Conclusions</h4>Use of clinical dysentery as a screening symptom for Shigella infection in children under five presenting with moderate to severe diarrhea has low sensitivity and low positive predictive value respectively. Clinical dysentery as a screening symptom for Shigella contributes to gross under diagnosis and reporting of Shigella infection among under five children in Zambia. Further research is required to better inform practice on more accurate methods or tools to use in support of routine diagnosis, particularly in low middle-income settings where laboratory diagnosis remains a challenge. |
| first_indexed | 2024-04-09T20:39:32Z |
| format | Article |
| id | doaj.art-dae36a83d2e64dfc9e1a8d7ce32a10f5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T20:39:32Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dae36a83d2e64dfc9e1a8d7ce32a10f52023-03-30T05:31:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01182e027901210.1371/journal.pone.0279012Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia.Sam MitiObvious N ChilyabanyamaCaroline C ChisengaMwelwa ChibuyeSamuel BosomprahChisenga MumbaSalome ChitondoSeter SiziyaDani CohenRoma ChilengiMichelo Simuyandi<h4>Background</h4>Shigella is a leading cause of bacterial diarrhea morbidity and mortality affecting mainly children under five in the developing world. In Zambia, Shigella has a high prevalence of 34.7% in children with diarrhea and an attributable fraction of 6.7% in Zambian children with moderate to severe diarrhea. Zambian diarrhea management guidelines and the health ministry reporting tool Health Management Information System (HMIS) heavily rely on the WHO clinical classification of dysentery to potentially identify and estimate the burden of Shigella in children. This reliance on clinical dysentery as a proxy to shigellosis in under five children may be resulting in gross under-estimation of shigella disease burden in Zambia.<h4>Methods</h4>We used existing laboratory and clinical data to examine the sensitivity and predictive value of dysentery to correctly identify Shigella infection in under five children with PCR confirmed Shigella infection in Lusaka and Ndola districts, Zambia.<h4>Results</h4>Clinical dysentery had a sensitivity of 8.5% (34/401) in identifying under five children with Shigella by stool PCR. Dysentery was able to correctly classify Shigella in 34 of 68 bloody stool samples giving a corresponding positive predictive value of 50%. Of the 1087 with non-bloody diarrhea, 720 did not have Shigella giving a negative predictive value of 66.2%.<h4>Conclusions</h4>Use of clinical dysentery as a screening symptom for Shigella infection in children under five presenting with moderate to severe diarrhea has low sensitivity and low positive predictive value respectively. Clinical dysentery as a screening symptom for Shigella contributes to gross under diagnosis and reporting of Shigella infection among under five children in Zambia. Further research is required to better inform practice on more accurate methods or tools to use in support of routine diagnosis, particularly in low middle-income settings where laboratory diagnosis remains a challenge.https://doi.org/10.1371/journal.pone.0279012 |
| spellingShingle | Sam Miti Obvious N Chilyabanyama Caroline C Chisenga Mwelwa Chibuye Samuel Bosomprah Chisenga Mumba Salome Chitondo Seter Siziya Dani Cohen Roma Chilengi Michelo Simuyandi Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia. PLoS ONE |
| title | Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia. |
| title_full | Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia. |
| title_fullStr | Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia. |
| title_full_unstemmed | Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia. |
| title_short | Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia. |
| title_sort | sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in zambia |
| url | https://doi.org/10.1371/journal.pone.0279012 |
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